Alcohol
Volume 32, Issue 1 , Pages 19-24 , January 2004

Analysis of tumor necrosis factor-α, transforming growth factor-β1, interleukin-10, and interferon-γ polymorphisms in patients with alcoholic chronic pancreatitis

  • Alexander Schneider

      Affiliations

    • Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
  • ,
  • M.Michael Barmada

      Affiliations

    • Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15213, USA
  • ,
  • Adam Slivka

      Affiliations

    • Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
  • ,
  • John A. Martin

      Affiliations

    • Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
  • ,
  • David C. Whitcomb

      Affiliations

    • Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    • Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15213, USA
    • Department of Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    • VA Pittsburgh Healthcare System, University of Pittsburgh, Pittsburgh, PA 15213, USA
    • Center for Genomic Sciences, University of Pittsburgh, Pittsburgh, PA 15213, USA
    • Corresponding Author InformationCorresponding author. University of Pittsburgh, 571 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15213, USA. Tel.: +1-412-648-9604; fax: +1-412-383-7236.

Received 26 February 2003 ,Revised 21 August 2003 ,Accepted 30 September 2003.

References 

  1. Abdulrazeg EM, Alfirevic A, Gilmore IT, Sutton R, Greenhalf W, Neoptolemos J. TNF-alpha promoter region gene polymorphisms in patients with alcohol-induced chronic pancreatitis. Gastroenterology. 2001;120(Suppl 1):A32; Abstract
  2. Ammann RW. A clinically based classification system for alcoholic chronic pancreatitis: summary of an international workshop on chronic pancreatitis. Pancreas. 1997;14:215–221
  3. Apte MV, Haber PS, Applegate TL, Norton ID, McCaughan GW, Korsten MA, et al. Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture. Gut. 1998;43:128–133
  4. Apte MV, Phillips PA, Fahmy RG, Darby SJ, Rodgers SC, McCaughan GW, et al. Does alcohol directly stimulate pancreatic fibrogenesis? Studies with rat pancreatic stellate cells. Gastroenterology. 2000;118:780–794
  5. Awad MR, El-Gamel A, Hasleton P, Turner DM, Sinnott PJ, Hutchinson IV. Genotypic variation in the transforming growth factor-beta1 gene: association with transforming growth factor-beta1 production, fibrotic lung disease, and graft fibrosis after lung transplantation. Transplantation. 1998;66:1014–1020
  6. Bachem MG, Schneider E, Gross H, Weidenbach H, Schmid RM, Menke A, et al. Identification, culture, and characterization of pancreatic stellate cells in rats and humans. Gastroenterology. 1998;115:421–432
  7. Bradley KA, Boyd-Wickizer J, Powell SH, Burman ML. Alcohol screening questionnaires in women: a critical review. JAMA. 1998;280:166–171
  8. Chan AW, Pristach EA, Welte JW, Russell M. Use of the TWEAK test in screening for alcoholism/heavy drinking in three populations. Alcohol Clin Exp Res. 1993;17:1188–1192
  9. Chen JM, Montier T, Ferec C. Molecular pathology and evolutionary and physiological implications of pancreatitis-associated cationic trypsinogen mutations. Hum Genet. 2001;109:245–252
  10. D'Alfonso S, Richiardi PM. A polymorphic variation in a putative regulation box of the TNFA promoter region. Immunogenetics. 1994;39:150–154
  11. de Beaux AC, Goldie AS, Ross JA, Carter DC, Fearon KC. Serum concentrations of inflammatory mediators related to organ failure in patients with acute pancreatitis. Br J Surg. 1996;83:349–353
  12. Demols AL, Van Laethem JL, Quertinmont E, Degraef C, Delhaye M, Geerts A, et al. Endogenous interleukin-10 modulates fibrosis and regeneration in experimental chronic pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2002;282:G1105–G1112
  13. Drinking in the United States: Main Findings from the 1992 National Longitudinal Alcohol Epidemiologic Survey (NLAES) . First Edition. U.S. Alcohol Epidemiologic Data Reference Manual. Volume 6. Bethesda, MD: National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism; November 1998; (NIH Publication No. 99-3519.)
  14. Etemad B, Whitcomb DC. Chronic pancreatitis: diagnosis, classification, and new genetic developments. Gastroenterology. 2001;120:682–707
  15. Fong CL, Siddiqui AH, Mark DF. Identification and characterization of a novel repressor site in the human tumor necrosis factor alpha gene. Nucleic Acids Res. 1994;22:1108–1114
  16. Grainger DJ, Heathcote K, Chiano M, Snieder H, Kemp PR, Metcalfe JC, et al. Genetic control of the circulating concentration of transforming growth factor type β1. Hum Mol Genet. 1999;8:93–97
  17. Hajeer AH, Hutchinson IV. TNF-alpha gene polymorphism: clinical and biological implications. Microsc Res Tech. 2000;50:216–228
  18. Hanck C, Rossol S, Hartmann A, Singer MV. Cytokine gene expression in peripheral blood mononuclear cells reflects a systemic immune response in alcoholic chronic pancreatitis. Int J Pancreatol. 1999;26:137–145
  19. Hoffmann SC, Stanley EM, Cox ED, DiMercurio BS, Koziol DE, Harlan DM, et al. Ethnicity greatly influences cytokine gene polymorphism distribution. Am J Transplant. 2002;2:560–567
  20. Kroeger KM, Carville KS, Abraham LJ. The −308 tumor necrosis factor-α promoter polymorphism effects transcription. Mol Immunol. 1997;34:391–399
  21. Mews P, Phillips P, Fahmy R, Korsten M, Pirola R, Wilson J, et al. Pancreatic stellate cells respond to inflammatory cytokines: potential role in chronic pancreatitis. Gut. 2002;50:535–541
  22. Monaghan KG, Jackson CE, KuKuruga DL, Feldman GL. Mutation analysis of the cystic fibrosis and cationic trypsinogen genes in patients with alcohol-related pancreatitis. Am J Med Genet. 2000;94:120–124
  23. Perrey C, Pravica V, Sinnott PJ, Hutchinson IV. Genotyping for polymorphisms in interferon-gamma, interleukin-10, transforming growth factor-beta1 and tumour necrosis factor-alpha genes: a technical report. Transpl Immunol. 1998;6:193–197
  24. Perrey C, Turner SJ, Pravica V, Howell WM, Hutchinson IV. ARMS-PCR methodologies to determine IL-10, TNF-α, TNF-β and TGF-β1 gene polymorphisms. Transpl Immunol. 1999;7:127–128
  25. Pezzilli R, Billi P, Miniero R, Barakat B. Serum interleukin-10 in human acute pancreatitis. Dig Dis Sci. 1997;42:1469–1472
  26. Pfützer RH, Barmada MM, Brunskill AP, Finch R, Hart PS, Neoptolemos J, et al. SPINK1/PSTI polymorphisms act as disease modifiers in familial and idiopathic chronic pancreatitis. Gastroenterology. 2000;119:615–623
  27. Powell JJ, Fearon KC, Siriwardena AK, Ross JA. Evidence against a role for polymorphisms at tumor necrosis factor, interleukin-1 and interleukin-1 receptor antagonist gene loci in the regulation of disease severity in acute pancreatitis. Surgery. 2001;129:633–640
  28. Pravica V, Perrey C, Stevens A, Lee JH, Hutchinson IV. A single nucleotide polymorphism in the first intron of the human IFN-gamma gene: absolute correlation with a polymorphic CA microsatellite marker of high IFN-γ production. Hum Immunol. 2000;61:863–866
  29. Rongione AJ, Kusske AM, Kwan K, Ashley SW, Reber HA, McFadden DW. Interleukin-10 reduces the severity of acute pancreatitis in rats. Gastroenterology. 1997;112:960–967
  30. Sargen K, Demaine AG, Kingsnorth AN. Cytokine gene polymorphisms in acute pancreatitis. JOP. 2000;1:24–35
  31. Saurer L, Reber P, Schaffner T, Büchler MW, Buri C, Kappeler A, et al. Differential expression of chemokines in normal pancreas and in chronic pancreatitis. Gastroenterology. 2000;118:356–367
  32. Schneider A, Pogue-Geile K, Barmada MM, Myers-Fong E, Thompson BS, Whitcomb DC. Hereditary, familial, and idiopathic chronic pancreatitis are not associated with polymorphisms in the tumor necrosis factor α (TNF-α) promoter region or the TNF receptor 1 (TNFR1) gene. Genet Med. 2003;5:120–125
  33. Schneider A, Suman A, Rossi L, Barmada MM, Beglinger C, Parvin S, et al. SPINK1/PSTI mutations are associated with tropical pancreatitis and type II diabetes mellitus in Bangladesh. Gastroenterology. 2002;123:1026–1030
  34. Sime PJ, O'Reilly KM. Fibrosis of the lung and other tissues: new concepts in pathogenesis and treatment. Clin Immunol. 2001;99:308–319
  35. Sparmann G, Behrend S, Merkord J, Kleine HD, Graser E, Ritter T, et al. Cytokine mRNA levels and lymphocyte infiltration in pancreatic tissue during experimental chronic pancreatitis induced by dibutyltin dichloride. Dig Dis Sci. 2001;46:1647–1656
  36. Teich N, Mössner J, Keim V. Screening for mutations of the cationic trypsinogen gene: are they of relevance in chronic alcoholic pancreatitis?. Gut. 1999;44:413–416
  37. Turner DM, Williams DM, Sankaran D, Lazarus M, Sinnott PJ, Hutchinson IV. An investigation of polymorphism in the interleukin-10 gene promoter. Eur J Immunogenet. 1997;24:1–8
  38. van Laethem JL, Deviere J, Resibois A, Rickaert F, Vertongen P, Ohtani H, et al. Localization of transforming growth factor β1 and its latent binding protein in human chronic pancreatitis. Gastroenterology. 1995;108:1873–1881
  39. Wilson AG, Symons JA, McDowell TL, McDevitt HO, Duff GW. Effects of a polymorphism in the human tumor necrosis factor-α promoter on transcriptional activation. Proc Natl Acad Sci U S A. 1997;94:3195–3199
  40. Witt H, Luck W, Becker M, Böhmig M, Kage A, Truninger K, et al. Mutation in the SPINK1 trypsin inhibitor gene, alcohol abuse, and chronic pancreatitis. JAMA. 2001;285:2716–2717
  41. Witt H, Luck W, Hennies HC, Classen M, Kage A, Lass U, et al. Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis. Nat Genet. 2000;25:213–216
  42. Wu MS, Huang SP, Chang YT, Shun CT, Chang MC, Lin MT, et al. Tumor necrosis factor-α and interleukin-10 promoter polymorphisms in Epstein-Barr virus–associated gastric carcinoma. J Infect Dis. 2002;185:106–109
  43. Xie MJ, Motoo Y, Su SB, Sawabu N. Expression of tumor necrosis factor-α, interleukin-6, and interferon-γ in spontaneous chronic pancreatitis in the WBN/Kob rat. Pancreas. 2001;22:400–408
  44. Yamada Y, Miyauchi A, Goto J, Takagi Y, Okuizumi H, Kanematsu M, et al. Association of a polymorphism of the transforming growth factor-β1 gene with genetic susceptibility to osteoporosis in postmenopausal Japanese women. J Bone Miner Res. 1998;13:1569–1576
  45. Yokota M, Ichihara S, Lin T-L, Nakashima N, Yamada Y. Association of a T29→C polymorphism of the transforming growth factor-β1 gene with genetic susceptibility to myocardial infarction in Japanese. Circulation. 2000;101:2783–2787

PII: S0741-8329(03)00241-6

doi: 10.1016/j.alcohol.2003.09.006

Alcohol
Volume 32, Issue 1 , Pages 19-24 , January 2004