Alcohol
Volume 32, Issue 2 , Pages 91-100 , February 2004

Chronic ethanol ingestion by mice increases expression of CD80 and CD86 by activated macrophages

  • Xiaoyan Zhu

      Affiliations

    • Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    • Present address: Department of Surgery, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
    • ,
  • Ruth A Coleman

      Affiliations

    • Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    • ,
  • Carol Alber

      Affiliations

    • Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    • ,
  • Zuhair K Ballas

      Affiliations

    • Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    • Department of Veterans Affairs Medical Center, Iowa City, IA 52246, USA
    • ,
  • Thomas J Waldschmidt

      Affiliations

    • Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    • ,
  • Nancy B Ray

      Affiliations

    • Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    • ,
  • Arthur M Krieg

      Affiliations

    • Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    • Present address: Coley Pharmaceutical Group, Wellesley, MA 02481, USA.
    • ,
  • Robert T Cook

      Affiliations

    • Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    • Department of Veterans Affairs Medical Center, Iowa City, IA 52246, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1-319-339-7125; fax: +1-319-339-7148.

Received 17 December 2003 ,Revised 27 January 2004 ,Accepted 31 January 2004.

References 

  1. Biermann H, Pietz B, Dreier R, Schmid KW, Sorg C, Sunderkotter C. Murine leukocytes with ring-shaped nuclei include granulocytes, monocytes, and their precursors. J Leukoc Biol. 1999;65:217–231
  2. Bird G. Interleukin-8 in alcoholic liver disease. Acta Gastroenterol Belg. 1994;57:255–259
  3. Bird GLA, Sheron N, Goka AKJ, Alexander GJ, Williams RS. Increased plasma tumor necrosis factor in severe alcoholic hepatitis. Ann Intern Med. 1990;112:917–920
  4. Cook RT. Alcohol abuse, alcoholism, and damage to the immune system—a review. Alcohol Clin Exp Res. 1998;22:1927–1942
  5. Cook RT, Ballas ZK, Waldschmidt TJ, Vandersteen D, LaBrecque DR, Cook BL. Modulation of T-cell adhesion markers, and the CD45R and CD57 antigens in human alcoholics. Alcohol Clin Exp Res. 1995;19:555–563
  6. Cook RT, Garvey MJ, Booth BM, Goeken JA, Stewart B, Noel M. Activated CD-8 cells and HLA DR expression in alcoholics without overt liver disease. J Clin Immunol. 1991;11:246–253
  7. Cook RT, Waldschmidt TJ, Ballas ZK, Cook BL, Booth BM, Stewart BC, et al. Fine T-cell subsets in alcoholics as determined by the expression of L-selectin, leukocyte common antigen, and beta-integrin. Alcohol Clin Exp Res. 1994;18:71–80
  8. Davis HL, Weeranta R, Waldschmidt TJ, Tygrett L, Schorr J, Krieg AM. CpG DNA is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen. J Immunol. 1998;160:870–876
  9. Dawson-Saunders B, Trapp RG. Comparing three or more means. In: Basic and Clinical Biostatistics. Norwalk, CT: Appleton & Lange; 1994;p. 125–142
  10. de Waal Malefyt R, Abrams J, Bennett B, Figdor CG, de Vries JE. Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J Exp Med. 1991;174:1209–1220
  11. Faunce DE, Gregory MS, Kovacs EJ. Acute ethanol exposure prior to thermal injury results in decreased T-cell responses mediated in part by increased production of IL-6. Shock. 1998;10:135–140
  12. Fontanilla CV, Faunce DE, Gregory MS, Messingham KA, Durbin EA, Duffner LA, et al. Anti-interleukin-6 antibody treatment restores cell-mediated immune function in mice with acute ethanol exposure before burn trauma. Alcohol Clin Exp Res. 2000;24:1392–1399
  13. Green SJ, Anaiagolu J, Raney JJ. Oxidative metabolism of murine macrophages. In: Current Protocols in Immunology. New York: John Wiley & Sons; 1994; (3: 14.5.1)
  14. Hill DB, Marsano LS, McClain CJ. Increased plasma interleukin-8 concentrations in alcoholic hepatitis. Hepatology. 1993;18:576–580
  15. Hirano T, Akira S, Taga T, Kishimoto T. Biological and clinical aspects of interleukin 6. Immunol Today. 1990;11:443–449
  16. Kishore R, Hill JR, McMullen MR, Frenkel J, Nagy LE. ERK1/2 and Egr-1 contribute to increased TNF-alpha production in rat Kupffer cells after chronic ethanol feeding. Am J Physiol Gastrointest Liver Physiol. 2002;282:G6–G15
  17. Kishore R, McMullen MR, Nagy LE. Stabilization of tumor necrosis factor α mRNA by chronic ethanol: role of A+U-rich elements and p38 mitogen-activated protein kinase signaling pathway. J Biol Chem. 2001;276:41930–41937
  18. Kolls JK, Xie J, Lei D, Greenberg S, Summer WR, Nelson S. Differential effects of in vivo ethanol on LPS-induced TNF and nitric oxide production in the lung. Am J Physiol. 1995;268(6 Pt 1):L991–L998
  19. Lagasse E, Weissman IL. Flow cytometric identification of murine neutrophils and monocytes. J Immunol Methods. 1996;197:139–150
  20. Le Moine O, Marchant A, De Groote D, Azar C, Goldman M, Deviere J. Role of defective monocyte interleukin-10 release in tumor necrosis factor-alpha overproduction in alcoholics cirrhosis. Hepatology. 1995;22:1436–1439
  21. Lenschow DJ, Walunas TL, Bluestone JA. CD28/B7 system of T cell costimulation. Annu Rev Immunol. 1996;14:233–258
  22. MacGregor RR, Louria DB. Alcohol and infection. Curr Clin Top Infect Dis. 1997;17:291–315
  23. Mattern T, Flad H-D, Brade L, Rietschel ET, Ulmer AJ. Stimulation of human T lymphocytes by LPS is MHC unrestricted, but strongly dependent on B7 interactions. J Immunol. 1998;160:3412–3418
  24. McAdam AJ, Farkash EA, Gewurz BE, Sharpe AH. B7 costimulation is critical for antibody class switching and CD8+ cytotoxic T-lymphocyte generation in the host response to vesicular stomatitis virus. J Virol. 2000;74:203–208
  25. McAdam AJ, Schweitzer AN, Sharpe AH. The role of B7 co-stimulation in activation and differentiation of CD4+ and CD8+ T cells. Immunol Rev. 1998;165:231–247
  26. McClain C, Hill D, Schmidt J, Diehl AM. Cytokines and alcoholic liver disease. Semin Liver Dis. 1993;13:170–182
  27. McClain CJ, Barve S, Barve S, Deaciuc I, Hill DB. Tumor necrosis factor and alcoholic liver disease. Alcohol Clin Exp Res. 1998;22(5 Suppl):248S–252S
  28. McClain CJ, Barve S, Deaciuc I, Kugelmas M, Hill D. Cytokines in alcoholic liver disease. Semin Liver Dis. 1999;19:205–219
  29. McClain CJ, Cohen DA. Increased tumor necrosis factor production by monocytes in alcoholic hepatitis. Hepatology. 1989;9:349–351
  30. Pasare C, Medzhitov R. Toll pathway-dependent blockade of CD4+CD25+ T cell–mediated suppression by dendritic cells. Science. 2003;299:1033–1036
  31. Sokal RR, Rohlf FJ. Paired comparisons. Biometry: the Principles and Practice of Statistics in Biological Research. 2nd ed.. San Francisco: W.H. Freeman; 1981; pp. 354–359
  32. Song C, Lin A, De Jong R, Vandoolaeghe E, Kenis G, Bosmans E, et al. Cytokines in detoxified patients with chronic alcoholism without liver disease: increased monocytic cytokine production. Biol Psychiatry. 1999;45:1212–1216
  33. Song K, Coleman RA, Alber C, Ballas ZK, Waldschmidt TJ, Mortari F, et al. TH1 cytokine response of CD57+ T-cell subsets in healthy controls and patients with alcoholic liver disease. Alcohol. 2001;24:155–167
  34. Song K, Coleman RA, Zhu X, Alber C, Ballas ZK, Waldschmidt TJ, et al. Chronic ethanol consumption by mice results in activated splenic T cells. J Leukoc Biol. 2002;72:1109–1116
  35. Song KJ, Coleman RA, Haugen TH, Waldschmidt TJ, LaBrecque DR, Ballas ZK, et al. Expression of CD40 ligand, CD27 ligand and cytoplasmic cytokines by activated CD4+ T-cells of alcoholics with liver disease. Alcohol Clin Exp Res. 1998;22:20A; (Abstract)
  36. Song KJ, Coleman RA, Zhu X, Alber C, Ballas ZK, Waldschmidt TJ, et al. Activation of splenic T cells in C57Bl/6 mice by chronic ethanol. Alcohol Clin Exp Res. 2001;25:26A; (Abstract)
  37. Szabo G, Mandrekar P, Catalano D. Inhibition of superantigen-induced T cell proliferation and monocyte IL-1 beta, TNF-alpha, and IL-6 production by acute ethanol treatment. J Leukoc Biol. 1995;58:342–350
  38. Szabo G, Mandrekar P, Dolganiuc A, Catalano D, Kodys K. Reduced alloreactive T-cell activation after alcohol intake is due to impaired monocyte accessory cell function and correlates with elevated IL-10, IL-13, and decreased IFNγ levels. Alcohol Clin Exp Res. 2001;25:1766–1772
  39. Szabo G, Mandrekar P, Girouard L, Catalano D. Regulation of human monocyte functions by acute ethanol treatment: decreased tumor necrosis factor-alpha, interleukin-1 beta and elevated interleukin-10, and transforming growth factor-beta production. Alcohol Clin Exp Res. 1996;20:900–907
  40. Szabo G, Verma B, Catalano D. Selective inhibition of antigen-specific T lymphocyte proliferation by acute ethanol exposure: the role of impaired monocyte antigen presentation capacity and mediator production. J Leukoc Biol. 1993;54:534–544
  41. Verma BK, Fogarasi M, Szabo G. Down-regulation of tumor necrosis factor alpha activity by acute ethanol treatment in human peripheral blood monocytes. J Clin Immunol. 1993;13:8–22
  42. Waltenbaugh C, Peterson JD. Ethanol impairs the induction of delayed hypersensitivity in C57BL/6 mice. Alcohol. 1997;14:149–153
  43. Zhu X, Coleman RA, Alber C, Ballas ZK, Ray NB, Krieg A, et al. Activation of splenic macrophages in C57Bl/6 mice by chronic alcohol exposure. Alcohol Clin Exp Res. 2002;26:48A; (Abstract)

☆ A paper published as a high-priority communication is one that reviewers have identified as being of high scientific significance and have recommended that the study findings should be communicated to the scientific community as soon as possible.

PII: S0741-8329(04)00011-4

doi: 10.1016/j.alcohol.2004.01.004

Alcohol
Volume 32, Issue 2 , Pages 91-100 , February 2004

Article Tools

* Image Usage & Resolution