Alcohol
Volume 33, Issue 1 , Pages 63-71 , May 2004

Exercise reverses ethanol inhibition of neural stem cell proliferation

Received 6 January 2004 ,Revised 6 April 2004 ,Accepted 20 April 2004.

References 

  1. Abrous DN, Adriani W, Montaron M-F, Aurousseau C, Rougon G, Le Moal M, et al. Nicotine self-administration impairs hippocampal plasticity. J Neurosci. 2002;22:3656–3662
  2. Ardies CM, Morris GS, Erickson CK, Farrar RP. Both acute and chronic exercise enhance in vivo ethanol clearance in rats. J Appl Physiol. 1989;66:555–560
  3. Belknap JK, Crabbe JC, Young ER. Voluntary consumption of ethanol in 15 inbred mouse strains. Psychopharmacology (Berl). 1993;112:503–510
  4. Bison S, Crews F. Alcohol withdrawal increases neuropeptide Y immunoreactivity in rat brain. Alcohol Clin Exp Res. 2003;27:1173–1183
  5. Bowden SC, Crews FT, Bates ME, Fals-Stewart W, Ambrose ML. Neurotoxicity and neurocognitive impairments with alcohol and drug-use disorders: potential roles in addiction and recovery. Alcohol Clin Exp Res. 2001;25:317–321
  6. Cameron HA, McKay RD. Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus. J Comp Neurol. 2001;435:406–417
  7. Cameron HA, Tanapat P, Gould E. Adrenal steroids and N-methyl-d-aspartate receptor activation regulate neurogenesis in the dentate gyrus of adult rats through a common pathway. Neuroscience. 1998;82:349–354
  8. Canzanelli A, Guild R, Rapport D. The use of ethyl alcohol as a fuel in muscular exercise. Am J Physiol. 1934;110:416–421
  9. Carpenter TM, Lee RC, Burdett M. The effect of muscular exercise on the disappearance of ethyl alcohol in man. Am J Physiol. 1933;105:117
  10. Carro E, Nuñez A, Busiguina S, Torres-Aleman I. Circulating insulin-like growth factor I mediates effects of exercise on the brain. J Neurosci. 2000;20:2926–2933
  11. Carro E, Trejo JL, Busiguina S, Torres-Aleman I. Circulating insulin-like growth factor I mediates the protective effects of physical exercise against brain insults of different etiology and anatomy. J Neurosci. 2001;21:5678–5684
  12. Climent E, Pascual M, Renau-Piqueras J, Guerri C. Ethanol exposure enhances cell death in the developing cerebral cortex: role of brain-derived neurotrophic factor and its signaling pathways. J Neurosci Res. 2002;68:213–225
  13. Cotman CW, Berchtold NC. Exercise: a behavioral intervention to enhance brain health and plasticity. Trends Neurosci. 2002;25:295–301
  14. Crews FT. Alcohol & neurodegeneration. CNS Drug Reviews. 1999;5:379–394
  15. Crews FT, Miller MW, Ma W, Nixon K, Zawada WM, Zakhari S. Neural stem cells and alcohol. Alcohol Clin Exp Res. 2003;27:324–335
  16. Dees WL, Dissen GA, Hiney JK, Lara F, Ojeda SR. Alcohol ingestion inhibits the increased secretion of puberty-related hormones in the developing female rhesus monkey. Endocrinology. 2000;141:1325–1331
  17. Eisch AJ, Barrot M, Schad CA, Self DW, Nestler EJ. Opiates inhibit neurogenesis in the adult rat hippocampus. Proc Natl Acad Sci U S A. 2000;97:7579–7584
  18. Estruch R, Nicolás JM, Salamero M, Aragón C, Sacanella E, Fernández-Solà J, et al. Atrophy of the corpus callosum in chronic alcoholism. J Neurol Sci. 1997;146:145–151
  19. Fadda F, Rossetti ZL. Chronic ethanol consumption: from neuroadaptation to neurodegeneration. Prog Neurobiol. 1998;56:385–431
  20. Gensert JM, Goldman JE. Endogenous progenitors remyelinate demyelinated axons in the adult CNS. Neuron. 1997;19:197–203
  21. Gheusi G, Cremer H, McLean H, Chazal G, Vincent J-D, Lledo P-M. Importance of newly generated neurons in the adult olfactory bulb for odor discrimination. Proc Natl Acad Sci U S A. 2000;97:1823–1828
  22. Gould E, McEwen BS, Tanapat P, Galea LA, Fuchs E. Neurogenesis in the dentate gyrus of the adult tree shrew is regulated by psychosocial stress and NMDA receptor activation. J Neurosci. 1997;17:2492–2498
  23. Guillery RW, Herrup K. Quantification without pontification: choosing a method for counting objects in sectioned tissues. J Comp Neurol. 1997;386:2–7
  24. Harding AJ, Wong A, Svoboda M, Kril JJ, Halliday GM. Chronic alcohol consumption does not cause hippocampal neuron loss in humans. Hippocampus. 1997;7:78–87
  25. Institute of Laboratory Animal Resources, Commission on Life Sciences, National Research Council . Guide for the Care and Use of Laboratory Animals. Washington, DC: National Academy Press; 1996;
  26. Kempermann G. Why new neurons? Possible functions for adult hippocampal neurogenesis. J Neurosci. 2002;22:635–638
  27. Kuhn HG, Dickinson-Anson H, Gage FH. Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation. J Neurosci. 1996;16:2027–2033
  28. Kuhn HG, Palmer TD, Fuchs E. Adult neurogenesis: a compensatory mechanism for neuronal damage. Eur Arch Psychiatry Clin Neurosci. 2001;251:152–158
  29. Kuhn HG, Winkler J, Kempermann G, Thal LJ, Gage FH. Epidermal growth factor and fibroblast growth factor-2 have different effects on neural progenitors in the adult rat brain. J Neurosci. 1997;17:5820–5829
  30. Luo J, Miller MW. Growth factor–mediated neural proliferation: target of ethanol toxicity. Brain Res Brain Res Rev. 1998;27:157–167
  31. Malberg JE, Eisch AJ, Nestler EJ, Duman RS. Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. J Neurosci. 2000;20:9104–9110
  32. Mdzinarishvili A, Nixon K, Crews F. Ethanol inhibits neurogenesis in adolescent rats. Society for Neuroscience. 2002;Abstracts 105.9
  33. Miller SS, Goldman ME, Erickson CK, Shorey RL. Induction of physical dependence on and tolerance to ethanol in rats fed a new nutritionally complete and balanced liquid diet. Psychopharmacology (Berl). 1980;68:55–59
  34. Mittleman G, Van Brunt CL, Matthews DB. Schedule-induced ethanol self-administration in DBA/2J and C57BL/6J mice. Alcohol Clin Exp Res. 2003;27:918–925
  35. Nakagawa S, Kim J-E, Lee R, Malberg JE, Chen J, Steffen C, et al. Regulation of neurogenesis in adult mouse hippocampus by cAMP and the cAMP response element-binding protein. J Neurosci. 2002;22:3673–3682
  36. Nixon K, Crews FT. Binge ethanol exposure decreases neurogenesis in adult rat hippocampus. J Neurochem. 2002;83:1087–1093
  37. Petreanu L, Alvarez-Buylla A. Maturation and death of adult-born olfactory bulb granule neurons: role of olfaction. J Neurosci. 2002;22:6106–6113
  38. Pfefferbaum A, Lim KO, Desmond JE, Sullivan EV. Thinning of the corpus callosum in older alcoholic men: a magnetic resonance imaging study. Alcohol Clin Exp Res. 1996;20:752–757
  39. Pham K, Nacher J, Hof PR, McEwen BS. Repeated restraint stress suppresses neurogenesis and induces biphasic PSA-NCAM expression in the adult rat dentate gyrus. Eur J Neurosci. 2003;17:879–886
  40. Popken GJ, Farel PB. Reliability and validity of the physical disector method for estimating neuron number. J Neurobiol. 1996;31:166–174
  41. Popken GJ, Farel PB. Sensory neuron number in neonatal and adult rats estimated by means of stereologic and profile-based methods. J Comp Neurol. 1997;386:8–15
  42. Rodriguez JJ, Montaron MF, Petry KG, Aurousseau C, Marinelli M, Premier S, et al. Complex regulation of the expression of the polysialylated form of the neuronal cell adhesion molecule by glucocorticoids in the rat hippocampus. Eur J Neurosci. 1998;10:2994–3006
  43. Rueda D, Navarro B, Martínez-Serrano A, Guzmán M, Galve-Roperh I. The endocannabinoid anandamide inhibits neuronal progenitor cell differentiation through attenuation of the Rap1/B-Raf/ERK pathway. J Biol Chem. 2002;277:46645–46650
  44. Rupp CI, Kurz M, Kemmler G, Mair D, Hausmann A, Hinterhuber H, et al. Reduced olfactory sensitivity, discrimination, and identification in patients with alcohol dependence. Alcohol Clin Exp Res. 2003;27:432–439
  45. Schuckit M. Alcoholic patients with secondary depression. Am J Psychiatry. 1983;140:711–714
  46. Seaberg RM, van der Kooy D. Adult rodent neurogenic regions: the ventricular subependyma contains neural stem cells, but the dentate gyrus contains restricted progenitors. J Neurosci. 2002;22:1784–1793
  47. Shors TJ, Miesegaes G, Beylin A, Zhao M, Rydel T, Gould E. Neurogenesis in the adult is involved in the formation of trace memories. Nature. 2001;410:372–376
  48. Srivastava V, Hiney JK, Nyberg CL, Dees WL. Effect of ethanol on the synthesis of insulin-like growth factor 1 (IGF-1) and the IGF-1 receptor in late prepubertal female rats: a correlation with serum IGF-1. Alcohol Clin Exp Res. 1995;19:1467–1473
  49. Sterio DC. The unbiased estimation of number and sizes of arbitrary particles using the disector. J Microsc. 1984;134(Pt 2):127–136
  50. Stummer W, Weber K, Tranmer B, Baethmann A, Kempski O. Reduced mortality and brain damage after locomotor activity in gerbil forebrain ischemia. Stroke. 1994;25:1862–1869
  51. Sullivan EV, Fama R, Rosenbloom MJ, Pfefferbaum A. A profile of neuropsychological deficits in alcoholic women. Neuropsychology. 2002;16:74–83
  52. Sullivan EV, Marsh L, Mathalon DH, Lim KO, Pfefferbaum A. Anterior hippocampal volume deficits in nonamnesic, aging chronic alcoholics. Alcohol Clin Exp Res. 1995;19:110–122
  53. Swain RA, Harris AB, Wiener EC, Dutka MV, Morris HD, Theien BE, et al. Prolonged exercise induces angiogenesis and increases cerebral blood volume in primary motor cortex of the rat. Neuroscience. 2003;117:1037–1046
  54. Trejo JL, Carro E, Torres-Alemán I. Circulating insulin-like growth factor I mediates exercise-induced increases in the number of new neurons in the adult hippocampus. J Neurosci. 2001;21:1628–1634
  55. Valentinuzzi VS, Scarbrough K, Takahashi JS, Turek FW. Effects of aging on the circadian rhythm of wheel-running activity in C57BL/6 mice. Am J Physiol. 1997;273(6 Pt 2):R1957–R1964
  56. van Praag H, Kempermann G, Gage FH. Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nat Neurosci. 1999;2:266–270
  57. van Praag H, Schinder AF, Christie BR, Toni N, Palmer TD, Gage FH. Functional neurogenesis in the adult hippocampus. Nature. 2002;415:1030–1034
  58. West MJ, Slomianka L, Gundersen HJ. Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator. Anat Rec. 1991;231:482–497

PII: S0741-8329(04)00081-3

doi: 10.1016/j.alcohol.2004.04.005

Alcohol
Volume 33, Issue 1 , Pages 63-71 , May 2004

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