Alcohol
Volume 34, Issue 2 , Pages 107-114 , October 2004

Nerve growth factor produced by activated human monocytes/macrophages is severely affected by ethanol

  • Maria Cristina Caroleo

      Affiliations

    • Department of Pharmacobiology, Faculty of Pharmacy, University of Calabria, 87036 Cosenza, Italy
    • ,
  • Nicola Costa

      Affiliations

    • Faculty of Pharmacy, University of Magna Graecia, 88100 Catanzaro, Italy
    • ,
  • Paola Tirassa

      Affiliations

    • Institute of Neurobiology and Molecular Medicine, National Research Council, Viale Marx 15/43, 00137 Rome, Italy
    • ,
  • Luigi Aloe

      Affiliations

    • Institute of Neurobiology and Molecular Medicine, National Research Council, Viale Marx 15/43, 00137 Rome, Italy
    • Corresponding Author InformationCorresponding author. Tel.: +0039-06-8292592; fax: +0039-06-86090370.

Received 26 February 2004 ,Revised 21 June 2004 ,Accepted 24 June 2004.

References 

  1. Ajizian SJ, English BK, Meals EA. Specific inhibitors of p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways block inducible nitric oxide synthase and tumor necrosis factor accumulation in murine macrophages stimulated with lipopolysaccharide and interferon-γ. J Infect Dis. 1999;179:939–944
  2. Aloe L, Bracci-Laudiero L, Bonini S, Manni L. The expanding role of nerve growth factor: from neurotrophic activity to immunologic diseases. Allergy. 1997;52:883–894
  3. Aloe L, Bracci-Laudiero L, Tirassa P. The effect of chronic ethanol intake on brain NGF level and on NGF-target tissue of adult mice. Drug Alcohol Depend. 1993;31:159–167
  4. Angelucci F, Cimino M, Balduini W, Piltillo L, Aloe L. Prenatal exposure to ethanol causes differential effects in nerve growth factor and its receptors in the basal forebrain of preweaning and adult rats. J Neural Transplant Plast. 1997;6:63–71
  5. Arbabi S, Garcia I, Bauer GJ, Maier RV. Alcohol (ethanol) inhibits IL-8 and TNF: role of the p38 pathway. J Immunol. 1999;162:7441–7445
  6. Barouch R, Kazimirsky G, Appel E, Brodie C. Nerve growth factor regulates TNF-α production in mouse macrophages via MAP kinase activation. J Leukoc Biol. 2001;69:1019–1026
  7. Bracci Laudiero L, Aloe L, Levi-Montalcini R, Buttinelli C, Schilter D, Gillessen S, et al. Multiple sclerosis patients express increased levels of β-nerve growth factor in cerebrospinal fluid. Neurosci Lett. 1992;146:9–12
  8. Caroleo MC, Costa N, Bracci-Laudiero L, Aloe L. Human monocyte/macrophages activate by exposure to LPS overexpress NGF and NGF receptors. J Neuroimmunol. 2001;113:193–201
  9. Castro A, Lefkowitz DL, Lefkowitz SS. The effect of alcohol on murine macrophage function. Life Sci. 1993;52:1585–1593
  10. Chao MV, Hempstead BL. p75 and Trk: a two receptor system. Trends Neurosci. 1995;19:321–326
  11. Chen C-C, Wang J-K. p38 but not p44/42 mitogen-activated protein kinase is required for nitric oxide synthase induction mediated by lipopolysaccharide in RAW 264.7 macrophages. Mol Pharmacol. 1999;55:481–488
  12. Ehrhard PB, Erb P, Graumann U, Otten U. Expression of nerve growth factor and nerve growth factor receptor tyrosine kinase Trk in activated CD4-positive T-cell clones. Proc Natl Acad Sci U S A. 1993;90:10984–10988
  13. Garaci E, Caroleo MC, Aloe L, Aquaro S, Piacentini M, Costa N, et al. Nerve growth factor is an autocrine factor essential for the survival of macrophages infected with HIV. Proc Natl Acad Sci U S A. 1999;96:14013–14018
  14. Gilhus NE, Matre R. In vitro effect of ethanol on subpopulations of human blood mononuclear cells. Int Arch Allergy Appl Immunol. 1982;68:382–386
  15. Janeway CA, Medzhitov R. Innate immune recognition. Ann Rev Immunol. 2002;20:197–216
  16. Jerrells TR, Sibley D. Effects of ethanol on T-cell mediated immunity to infectious agents. In:  Friedman H,  Klein TW,  Specter S editor. Drugs of Abuse, Immunity and Infections. Boca Raton, FL: CRC Press; 1996;p. 129–141
  17. Kaplan DR, Hempstead BL, Martin-Zanca D, Chao MV, Parada LF. The trk proto-oncogene product: a signal transducing receptor for nerve growth factor. Science. 1991;252:554–558
  18. Labouyrie E, Dubus P, Groppi A, Mahon FX, Ferrer J, Parrens M, et al. Expression of neurotrophins and their receptors in human bone marrow. Am J Pathol. 1999;154:405–415
  19. Lambiase A, Bracci-Laudiero L, Bonini S, Storace G, D'Elios MM, De Carli M, et al. Human CD4+ T cell clones produce and release nerve growth factor and express high-affinity nerve growth factor receptors. J Allergy Clin Immunol. 1997;100:408–414
  20. Laskin DL, Pendino KJ. Macrophages and inflammatory mediators in tissue injury. Ann Rev Pharmacol Toxicol. 1995;35:655–677
  21. Libon C, Forestier F, Cotte-Lafitte J, Labarre C, Quero AM. Effect of acute oral administration of alcohol on superoxide anion production from mouse alveolar macrophages. J Leukoc Biol. 1993;53:93–98
  22. Medzhitov R, Janeway CA. Innate immunity: the virtues of a nonclonal system of recognition. Cell. 1997;91:295–298
  23. Mikszta JA, Waltenbaugh C, Kim BS. Impaired antigen presentation by splenocytes of ethanol-consuming C57BL/6 mice. Alcohol. 1995;12:265–271
  24. Morland B, Morland J. Reduced Fc-receptor function in human monocytes exposed to ethanol in vitro. Alcohol Alcohol. 1984;19:211–217
  25. Nelson S, Bagby GJ, Bainton G, Warren WR. The effects acute and chronic alcoholism on tumor necrosis factor and inflammatory response. J Infect Dis. 1989;160:422–429
  26. Nilsson G, Forsberg-Nilsson K, Xiang Z, Hallbook F, Nilsson K, Metcalfe DD. Human mast cells express functional TrkA and are a source of nerve growth factor. Eur J Immunol. 1997;27:2295–2301
  27. Rose DM, Winston BW, Chan ED, Riches DWH, Gerwins P, Johnson GL, et al. Fcγ receptor cross-linking activates p42, p38 and JNK/SAPK mitogen-activated protein kinases in murine macrophages. Role for p42 MAPK in Fcγ receptor-stimulated TNF-α synthesis. J Immunol. 1997;158:3433–3438
  28. Stoeckel K, Gagnon C, Guroff G, Thoenen H. Purification of nerve growth factor antibodies by affinity chromatography. J Neurochem. 1976;26:1207–1211
  29. Susaki Y, Shimizu S, Katakura K, Watanabe N, Kawamoto K, Matsumoto M, et al. Functional properties of murine macrophages promoted by nerve growth factor. Blood. 1996;88:4630–4637
  30. Szabo G. Consequence of alcohol consumption on host defence. Alcohol Alcohol. 1999;34:830–841
  31. Szabo G, Mandrekar P, Newman L, Catalano D. Regulation of human monocyte function by acute ethanol treatment: decreased TNF-α, IL-1-β and elevated IL-10 and TGF-β production. Alcohol Clin Exp Res. 1996;20:900–907
  32. Szabo G, Verma B, Catalano D. Selective inhibition of antigen specific T lymphocytes proliferation by acute ethanol exposure: the role of impaired monocyte antigen presentation capacity and mediator production. J Leukoc Biol. 1993;54:534–544
  33. Tirassa P, Stenfors C, Lundeberg T, Aloe L. Cholecystokinin-8 regulation of NGF concentrations in adult mouse brain through a mechanism involving CCK(A) and CCK(B) receptors. Br J Pharmacol. 1998;123:1230–1236
  34. Torcia M, Bracci-Laudiero L, Lucibello M, Nencioni L, Labardi D, Rubertelli A, et al. Nerve growth factor is an autocrine survival factor for memory B lymphocytes. Cell. 1996;85:345–356
  35. Vega JA, Garcia-Suarez O, Hannestad J, Perez-Perez M, Germana A. Neurotrophins and the immune system. J Anat. 2003;203:1–19
  36. Weskamp J, Otten U. An enzyme linked immunoassay for nerve growth factor (NGF): a tool for studying regulatory mechanisms involved in NGF production in brain and peripheral tissues. J Neurochem. 1987;48:1779–1786
  37. Yankner BA, Shooter EM. The biology and mechanism of action of nerve growth factor. Ann Rev Biochem. 1982;51:845–868
  38. Zhao X-J, Marrero L, Song K, Oliver P, Chin SY, Simon H, et al. Acute alcohol inhibits TNF-α processing in human monocytes by inhibiting TNF/TNF-α-converting enzyme interactions in the cell membrane. J Immunol. 2003;170:2923–2931

PII: S0741-8329(04)00107-7

doi: 10.1016/j.alcohol.2004.06.005

Alcohol
Volume 34, Issue 2 , Pages 107-114 , October 2004

Article Tools

* Image Usage & Resolution