Alcohol
Volume 33, Issue 3 , Pages 175-181 , July 2004

T-cell activation after chronic ethanol ingestion in mice

  • Robert T. Cook

      Affiliations

    • Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1-319-335-6631; fax: +1-319-335-8453.
    • ,
  • Xiaoyan Zhu

      Affiliations

    • Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    • Present address: Department of Surgery, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
    • ,
  • Ruth A. Coleman

      Affiliations

    • Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    • ,
  • Zuhair K. Ballas

      Affiliations

    • Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    • Department of Veterans Affairs Medical Center, Iowa City, IA 52246, USA
    • ,
  • Thomas J. Waldschmidt

      Affiliations

    • Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    • ,
  • Nancy B. Ray

      Affiliations

    • Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    • ,
  • Douglas R. LaBrecque

      Affiliations

    • Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    • ,
  • Brian L. Cook

      Affiliations

    • Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    • Department of Veterans Affairs Medical Center, Iowa City, IA 52246, USA

Received 9 March 2004 ,Revised 24 June 2004 ,Accepted 29 June 2004.

References 

  1. Coleman, R. A., Alber, C., Hu, L., Ballas, Z. K., Ray, N., & Cook, R. T. (2003). CD40 ligand is required for ethanol-induced TH1 activation of murine splenic T cells. Presented at the 26th annual meeting of the Research Society on Alcoholism, June 21–25, 2003, Ft. Lauderdale, Florida; Abstract #189. (Alcohol Clin Exp Res 27, 37A.)
  2. Cook RT. Alcohol abuse, alcoholism, and damage to the immune system—a review. Alcohol Clin Exp Res. 1998;22:1927–1942
  3. Cook RT, Ballas ZK, Waldschmidt TJ, Vandersteen D, LaBrecque DR, Cook BL. Modulation of T-cell adhesion markers, and the CD45R and CD57 antigens in human alcoholics. Alcohol Clin Exp Res. 1995;19:555–563
  4. Cook RT, Garvey MJ, Booth BM, Goeken JA, Stewart B, Noel M. Activated CD-8 cells and HLA DR expression in alcoholics without overt liver disease. J Clin Immunol. 1991;11:246–253
  5. Cook RT, Waldschmidt TJ, Ballas ZK, Cook BL, Booth BM, Stewart BC, et al. Fine T-cell subsets in alcoholics as determined by the expression of L-selectin, leukocyte common antigen, and beta-integrin. Alcohol Clin Exp Res. 1994;18:71–80
  6. Cook RT, Waldschmidt TJ, Cook BL, LaBrecque DR, McLatchie K. Loss of the CD5+ and CD45RAhi B cell subsets in alcoholics. Clin Exp Immunol. 1996;103:304–310
  7. MacGregor RR, Louria DB. Alcohol and infection. Curr Clin Top Infect Dis. 1997;17:291–315
  8. McClain CJ, Cohen DA. Increased tumor necrosis factor production by monocytes in alcoholic patients. Hepatology. 1989;9:349–351
  9. Meadows GG, Blank SE, Duncan DD. Influence of ethanol consumption on natural killer cell activity in mice. Alcohol Clin Exp Res. 1989;13:476–479
  10. Song K, Coleman RA, Alber C, Ballas ZK, Waldschmidt TJ, Mortari F, et al. TH1 cytokine response of the CD57+ T-cell subsets in healthy controls and patients with alcoholic liver disease. Alcohol. 2001;24:155–167
  11. Song K, Coleman RA, Zhu X, Alber C, Ballas ZK, Waldschmidt TJ, et al. Chronic ethanol consumption by mice results in activated splenic T cells. J Leukoc Biol. 2002;72:1109–1116
  12. Zhu X, Coleman RA, Alber C, Ballas ZK, Waldschmidt TJ, Ray NB, et al. Chronic ethanol ingestion by mice increases expression of CD80 and CD86 by activated macrophages. Alcohol. 2004;32:91–100

PII: S0741-8329(04)00131-4

doi: 10.1016/j.alcohol.2004.06.007

Alcohol
Volume 33, Issue 3 , Pages 175-181 , July 2004

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