Alcohol
Volume 34, Issue 1 , Pages 45-48 , August 2004

Some novel insights into the pathogenesis of alcoholic steatosis

  • M. Raj Lakshman

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +1-202-745-8330; fax: +1-202-462-2006.

Received 30 March 2004 ,Revised 4 August 2004 ,Accepted 5 August 2004.

References 

  1. An J, Muoio DM, Shiota M, Fujimoto Y, Cline GW, Shulman GI, et al. Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance. Nat Med. 2004;10:268–274
  2. Cook GA, Nielsen RC, Hawkins RA, Mehlman MA, Lakshmanan MR, Veech RL. Effect of glucagon on hepatic malonyl coenzyme A concentration and on lipid synthesis. J Biol Chem. 1977;252:4421–4424
  3. Duseja A, Murlidharan R, Bhansali A, Sharma S, Das A, Chawla Y. Assessment of insulin resistance and effect of metformin in nonalcoholic steatohepatitis—a preliminary report. Indian J Gastroenterology. 2004;23:12–15
  4. Fischer M, You M, Matsumoto M, Crabb DW. Peroxisome proliferator-activated receptor α (PPARα) agonist treatment reverses PPARα dysfunction and abnormalities in hepatic lipid metabolism in ethanol-fed mice. J Biol Chem. 2003;278:27997–28004
  5. French SW. Nutrition in the pathogenesis of alcoholic liver disease. Alcohol Alcohol. 1993;28:97–109
  6. Hardie DG, Carling D, Carlson M. The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell?. Annu Rev Biochem. 1998;67:821–855
  7. Joly J-G, Feinman L, Ishii H, Lieber CS. Effect of chronic ethanol feeding on hepatic microsomal glycerophosphate acetyltransferase activity. J Lipid Res. 1973;14:337–343
  8. Lakshman MR, Chirtel SJ, Chambers LC, Campbell BS. Hepatic synthesis of apoproteins of very low density and high density lipoproteins in perfused rat liver: influence of chronic heavy and moderate doses of ethanol. Alcohol Clin Exp Res. 1989;13:554–559
  9. Lakshman MR, Chirtel SJ, Chambers LL. Roles of ω-3 fatty acids and chronic ethanol in the regulation of plasma and liver lipids and plasma apoproteins A1 and E in rats. J Nutr. 1988;118:1299–1303
  10. Lakshmanan MR, Ezekiel M. Effect of chronic ethanol feeding upon the catabolism of protein and lipid moieties of chylomicrons and very low density lipoproteins in vivo and in the perfused heart system. Alcohol Clin Exp Res. 1985;9:327–330
  11. Lakshmanan MR, Ezekiel M, Campbell BS, Muesing RA. Binding, uptake, and metabolism of chylomicron remnants by hepatocytes from control and chronic ethanol-fed rats. Alcohol Clin Exp Res. 1986;10:412–418
  12. Lakshmanan MR, Felver ME, Veech RL. Alcohol and very low density lipoprotein synthesis and secretion by isolated hepatocytes. Alcohol Clin Exp Res. 1980;4:361–365
  13. Lakshmanan MR, Muesing RA, Cook GA, Veech RL. Regulation of lipogenesis in isolated hepatocytes by triglyceride-rich lipoproteins. J Biol Chem. 1977;252:6581–6584
  14. Lakshmanan MR, Muesing RA, LaRosa JC. Regulation of cholesterol biosynthesis and 3-hydroxy 3-methylglutaryl coenzyme A reductase activity by chylomicron remnants in isolated hepatocytes and perfused liver. J Biol Chem. 1981;256:3037–3043
  15. Lamb RG, Wood CE, Fallon HJ. The effect of acute and chronic ethanol intake on hepatic glycerolipid biosynthesis in the hamster. J Clin Invest. 1979;63:14–20
  16. Li Z, Yang S, Lin H, Huang J, Watkins PA, Moser AB, et al. Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease. Hepatology. 2003;37:343–350
  17. Lieber CS, DeCarli LM, Mak KM, Kim C-I, Leo MA. Attenuation of alcohol-induced hepatic fibrosis by polyunsaturated lecithin. Hepatology. 1990;12:1390–1398
  18. Lieber CS, Robins SJ, Li J, DeCarli LM, Mak KM, Fasulo JM, et al. Phosphatidylcholine protects against fibrosis and cirrhosis in the baboon. Gastroenterology. 1994;106:152–159
  19. Lieber CS, Spritz N, DeCarli LM. Role of dietary, adipose, and endogenously synthesized fatty acids in the pathogenesis of the alcoholic fatty liver. J Clin Invest. 1966;45:51–62
  20. Lieber CS, Weiss DG, Groszmann R, Paronetto F, Schenker S, for the Veterans Affairs Cooperative Study 391 Group . II. Veterans Affairs Cooperative Study of polyenylphosphatidylcholine in alcoholic liver disease. Alcohol Clin Exp Res. 2003;27:1765–1772
  21. Marmillot P, Rao MN, Liu Q-H, Chirtel SJ, Lakshman MR. Effect of dietary ω3-fatty acids and chronic ethanol consumption on reverse cholesterol transport in rats. Metabolism. 2000;49:508–512
  22. McGarry JD, Foster DW. In support of the roles of malonyl-CoA and carnitine acyltransferase I in the regulation of hepatic fatty acid oxidation and ketogenesis. J Biol Chem. 1979;254:8163–8168
  23. Nanji AA, Mendenhall CL, French SW. Beef fat prevents alcoholic liver disease in the rat. Alcohol Clin Exp Res. 1989;13:15–19
  24. Nepokroeff CM, Lakshman MR, Porter JW. Rat liver fatty acid synthetase. In:  Lowenstein JW editors. Methods in Enzymology. Vol. 35, Part B:New York: Academic Press; 1975;p. 34–44
  25. Ontko JA. Effects of ethanol on the metabolism of free fatty acids in isolated liver cells. J Lipid Res. 1973;14:78–86
  26. Xu A, Wang Y, Keshaw H, Xu LY, Lam KSL, Cooper GJS. The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. J Clin Invest. 2003;112:91–100
  27. Yamauchi T, Kamon J, Minokoshi Y, Ito Y, Waki H, Uchida S, et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med. 2002;8:1288–1295
  28. You M, Fischer M, Deeg MA, Crabb DW. Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (SREBP). J Biol Chem. Epub 29 May 2002;277:29342–29347

PII: S0741-8329(04)00151-X

doi: 10.1016/j.alcohol.2004.08.004

Alcohol
Volume 34, Issue 1 , Pages 45-48 , August 2004

Article Tools

* Image Usage & Resolution