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Alcohol
Volume 34, Issue 1
, Pages 9-19
, August 2004
Alcoholic fatty liver: its pathogenesis and mechanism of progression to inflammation and fibrosis
References
- . Involvement of cytochrome P450 2E1 in the (ω–1)-hydroxylation of oleic acid in human and rat liver microsomes. J Lipid Res. 1998;39:1210–1219
- . Polyenylphosphatidylcholine opposes the increase of cytochrome P-4502E1 by ethanol and corrects its iron-induced decrease. Alcohol Clin Exp Res. 1999;23:96–100
- . Dilinoleoylphosphatidylcholine decreases ethanol-induced cytochrome P4502E1. Biochem Biophys Res Commun. 2001;288:1047–1051
- . Evidence that cytochrome P450 2E1 is involved in the (ω-1)-hydroxylation of lauric acid in rat liver microsomes. Biochem Biophys Res Commun. 1994;203:1168–1174
- . Insulin resistance and mitochondrial abnormalities in NASH: a cool look into a burning issue. Gastroenterology. 2001;120:1281–1285(Editorial)
- . Decreased cytochrome oxidase activity in hepatic mitochondria after chronic ethanol consumption and the possible role of decreased cytochrome aa3 content and changes in phospholipids. Biochim Biophys Acta. 1984;797:320–327
- Baraona, E., Matsumura, T., Hernandez, R., Kubota, S., Soong, J., Kawano, S., Kato, S., Inatomi, N., Sato, S., & Lieber, C.S. (1988). Chronic alcohol intake impairs liver oxygenation by decreasing O2 utilization. In K. Kuriyama, A. Takada, & H. Ishii (Eds.), Biomedical and Social Aspects of Alcohol and Alcoholism: Proceedings of the Fourth Congress of the International Society for Biomedical Research on Alcoholism (pp. 387–390). Amsterdam, The Netherlands: Elsevier Science Publishers BV.
- . Decreased tumor necrosis factor-α and interleukin-1α production from intrahepatic mononuclear cells in chronic ethanol consumption and upregulation by endotoxin. Alcohol Clin Exp Res. 1998;22:150–156
- . Liver damage produced by feeding alcohol or sugar and its prevention by choline. Br Med J. 1949;2:1001–1006
- . Activity of polyunsaturated phosphatidylcholine in HbsAg negative chronic active hepatitis and acute alcoholic hepatitis. Z Gastroenterol. 1991;29:21–24
- . Physiological substrates for rat alcohol dehydrogenase classes: aldehydes of lipid peroxidation, ω-hydroxyfatty acids, and retinoids. Arch Biochem Biophys. 1993;307:85–90
- . Utilization of long chain fatty acids by rat liver: studies of the role of fatty acid binding protein. Gastroenterology. 1979;77:241–249
- . DLPC decreases TGFβ1-induced collagen mRNA by inhibiting p38 MAPK in hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol. 2002;283:G1051–G1061
- . The metabolism of acetone in rat. J Biol Chem. 1984;259:231–236
- . The production of 1,2-propanediol in ethanol treated rats. Biochem Biophys Res Commun. 1985;129:426–430
- . Acetaldehyde increases procollagen type I and fibronectin gene transcription in cultured rat fat-storing cells through a protein synthesis-dependent mechanism. Hepatology. 1991;13:758–765
- . Prognostic factors in alcoholic liver disease. Am J Gastroenterol. 1991;86:210–216
- . Pharmacological implications of microsomal enzyme induction. Pharmacol Rev. 1967;19:317–366
- . Effects of long-term vitamin E supplementation in alcoholic cirrhotics. J Am Coll Nutr. 1995;14:192–196
- . S-adenosyl-lmethionine synthetase and phospholipid methyltransferase are inhibited in human cirrhosis. Hepatology. 1988;8:65–68
- . Estrogen-related acetaldehyde elevation in women during alcohol intoxication. Alcohol Clin Exp Res. 1996;20:1192–1195
- . In vitro and in vivo inhibitory effect of ethanol and acetaldehyde on O6-methylguanine transferase. Carcinogenesis. 1988;9:761–766
- . Randomized controlled trial of silymarin treatment in patients with cirrhosis of the liver. J Hepatol. 1989;9:105–113
- . High blood alcohol levels in women. The role of decreased gastric alcohol dehydrogenase activity and first-pass metabolism. N Engl J Med. 1990;322:95–99
- . Oral S-adenosylmethionine in the symptomatic treatment of intrahepatic cholestasis. A double-blind, placebo-controlled study. Gastroenterology. 1990;99:211–215
- . High-level expression of rat class I alcohol dehydrogenase is sufficient for ethanol-induced fat accumulation in transduced HeLa cells. Hepatology. 1999;29:1164–1170
- . Characteristics of acetaldehyde oxidation in rat liver mitochondria. J Biol Chem. 1976;251:4908–4913
- . Humoral immune response to acetaldehyde adducts in alcoholic patients. Res Commun Chem Pathol Pharmacol. 1986;54:3–12
- . The ultrastructure of ethanol induced fatty liver. Fed Proc. 1964;23:579A;(Abstract)
- . The ultrastructure of fatty liver induced by prolonged ethanol ingestion. Am J Pathol. 1966;48:535–555
- . Effect of ethanol on the amount and enzyme activities of hepatic rough and smooth microsomal membranes. Biochim Biophys Acta. 1973;291:411–420
- . Increase of microsomal glucose-6-phosphatase activity after chronic ethanol administration. Metabolism. 1973;22:799–806
- . Ethanol oxidation by liver microsomes: evidence against a separate and distinct enzyme system. Biochem Biophys Res Commun. 1970;39:530–537
- . Non-alcoholic steatohepatitis (NASH): a disease of emerging identity and importance. J Hepatol. 1998;29:495–501
- . Hydroxylation of acetone by ethanol- and acetone-inducible cytochrome P-450 in liver microsomes and reconstituted membranes. FEBS Lett. 1986;196:59–64
- . Male and female intoxication levels for three alcohol doses or do women really get higher than men?. Alcohol Technical Report. 1976;5:544–583
- . Mechanisms of regulation of liver fatty acid–binding protein. Mol Cell Biochem. 1993;123:93–100
- . Ethanol induces transforming growth factor-α expression in hepatocytes, leading to stimulation of collagen synthesis by hepatic stellate cells. Alcohol Clin Exp Res. 2003;27(8 Suppl):58S–63S
- . Isolation and partial characterization of the gene for cytochrome P-450 3a (P-450ALC) and a second closely related gene. Biochem Biophys Res Commun. 1988;150:10–17
- . Induction of cytochrome P-4502E1 by ethanol in rat Kupffer cells. Alcohol Clin Exp Res. 1996;20:207–212
- . Oxidative and reductive metabolism by cytochrome P450 2E1. FASEB J. 1992;6:724–730
- . Identification of ethanol-inducible P-450 isozyme 3a as the acetone and acetol monooxygenase of rabbit microsomes. J Biol Chem. 1985;260:13607–13612
- . Multiple mechanisms in the regulation of ethanol-inducible cytochrome P450IIE1. Bioessays. 1990;12:429–435
- . Formation of 19(S)-, 19(R)-, and 18(R)-hydroxyeicosatetraenoic acids by alcohol-inducible cytochrome P450 2E1. J Biol Chem. 1993;268:12912–12918
- . Ultrastructural alterations in human hepatocytes following ingestion of ethanol with adequate diets. Am J Pathol. 1966;49:593–603
- . Effects of butylated hydroxytoluene on the ultrastructure of rat hepatocytes. Lab Invest. 1967;16:342–348
- . Differential depletion of carotenoids and tocopherol in liver disease. Hepatology. 1993;17:977–986
- . Polyunsaturated lecithin prevents acetaldehyde-mediated hepatic collagen accumulation by stimulating collagenase activity in cultured lipocytes. Hepatology. 1992;15:373–381
- . Medical and Nutritional Complications of Alcoholism: Mechanisms and Management. New York: Plenum Press; 1992;
- . Cytochrome P-4502E1: its physiological and pathological role. Physiol Rev. 1997;77:517–544
- . Microsomal ethanol-oxidizing system (MEOS): the first 30 years (1968–1998)—a review. Alcohol Clin Exp Res. 1999;23:991–1007
- . Alcoholic liver disease: new insights in pathogenesis lead to new treatments. J Hepatol. 2000;32(suppl 1):113–128
- . Alcoholic liver injury: pathogenesis and therapy in 2001. Pathol Biol (Paris). 2001;49:738–752
- . Impaired oxygen utilization: a new mechanism for the hepatotoxicity of ethanol in sub-human primates. J Clin Invest. 1989;83:1682–1690
- . S-adenosyl-l-methionine attenuates alcohol-induced liver injury in the baboon. Hepatology. 1990;11:165–172
- . Ethanol oxidation by hepatic microsomes: adaptive increase after ethanol feeding. Science. 1968;162:917–918
- . Quantitative relationship between amount of dietary fat and severity of the alcoholic fatty liver. Am J Clin Nutr. 1970;23:474–478
- . An experimental model of alcohol feeding and liver injury in the baboon. J Med Primatol. 1974;3:153–163
- . Oxidation of ethanol by hepatic microsomes of acatalasemic mice. Biochem Biophys Res Commun. 1974;60:1187–1192
- . Effects of ethanol on fatty acid metabolism in liver slices. Biochem Biophys Res Commun. 1959;1:302–306
- . Effects of prolonged ethanol intake: production of fatty liver despite adequate diets. J Clin Invest. 1965;44:1009–1021
- . Fatty liver, hyperlipemia and hyperuricemia produced by prolonged alcohol consumption, despite adequate dietary intake. Trans Assoc Am Physicians. 1963;76:289–300
- . Difference in hepatic metabolism of long- and medium-chain fatty acids: the role of fatty acid chain length in the production of the alcoholic fatty liver. J Clin Invest. 1967;46:1451–1460
- . Polyenylphosphatidylcholine decreases alcohol-induced oxidative stress in the baboon. Alcohol Clin Exp Res. 1997;21:375–379
- . Increasing circulating level of dilinoleoylphosphatidylcholine is associated with protection against alcohol induced oxidative stress and liver fibrosis in man. Hepatology. 2000;32:386A;(Abstract)
- . Silymarin retards the progression of alcohol-induced hepatic fibrosis in baboons. J Clin Gastroenterol. 2003;37:336–339
- . Hepatic phosphatidylethanolamine methytransferase activity is decreased by ethanol and increased by phosphatidylcholine. Alcohol Clin Exp Res. 1994;18:592–595
- . Phosphatidylcholine protects against fibrosis and cirrhosis in the baboon. Gastroenterology. 1994;106:152–159
- . The effect of ethanol on fatty acid metabolism: stimulation of hepatic fatty acid synthesis in vitro. J Clin Invest. 1961;40:394–399
- . I. Veterans Affairs Cooperative Study of polyenylphosphatidylcholine in alcoholic liver disease: effects on drinking behavior by nurse/physician teams. Alcohol Clin Exp Res. 2003;27:1757–1764
- . II. Veterans Affairs Cooperative Study of polyenylphosphatidylcholine in alcoholic liver disease. Alcohol Clin Exp Res. 2003;27:1765–1772
- . Gender differences in medium-chain dicarboxylic aciduria in alcoholic men and women. Am J Med. 1999;106:70–75
- . Alcohol consumption enhances fatty acid ω-oxidation, with a greater increase in male than in female rats. Hepatology. 1993;18:1247–1253
- . Collagen synthesis by liver stellate cells is released from its normal feedback regulation by acetaldehyde-induced modification of the carboxyl-terminal propeptide of procollagen. Alcohol Clin Exp Res. 1997;21:1204–1211
- . Polyenylphosphatidylcholine attenuates non-alcoholic hepatic fibrosis and accelerates its regression. J Hepatol. 1996;24:604–613
- . Alcoholic liver injury in baboons: transformation of lipocytes to transitional cells. Gastroenterology. 1984;87:188–200
- . Lipocytes and transitional cells in alcoholic liver disease: a morphometric study. Hepatology. 1988;8:1027–1033
- . S-Adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial. J Hepatology. 1999;30:1081–1089
- . On the significance of the hypertrophy of the smooth endoplasmic reticulum in liver cells after administration of drugs. Biochem Pharmacol. 1967;16:125–131
- . More rapid elimination of alcohol in women as compared to their male siblings. Alcohol Clin Exp Res. 1989;13:752–754
- . The direct oxidation of ethanol by a catalase- and alcohol dehydrogenase–free reconstituted system containing cytochrome P-4501. Arch Biochem Biophys. 1978;187:464–475
- . Acetaldehyde selectively stimulates collagen production in cultured rat liver fat-storing cells but not in hepatocytes. Hepatology. 1990;12(3 Pt 1):511–518
- . Polyenylphosphatidylcholine attenuates alcohol-induced fatty liver and hyperlipemia in rats. J Nutr. 1997;127:1800–1806
- . The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. DNA Cell Biol. 1993;12:1–51
- . Polyunsaturated phosphatidyl-choline and interferon alpha for treatment of chronic hepatitis B and C: a multi-center, randomized, double-blind, placebo-controlled trial. Hepatogastroenterology. 1998;45:797–804
- . Antibodies against acetaldehyde-modified protein epitopes in human alcoholics. Hepatology. 1987;7:1210–1214
- . Reconstitution of the microsomal ethanol-oxidizing system: qualitative and quantitative changes of cytochrome P-450 after chronic ethanol consumption. J Biol Chem. 1977;252:7124–7131
- . Dilinoleoylphosphatidylcholine selectively modulates lipopolysaccharide-induced Kupffer cell activation. J Lab Clin Med. 1999;134:466–470
- . Effects of silymarin in alcoholic patients with cirrhosis of the liver: results of a controlled, double-blind, randomized and multicenter trial. J Hepatol. 1998;28:615–621
- . Dilinoleoylphosphatidylcholine decreases hepatic stellate cell activation. J Lab Clin Med. 1999;133:342–348
- . Induction of cytochrome P450IIE1 in the obese overfed rat. Mol Pharmacol. 1991;39:275–280
- . Acetone metabolism in humans during diabetic ketoacidosis. Diabetes. 1986;35:668–674
- . Ethanol oxidation in the microsomal fraction of rat liver. Biochem Biophys Res Commun. 1969;36:596–602
- . Respective roles of human cytochrome P-4502E1, 1A2, and 3A4 in the hepatic microsomal ethanol oxidizing system. Alcohol Clin Exp Res. 1998;22:2125–2132
- . Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities. Gastroenterology. 2001;120:1183–1192
- . Acetaldehyde and lactate stimulate collagen synthesis of cultured baboon liver myofibroblasts. Gastroenterology. 1984;87:777–787
- . Gender differences in the response of hepatic fatty acids and cytosolic fatty acid–binding capacity to alcohol consumption in rats. Proc Soc Exp Biol Med. 1991;198:584–590
- . Induction of cytochrome P-4502E1 in the human liver by ethanol is caused by a corresponding increase in encoding messenger RNA. Hepatology. 1993;17:236–245
- . Alcohol metabolism: role of microsomal oxidation in vivo. Science. 1969;166:627–628
- . Microsomal ethanol-oxidizing system (MEOS): purification and properties of a rat liver system free of catalase and alcohol dehydrogenase. Biochem Biophys Res Commun. 1972;49:1187–1193
- . Hepatic microsomal alcohol-oxidizing system in normal and acatalasemic mice: its dissociation from the peroxidatic activity of catalase-H2O2. Mol Pharmacol. 1975;11:841–849
- . Microsomal ethanol oxidizing system (MEOS): current status of its characterization and its role. Alcohol Clin Exp Res. 1977;1:7–15
- . The role of alcohol dehydrogenase in microsomal ethanol oxidation and the adaptive increase in ethanol metabolism due to chronic treatment with ethanol. Alcohol Clin Exp Res. 1977;1:33–38
- . Hepatic microsomal ethanol oxidation. Hydrogen peroxide formation and the role of catalase. Eur J Biochem. 1972;25:420–430
- . The intralobular distribution of ethanol-inducible P450IIE1 in rat and human liver. Hepatology. 1989;10:437–446
- . Human ethanol-inducible P450IIE1: complete gene sequence, promoter characterization, chromosome mapping, and cDNA-directed expression. Biochemistry. 1988;27:9006–9013
- . The rat P450IIE1 gene: complete intron and exon sequence, chromosome mapping, and correlation of developmental expression with specific 5′ cytosine demethylation. J Biol Chem. 1988;263:4956–4962
- . Absence of ethanol metabolism in “acatalatic” hepatic microsomes that oxidize drugs. Biochem Biophys Res Commun. 1973;52:588–594
- . An unidentified constituent of ethanol oxidation in hepatic microsomes. Fed Proc. 1974;33:554A;(Abstract)
- . Effects of oral S-adenosyl-l-methionine on hepatic glutathione in patients with liver disease. Scand J Gastroenterol. 1989;24:407–415
- . Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis. Hepatology. 1998;27:128–133
- . Ethanol increases hepatocyte water volume. Alcohol Clin Exp Res. 1994;18:1230–1236
- . Chronic ethanol consumption alters rat liver plasma membranes and potentiates release of alkaline phosphatase. Gastroenterology. 1985;88:1799–1806
- . Cytochrome P450IIE1: roles in nitrosamine metabolism and mechanisms of regulation. Drug Metab Rev. 1990;22:147–159
- . Discussion. In: Estabrook RW, Gillette RJ, Lieberman KC editor. Microsomes and Drug Oxidations. Baltimore: Williams & Wilkins; 1972;p. 458
PII: S0741-8329(04)00156-9
doi: 10.1016/j.alcohol.2004.07.008
© 2005 Elsevier Inc. All rights reserved.
« Previous
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Alcohol
Volume 34, Issue 1
, Pages 9-19
, August 2004
