Alcohol
Volume 34, Issue 1 , Pages 21-25 , August 2004

Role of different dietary fatty acids in the pathogenesis of experimental alcoholic liver disease

  • Amin A. Nanji

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +1-215 662-7150; fax: +1-215-662-7529.

Received 30 March 2004 ,Revised 11 August 2004 ,Accepted 11 August 2004.

References 

  1. Barnes PJ, Karin M. Nuclear factor-κB—a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med. 1997;336:1066–1071
  2. Bondy SC. Ethanol toxicity and oxidative stress. Toxicol Lett. 1992;63:231–241
  3. Caro AA, Cederbaum AI. Oxidative stress, toxicology, and pharmacology of CYP2E1. Annu Rev Pharmacol Toxicol. 2004;44:27–42
  4. Cederbaum AI. Role of lipid peroxidation and oxidative stress in alcohol toxicity. Free Radic Biol Med. 1989;7:537–539
  5. Cederbaum AI. Alcohol, oxidative stress and cell injury. Free Radic Biol Med. 2001;31:1524–1526
  6. Dinchuk JE, Car BD, Focht RJ, Johnston JJ, Jaffee BD, Covington MB, et al. Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II. Nature. 1995;378:406–409
  7. French SW. Nutrition in the pathogenesis of alcoholic liver disease. Alcohol Alcohol. 1993;28:97–109
  8. French SW, Miyamoto K, Tsukamoto H. Ethanol-induced hepatic fibrosis in the rat: role of the amount of dietary fat. Alcohol Clin Exp Res. 1986;10(6 Suppl):13S–19S
  9. Hla T, Ristimaki A, Appleby S, Barriocanal JG. Cyclooxygenase gene expression in inflammation and angiogenesis. Ann N Y Acad Sci. 1993;696:197–204
  10. Jokelainen K, Reinke LA, Nanji AA. NF-κB activation is associated with free radical generation and endotoxemia and precedes pathological liver injury in experimental alcoholic liver disease. Cytokine. 2001;16:36–39
  11. Kehrer JP. Free radicals as mediators of tissue injury and disease. Crit Rev Toxicol. 1993;23:21–48
  12. Lieber CS. Biochemical and molecular basis of alcohol-induced injury in liver and other tissues. N Engl J Med. 1988;319:1639–1650
  13. Lieber CS. Cytochrome P-4502E1: its physiological and pathological role. Physiol Rev. 1997;77:517–544
  14. Liu H, Jones BE, Bradham C, Czaja MJ. Increased cytochrome P-450 2EI expression sensitizes hepatocytes to c-Junmediated cell death by TNF-α. Am J Physiol Gastrointest Liver Physiol. 2002;282:G257–G266
  15. Morimoto M, Hagbjörk A-L, Nanji AA, Ingelman-Sundberg M, Lindros KO, Fu PC, et al. Role of cytochrome P4502E1 in alcoholic liver disease pathogenesis. Alcohol. 1993;10:459–464
  16. Nanji AA, French SW. Dietary factors and alcoholic cirrhosis. Alcohol Clin Exp Res. 1986;10:271–273
  17. Nanji AA, Griniuviene B, Sadrzadeh SMH, Levitsky S, McCully JD. Effect of type of dietary fat and ethanol on antioxidant enzyme mRNA induction in rat liver. J Lipid Res. 1995;36:736–744
  18. Nanji AA, Jokelainen K, Rahemtulla A, Miao L, Fogt F, Matsumoto H, et al. Activation of nuclear factor kappa B and cytokine imbalance in experimental alcoholic liver disease in the rat. Hepatology. 1999;30:934–943
  19. Nanji AA, Khettry U, Sadrzadeh SMH. Lactobacillus feeding reduces endotoxemia and severity of experimental alcoholic liver (disease). Proc Soc Exp Biol Med. 1994;205:243–247
  20. Nanji AA, Khettry U, Sadrzadeh SMH, Yamanaka T. Severity of liver injury in experimental alcoholic liver disease. Correlation with plasma endotoxin, prostaglandin E2, leukotriene B4 and thromboxane B2. Am J Pathol. 1993;142:367–373
  21. Nanji AA, Khwaja S, Sadrzadeh SMH. Decreased prostacyclin production by liver non-parenchymal cells precedes liver injury in experimental alcoholic liver disease. Life Sci. 1994;54:455–461
  22. Nanji AA, Mendenhall CL, French SW. Beef fat prevents alcoholic liver disease in the rat. Alcohol Clin Exp Res. 1989;13:15–19
  23. Nanji AA, Miao L, Thomas P, Rahemtulla A, Khwaja S, Zhao S, et al. Enhanced cyclooxygenase-2 gene expression in alcoholic liver disease in the rat. Gastroenterology. 1997;112:943–951
  24. Nanji AA, Zhao S, Lamb RG, Dannenberg AJ, Sadrzadeh SMH, Waxman DJ. Changes in cytochromes P-450, 2E1, 2B1, 4A and phospholipases A and C in the intragastric feeding rat model for alcoholic liver disease: relationship to dietary fats and pathological liver injury. Alcohol Clin Exp Res. 1994;18:902–908
  25. Nanji AA, Zhao S, Sadrzadeh SMH, Dannenberg AJ, Tahan SR, Waxman DJ. Markedly enhanced cytochrome P450 2E1 induction and lipid peroxidation is associated with severe liver injury in fish oil-ethanol-fed rats. Alcohol Clin Exp Res. 1994;18:1280–1285
  26. Otto JC, Smith WL. Prostaglandin endoperoxide synthases-1 and 2. J Lipid Mediat Cell Signal. 1995;12:139–156
  27. Polavarapu R, Spitz DR, Sim JE, Follansbee MH, Oberley LW, Rahemtulla A, et al. Increased lipid peroxidation and impaired antioxidant enzyme function is associated with pathological liver injury in experimental alcoholic disease in rats fed diets high in corn oil and fish oil. Hepatology. 1998;27:1317–1323
  28. Sies H. Strategies of antioxidant defense. Eur J Biochem. 1993;215:213–219
  29. Smith WL, DeWitt DL, Garavito RM. Cyclooxygenases: structural, cellular, and molecular biology. Annu Rev Biochem. 2000;69:145–182
  30. Su GL, Rahemtulla A, Thomas P, Klein RD, Wang SC, Nanji AA. CD14 and lipopolysaccharide binding protein expression in a rat model of alcoholic liver disease. Am J Pathol. 1998;152:841–849

PII: S0741-8329(04)00157-0

doi: 10.1016/j.alcohol.2004.08.005

Alcohol
Volume 34, Issue 1 , Pages 21-25 , August 2004

Article Tools