Alcohol
Volume 34, Issue 2 , Pages 165-175 , October 2004

Substitution profiles of N-methyl-d-aspartate antagonists in ethanol-discriminating inbred mice

  • Keith L. Shelton

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +1-804-827-2104; fax: +1-804-828-2117.

Received 10 May 2004 ,Revised 24 July 2004 ,Accepted 30 July 2004.

References 

  1. Ator NA, Griffiths RR. Principles of drug abuse liability assessment in laboratory animals. Drug Alcohol Depend. 2003;70:S55–S72
  2. Balster RL. Behavioral pharmacology of PCP, NMDA and sigma receptors. NIDA Res Monogr. 1989;95:270–274
  3. Balster RL, Grech DM, Bobelis DJ. Drug discrimination analysis of ethanol as an N-methyl-d-aspartate receptor antagonist. Eur J Pharmacol. 1992;222:39–42
  4. Belknap JK, Metten P, Helms ML, O'Toole LA, Angeli-Gade S, Crabbe JC, et al. Quantitative trait loci (QTL) applications to substances of abuse: physical dependence studies with nitrous oxide and ethanol in BXD mice. Behav Genet. 1993;23:213–222
  5. Bienkowski P, Stefanski R, Kostowski W. Competitive NMDA receptor antagonist, CGP 40116, substitutes for the discriminative stimulus effects of ethanol. Eur J Pharmacol. 1996;314:277–280
  6. Bovetto S, Boyer P-A, Skolnick P, Fossom LH. Chronic administration of a glycine partial agonist alters the expression of N-methyl-d-aspartate receptor subunit mRNAs. J Pharmacol Exp Ther. 1997;283:1503–1508
  7. Bowen CA, Gatto GJ, Grant KA. Assessment of the multiple discriminative stimulus effects of ethanol using an ethanol–pentobarbital–water discrimination in rats. Behav Pharmacol. 1997;8:339–352
  8. Boyer PA, Skolnick P, Fossom LH. Chronic administration of imipramine and citalopram alters the expression of NMDA receptor subunit mRNAs in mouse brain. A quantitative in situ hybridization study. J Mol Neurosci. 1998;10:219–233
  9. Browman KE, Rustay NR, Nikolaidis N, Crawshaw L, Crabbe JC. Sensitivity and tolerance to ethanol in mouse lines selected for ethanol-induced hypothermia. Pharmacol Biochem Behav. 2000;67:821–829
  10. Bueno OF, Carlini EA, Finkelfarb E, Suzuki JS. Delta 9-Tetrahydrocannabinol, ethanol, and amphetamine as discriminative stimuli-generalization tests with other drugs. Psychopharmacologia. 1976;46:235–243
  11. Colombo G, Agabio R, Lobina C, Reali R, Fadda F, Gessa GL. Symmetrical generalization between the discriminative stimulus effects of gamma-hydroxybutyric acid and ethanol: occurrence within narrow dose ranges. Physiol Behav. 1995;57:105–111
  12. Colpaert FC. Drug discrimination in neurobiology. Pharmacol Biochem Behav. 1999;64:337–345
  13. Crabbe JC. Genetic contributions to addiction. Annu Rev Psychol. 2002;53:435–462
  14. Crabbe JC, Belknap JK, Mitchell SR, Crawshaw LI. Quantitative trait loci mapping of genes that influence the sensitivity and tolerance to ethanol-induced hypothermia in BXD recombinant inbred mice. J Pharmacol Exp Ther. 1994;269:184–192
  15. Crabbe JC, Phillips TJ, Buck KJ, Cunningham CL, Belknap JK. Identifying genes for alcohol and drug sensitivity: recent progress and future directions. Trends Neurosci. 1999;22:173–179
  16. Crawley JN, Belknap JK, Collins A, Crabbe JC, Frankel W, Henderson N, et al. Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies. Psychopharmacology (Berl). 1997;132:107–124
  17. Crosby MJ, Hanson JE, Fleckenstein AE, Hanson GR. Phencyclidine increases vesicular dopamine uptake. Eur J Pharmacol. 2002;438:75–78
  18. Cull-Candy S, Brickley S, Farrant M. NMDA receptor subunits: diversity, development and disease. Curr Opin Neurobiol. 2001;11:327–335
  19. Cunningham CL, Niehus DR, Malott DH, Prather LK. Genetic differences in the rewarding and activating effects of morphine and ethanol. Psychopharmacology (Berl). 1992;107:385–393
  20. de Waele JP, Gianoulakis C. Characterization of the mu and delta opioid receptors in the brain of the C57BL/6 and DBA/2 mice, selected for their differences in voluntary ethanol consumption. Alcohol Clin Exp Res. 1997;21:754–762
  21. Finn DA, Roberts AJ, Lotrich F, Gallaher EJ. Genetic differences in behavioral sensitivity to a neuroactive steroid. J Pharmacol Exp Ther. 1997;280:820–828
  22. Grant KA. Emerging neurochemical concepts in the actions of ethanol at ligand-gated ion channels. Behav Pharmacol 5(4 and 5). 1994;383–404
  23. Grant KA. Strategies for understanding the pharmacological effects of ethanol with drug discrimination procedures. Pharmacol Biochem Behav. 1999;64:261–267
  24. Grant KA, Azarov A, Bowen CA, Mirkis S, Purdy RH. Ethanol-like discriminative stimulus effects of the neurosteroid 3 alpha-hydroxy-5 alpha-pregnan-20-one in female Macaca fascicularis monkeys. Psychopharmacology (Berl). 1996;124:340–346
  25. Grant KA, Colombo G. Discriminative stimulus effects of ethanol: effect of training dose on the substitution of N-methyl-d-aspartate antagonists. J Pharmacol Exp Ther. 1993;264:1241–1247
  26. Grant KA, Colombo G, Gatto GJ. Characterization of the ethanol-like discriminative stimulus effects of 5-HT receptor agonists as a function of ethanol training dose. Psychopharmacology (Berl). 1997;133:133–141
  27. Grant KA, Knisely JS, Tabakoff B, Barrett JE, Balster RL. Ethanol-like discriminative stimulus effects of non-competitive n-methyl-d-aspartate antagonists. Behav Pharmacol. 1991;2:87–95
  28. Grant KA, Waters CA, Green-Jordan K, Azarov A, Szeliga KT. Characterization of the discriminative stimulus effects of GABAA receptor ligands in Macaca fascicularis monkeys under different ethanol training conditions. Psychopharmacology (Berl). 2000;152:181–188
  29. Green KL, Grant KA. Effects of l-type voltage-sensitive calcium channel modulators on the discriminative stimulus effects of ethanol in rats. Alcohol Clin Exp Res. 1999;23:806–814
  30. Green-Jordan K, Grant KA. Modulation of the ethanol-like discriminative stimulus effects of diazepam and phencyclidine by l-type voltage-gated calcium-channel ligands in rats. Psychopharmacology (Berl). 2000;149:84–92
  31. Harrison YE, Jenkins JA, Rocha BA, Lytle DA, Jung ME, Oglesby MW. Discriminative stimulus effects of diazepam, ketamine and their mixture: ethanol substitution patterns. Behav Pharmacol. 1998;9:31–40
  32. Hiltunen AJ, Jarbe TU. Discrimination of Ro 11-6896, chlordiazepoxide and ethanol in gerbils: generalization and antagonism tests. Psychopharmacology (Berl). 1986;89:284–290
  33. Hitzemann B, Hitzemann R. Chlordiazepoxide-induced expression of c-Fos in the central extended amygdala and other brain regions of the C57BL/6J and DBA/2J inbred mouse strains: relationships to mechanisms of ethanol action. Alcohol Clin Exp Res. 1999;23:1158–1172
  34. Hodge CW, Cox AA. The discriminative stimulus effects of ethanol are mediated by NMDA and GABAA receptors in specific limbic brain regions. Psychopharmacology (Berl). 1998;139:95–107
  35. Holtzman SG. Drug discrimination studies. Drug Alcohol Depend. 1985;14:263–282
  36. Hundt W, Danysz W, Hölter SM, Spanagel R. Ethanol and N-methyl-d-aspartate receptor complex interactions: a detailed drug discrimination study in the rat. Psychopharmacology (Berl). 1998;135:44–51
  37. Institute of Laboratory Animal Resources, Commission on Life Sciences, National Research Council . Guide for the Care and Use of Laboratory Animals. Washington, DC: National Academy Press; 1996;
  38. Jamensky NT, Gianoulakis C. Content of dynorphins and kappa-opioid receptors in distinct brain regions of C57BL/6 and DBA/2 mice. Alcohol Clin Exp Res. 1997;21:1455–1464
  39. Jamensky NT, Gianoulakis C. Comparison of the proopiomelanocortin and proenkephalin opioid peptide systems in brain regions of the alcohol-preferring C57BL/6 and alcohol-avoiding DBA/2 mice. Alcohol. 1999;18:177–187
  40. Janowsky A, Mah C, Johnson RA, Cunningham CL, Phillips TJ, Crabbe JC, et al. Mapping genes that regulate density of dopamine transporters and correlated behaviors in recombinant inbred mice. J Pharmacol Exp Ther. 2001;298:634–643
  41. Magnusson KR. Declines in mRNA expression of different subunits may account for differential effects of aging on agonist and antagonist binding to the NMDA receptor. J Neurosci. 2000;20:1666–1674
  42. Magnusson KR, Cotman CW. Age-related changes in excitatory amino acid receptors in two mouse strains. Neurobiol Aging. 1993;14:197–206
  43. Maurel S, Schreiber R, De Vry J. Role of 5-HT1B, 5-HT2A and 5-HT2C receptors in the generalization of 5-HT receptor agonists to the ethanol cue in the rat. Behav Pharmacol. 1998;9:337–343
  44. Maurice T, Vignon J, Kamenka JM, Chicheportiche R. Differential interaction of phencyclidine-like drugs with the dopamine uptake complex in vivo. J Neurochem. 1991;56:553–559
  45. McClearn GE, Rodgers DA. Differences in alcohol preference among inbred strains of mice. Q J Stud Alcohol. 1959;20:691–695
  46. Metcalf BR, Stahl JM, Allen JD, Woolfolk DR, Soto PL. Discrimination of gamma-hydroxybutyrate and ethanol administered separately and as a mixture in rats. Pharmacol Biochem Behav. 2001;70:31–41
  47. Middaugh LD, Kelley BM, Cuison ER, Groseclose CH. Naltrexone effects on ethanol reward and discrimination in C57BL/6 mice. Alcohol Clin Exp Res. 1999;23:456–464
  48. Middaugh LD, Kelley BM, Groseclose CH, Cuison ER. Delta-opioid and 5-HT3 receptor antagonist effects on ethanol reward and discrimination in C57BL/6 mice. Pharmacol Biochem Behav. 2000;65:145–154
  49. Miner LL, Marley RJ. Chromosomal mapping of the psychomotor stimulant effects of cocaine in BXD recombinant inbred mice. Psychopharmacology (Berl). 1995;122:209–214
  50. Nankai M, Klarica M, Fage D, Carter C. The pharmacology of native N-methyl-d-aspartate receptor subtypes: different receptors control the release of different striatal and spinal transmitters. Prog Neuropsychopharmacol Biol Psychiatry. 1998;22:35–64
  51. Phillips TJ, Huson MG, McKinnon CS. Localization of genes mediating acute and sensitized locomotor responses to cocaine in BXD/Ty recombinant inbred mice. J Neurosci. 1998;18:3023–3034
  52. Risinger FO, Brown MM, Doan AM, Oakes RA. Mouse strain differences in oral operant ethanol reinforcement under continuous access conditions. Alcohol Clin Exp Res. 1998;22:677–684
  53. Risinger FO, Cunningham CL. Genetic differences in ethanol-induced hyperglycemia and conditioned taste aversion. Life Sci. 1992;50:PL113–PL118
  54. Sanger DJ. Substitution by NMDA antagonists and other drugs in rats trained to discriminate ethanol. Behav Pharmacol. 1993;4:523–528
  55. Sanger DJ. The effects of new hypnotic drugs in rats trained to discriminate ethanol. Behav Pharmacol. 1997;8:287–292
  56. Schechter MD, Meehan SM, Gordon TL, McBurney DM. The NMDA receptor antagonist MK-801 produces ethanol-like discrimination in the rat. Alcohol. 1993;10:197–201
  57. Shelton KL, Balster RL. Ethanol drug discrimination in rats: substitution with GABA agonists and NMDA antagonists. Behav Pharmacol. 1994;5(4 and 5):441–451
  58. Shelton KL, Grant KA. Discriminative stimulus effects of ethanol in C57BL/6J and DBA/2J inbred mice. Alcohol Clin Exp Res. 2002;26:747–757
  59. Simler S, Puglisi-Allegra S, Mandel P. γ-Aminobutyric acid in brain areas of isolated aggressive or non-aggressive inbred strains of mice. Pharmacol Biochem Behav. 1982;16:57–61
  60. Snell LD, Yi SJ, Johnson KM. Comparison of the effects of MK-801 and phencyclidine on catecholamine uptake and NMDA-induced norepinephrine release. Eur J Pharmacol. 1988;145:223–226
  61. Stolerman IP, Mariathasan EA, White J-AW, Olufsen KS. Drug mixtures and ethanol as compound internal stimuli. Pharmacol Biochem Behav. 1999;64:221–228
  62. Tallarida RJ, Murray RB. Manual of Pharmacological Calculations with Computer Programs. 2nd ed.. New York: Springer-Verlag; 1986;
  63. Tolliver BK, Carney JM. Comparison of cocaine and GBR 12935: effects on locomotor activity and stereotypy in two inbred mouse strains. Pharmacol Biochem Behav. 1994;48:733–739
  64. Tolliver BK, Carney JM. Sensitization to stereotypy in DBA/2J but not C57BL/6J mice with repeated cocaine. Pharmacol Biochem Behav. 1994;48:169–173
  65. Tolliver BK, Carney JM. Locomotor stimulant effects of cocaine and novel cocaine analogs in DBA/2J and C57BL/6J inbred mice. Pharmacol Biochem Behav. 1995;50:163–169
  66. Winkler A, Spanagel R. Differences in the kappa opioid receptor mRNA content in distinct brain regions of two inbred mice strains. Neuroreport. 1998;9:1459–1464
  67. Winter JC. The stimulus properties of morphine and ethanol. Psychopharmacologia. 1975;44:209–214

PII: S0741-8329(05)00006-6

doi: 10.1016/j.alcohol.2004.07.014

Alcohol
Volume 34, Issue 2 , Pages 165-175 , October 2004