Alcohol
Volume 34, Issue 2 , Pages 101-105 , October 2004

Fyn kinase does not reduce ethanol inhibition of zinc-insensitive NR2A-containing N-methyl-d-aspartate receptors

  • John J. Woodward

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +1-843-792-5225; fax: +1-843-792-7353.

Received 21 September 2004 ,Revised 10 November 2004 ,Accepted 14 November 2004.

References 

  1. Alvestad RM, Grosshans DR, Coultrap SJ, Nakazawa T, Yamamoto T, Browning MD. Tyrosine dephosphorylation and ethanol inhibition of N-methyl-d-aspartate receptor function. J Biol Chem. 2003;278:11020–11025
  2. Anders DL, Blevins T, Sutton G, Swope S, Chandler LJ, Woodward JJ. Fyn tyrosine kinase reduces the ethanol inhibition of recombinant NR1/NR2A but not NR1/NR2B NMDA receptors expressed in HEK 293 cells. J Neurochem. 1999;72:1389–1393
  3. Blevins T, Mirshahi T, Chandler LJ, Woodward JJ. Effects of acute and chronic ethanol exposure on heteromeric N-methyl-d-aspartate receptors expressed in HEK 293 cells. J Neurochem. 1997;69:2345–2354
  4. Chu B, Anantharam V, Treistman SN. Ethanol inhibition of recombinant heteromeric NMDA channels in the presence and absence of modulators. J Neurochem. 1995;65:140–148
  5. Fayyazuddin A, Villarroel A, Le Goff A, Lerma J, Neyton J. Four residues of the extracellular N-terminal domain of the NR2A subunit control high-affinity Zn2+ binding to NMDA receptors. Neuron. 2000;25:683–694
  6. Li H-F, Kendig JJ. Ethanol withdrawal hyper-responsiveness mediated by NMDA receptors in spinal cord motor neurons. Br J Pharmacol. 2003;139:73–80
  7. Masood K, Wu C, Brauneis U, Weight FF. Differential ethanol sensitivity of recombinant N-methyl-d-aspartate receptor subunits. Mol Pharmacol. 1994;45:324–329
  8. Mirshahi T, Anders DL, Ronald KM, Woodward JJ. Intracellular calcium enhances the ethanol sensitivity of NMDA receptors through an interaction with the C0 domain of the NR1 subunit. J Neurochem. 1998;71:1095–1107
  9. Mirshahi T, Woodward JJ. Ethanol sensitivity of heteromeric NMDA receptors: effects of subunit assembly, glycine and NMDAR1 Mg2+-insensitive mutants. Neuropharmacology. 1995;34:347–355
  10. Miyakawa T, Yagi T, Kitazawa H, Yasuda M, Kawai N, Tsuboi K, et al. Fyn-kinase as a determinant of ethanol sensitivity: relation to NMDA-receptor function. Science. 1997;278:698–701
  11. Paoletti P, Ascher P, Neyton J. High-affinity zinc inhibition of NMDA NR1-NR2A receptors. J Neurosci. 1997;17:5711–5725
  12. Ren H, Honse Y, Peoples RW. A site of alcohol action in the fourth membrane-associated domain of the N-methyl-d-aspartate receptor. J Biol Chem. 2003;278:48815–48820
  13. Ronald KM, Mirshahi T, Woodward JJ. Ethanol inhibition of N-methyl-d-aspartate receptors is reduced by site-directed mutagenesis of a transmembrane domain phenylalanine residue. J Biol Chem. 2001;276:44729–44735
  14. Skeberdis VA, Lan J-y, Zheng X, Zukin RS, Bennett MVL. Insulin promotes rapid delivery of N-methyl-d-aspartate receptors to the cell surface by exocytosis. Proc Natl Acad Sci U S A. 2001;98:3561–3566
  15. Wang YT, Salter MW. Regulation of NMDA receptors by tyrosine kinases and phosphatases. Nature. 1994;369:233–235
  16. Woodward JJ. Ethanol and NMDA receptor signaling. Crit Rev Neurobiol. 2000;14:69–89
  17. Woodward JJ, Smothers C. Ethanol inhibition of recombinant NR1/2A receptors: effects of heavy metal chelators and a zinc-insensitive NR2A mutant. Alcohol. 2003;31:71–76
  18. Yaka R, Phamluong K, Ron D. Scaffolding of Fyn kinase to the NMDA receptor determines brain region sensitivity to ethanol. J Neurosci. 2003;23:3623–3632
  19. Yaka R, Thornton C, Vagts AJ, Phamluong K, Bonci A, Ron D. NMDA receptor function is regulated by the inhibitory scaffolding protein, RACK1. Proc Natl Acad Sci U S A. 2002;99:5710–5715
  20. Zheng F, Gingrich MB, Traynelis SF, Conn PJ. Tyrosine kinase potentiates NMDA receptor currents by reducing tonic zinc inhibition. Nat Neurosci. 1998;1:185–191

 ∗A paper published as a high-priority communication is one that reviewers have identified as being of high scientific significance and have recommended that the study findings should be communicated to the scientific community as soon as possible.

PII: S0741-8329(05)00031-5

doi: 10.1016/j.alcohol.2004.11.003

Alcohol
Volume 34, Issue 2 , Pages 101-105 , October 2004

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