Alcohol
Volume 35, Issue 1 , Pages 13-17 , January 2005

Swift increase in alcohol metabolism (SIAM): understanding the phenomenon of hypermetabolism in liver

  • Blair U. Bradford

      Affiliations

    • 357 Rosenau Hall, Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill, NC 27599-7431, USA
    • ,
  • Ivan Rusyn

      Affiliations

    • Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina, Chapel Hill, NC, 27599-7178, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1-919-843-2596; fax: +1-919-843-2596.

Received 25 June 2004 ,Revised 16 November 2004 ,Accepted 4 December 2004.

References 

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  2. Bernstein J, Videla L, Israel Y. Hormonal influences in the development of the hypermetabolic state of the liver produced by chronic administration of ethanol. J Pharmacol Exp Ther. 1975;192:583–591
  3. Bleyman MA, Thurman RG. The swift increase in alcohol metabolism: comparative studies with other alcohols. Curr Alcohol. 1979;7:115–121
  4. Bradford BU, Enomoto N, Ikejima K, Rose ML, Bojes HK, Forman DT, et al. Peroxisomes are involved in the swift increase in alcohol metabolism. J Pharmacol Exp Ther. 1999;288:254–259
  5. Bradford BU, Forman DT, Thurman RG. 4-Methylpyrazole inhibits fatty acyl coenzyme synthetase and diminishes catalase-dependent alcohol metabolism: has the contribution of alcohol dehydrogenase to alcohol metabolism been previously overestimated?. Mol Pharmacol. 1993;43:115–119
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  8. Bradford BU, Wall CA, Ikejema K, Rossingnol DP, Christ WJ, Thurman RG. The endotoxin antagonist B-464 and antibiotics block the swift increase in alcohol metabolism. Hepatology. 1995;22:550;(Abstract)
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  18. Jeschke MG, Barrow RE, Herndon DN. Extended hypermetabolic response of the liver in severely burned pediatric patients. Arch Surg. 2004;139:641–647
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  30. Thurman RG, Paschal D, Abu-Murad C, Pekkanen L, Bradford BU, Bullock K, et al. Swift increase in alcohol metabolism (SIAM) in the mouse: comparison of the effect of short-term ethanol treatment on ethanol elimination in four inbred strains. J Pharmacol Exp Ther. 1982;223:45–49
  31. Thurman RG, Scholz R. Ethanol metabolism in perfused rat liver at low ethanol concentrations: involvement of alcohol dehydrogenase in the adaptive increase in ethanol metabolism due to chronic pretreatment with ethanol. Hoppe Seylers Z Physiol Chem. 1976;357:1443–1446
  32. Thurman RG, Scholz R. Interaction of glycolysis and respiration in perfused rat liver. Changes in oxygen uptake following the addition of ethanol. Eur J Biochem. 1977;75:13–21
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PII: S0741-8329(05)00053-4

doi: 10.1016/j.alcohol.2004.12.001

Alcohol
Volume 35, Issue 1 , Pages 13-17 , January 2005

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