Alcohol
Volume 35, Issue 2 , Pages 119-128 , February 2005

Effects of acute administration of ethanol on cerebral glucose utilization in adult alcohol-preferring and alcohol-nonpreferring rats

  • Wendy N. Strother

      Affiliations

    • Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, IN 46202-4887, USA
    • Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202-4887, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1-317-274-2333; fax: +1-317-274-1365.
  • ,
  • William J. McBride

      Affiliations

    • Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, IN 46202-4887, USA
    • Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202-4887, USA
    • Department of Biochemistry, Indiana University School of Medicine, Indianapolis, IN 46202-4887, USA
  • ,
  • Lawrence Lumeng

      Affiliations

    • Department of Biochemistry, Indiana University School of Medicine, Indianapolis, IN 46202-4887, USA
    • Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202-4887, USA
  • ,
  • Ting-Kai Li

      Affiliations

    • Department of Biochemistry, Indiana University School of Medicine, Indianapolis, IN 46202-4887, USA
    • Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202-4887, USA
    • Present address: NIAAA, 5635 Fishers Lane, MSC 9304, Bethesda, MD 20892-9304, USA.

Received 13 August 2004 ,Revised 27 December 2004 ,Accepted 10 February 2005.

References 

  1. Abe K, Niikura Y, Misawa M. GABAA receptor-mediated inhibition by ethanol of long-term potentiation in the basolateral amygdala-dentate gyrus pathway in vivo. Neuroscience. 2004;125:113–117
  2. Ariwodola OJ, Crowder TL, Grant KA, Daunais JB, Friedman DP, Weiner JL. Ethanol modulation of excitatory and inhibitory synaptic transmission in rat and monkey dentate granule neurons. Alcohol Clin Exp Res. 2003;27:1632–1639
  3. Ariwodola OJ, Weiner JL. Ethanol potentiation of GABAergic synaptic transmission may be self-limiting: role of presynaptic GABAB receptors. J Neurosci. 2004;24:10679–10686
  4. Azmitia EC, Segal M. An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe nuclei in the rat. J Comp Neurol. 1978;179:641–667
  5. Bare DJ, McKinzie JH, McBride WJ. Development of rapid tolerance to ethanol-stimulated serotonin release in the ventral hippocampus. Alcohol Clin Exp Res. 1998;22:1272–1276
  6. Begleiter H, Porjesz B. What is inherited in the predisposition toward alcoholism? A proposed model. Alcohol Clin Exp Res. 1999;23:1125–1135
  7. Carlson J, Armstrong B, Switzer RC, Ellison G. Selective neurotoxic effects of nicotine on axons in fasciculus retroflexus further support evidence that this a weak link in brain across multiple drugs of abuse. Neuropharmacology. 2000;39:2792–2798
  8. Carlson J, Noguchi K, Ellison G. Nicotine produces selective degeneration in the medial habenula and fasciculus retroflexus. Brain Res. 2001;906:127–134
  9. Cicero TJ. A critique of animal analogues of alcoholis. In:  Majchrowicz E,  Noble EP editor. Biochemistry and Pharmacology of Alcohol. vol. 2:New York: Plenum Press; 1979;p. 533–560
  10. Crane AM, Porrino LJ. Adaptation of the quantitative 2-[14C]deoxyglucose method for use in freely moving rats. Brain Res. 1989;499:87–92
  11. Deitrich RA, Dunwiddie TV, Harris RA, Erwin VG. Mechanism of action of ethanol: initial central nervous system actions. Pharmacol Rev. 1989;41:489–537
  12. Ellison G. Stimulant-induced psychosis, the dopamine theory of schizophrenia, and the habenula. Brain Res Res. 1994;19:223–239
  13. Ellison G. Neural degeneration following chronic stimulant abuse reveals a weak link in brain, fasciculus retroflexus, implying the loss of forebrain control circuitry. Eur Neuropsychopharmacol. 2002;12:287–297
  14. Faingold CL, N'Gouemo P, Riaz A. Ethanol and neurotransmitter interactions–from molecular to integrative effects. Prog Neurobiol. 1998;55:509–535
  15. Givens BS, Breese GR. Electrophysiological evidence that ethanol alters function of medial septal area without affecting lateral septal function. J Pharmacol Exp Ther. 1990;253:95–103
  16. Institute of Laboratory Animal Resources, Commission on Life Sciences, National Research Council . Guide for the Care and Use of Laboratory Animals. Washington, DC: National Academy Press; 1996;
  17. Kadekaro M, Vance WH, Terrell ML, Gary H, Eisenberg HM, Sokoloff L. Effects of antidromic stimulation of the ventral root on glucose utilization in the ventral horn of the spinal cord in the rat. Proc Natl Acad Sci USA. 1987;84:5492–5495
  18. Koob GF, Roberts AJ, Schulteis G, Parsons LH, Heyser CJ, Hyytia P, et al. Neurocircuitry targets in ethanol reward and dependence. Alcohol Clin Exp Res. 1998;22:3–9
  19. Kurumaji A, Dewar D, McCulloch J. Metabolic mapping with deoxyglucose autoradiography as an approach for assessing drug action in the central nervous system. In:  London ED editors. Imaging Drug Action in the Brain. Boca Raton: CRC Press; 1993;p. 207–263
  20. Learn JE, Smith DG, McBride WJ, Lumeng L, Li T-K. Local cerebral glucose utilization rates in alcohol-naïve high-alcohol-drinking (HAD) and low-alcohol-drinking (LAD) rats. Alcohol Clin Exp Res. 2001;25:517–523
  21. Learn JE, Smith DG, McBride WJ, Lumeng L, Li T-K. Ethanol effects on local cerebral glucose utilization in high-alcohol-drinking and low-alcohol-drinking rats. Alcohol. 2003;29:1–9
  22. LeMarquand D, Pihl RO, Benkelfat C. Serotonin and alcohol intake, abuse, and dependence: findings of animal studies. Biol Psychiatry. 1994;36:395–421
  23. Lovinger DM, White G, Weight FF. NMDA receptor-mediated synaptic excitation selectively inhibited by ethanol in hippocampal slice from adult rat. J Neurosci. 1990;10:1372–1379
  24. Matthews DB, Morrow AL. Effects of acute and chronic ethanol exposure on spatial cognitive processing and hippocampal function in the rat. Hippocampus. 2000;10:122–130
  25. McBride WJ. Central nucleus of the amygdala and the effects of alcohol and alcohol-drinking behavior in rodents. Pharmacol Biochem Behav. 2002;71:509–515
  26. McBride WJ, Li T-K. Animal models of alcoholism: neurobiology of high alcohol-drinking behavior in rodents. Crit Rev Neurobiol. 1998;12:339–369
  27. McMillen BA. Toward a definition of a valid animal model of alcoholism: multiple animal models for multiple diseases. Alcohol. 1997;14:409–419
  28. Murphy JM, Stewart RB, Bell RL, Badia-Elder NE, Carr LG, McBride WJ, et al. Phenotypic and genotypic characterization on the Indiana University rat lines selectively bred for high and low alcohol preference. Behav Genet. 2002;32:363–388
  29. Paxinos G, Watson C. The rat brain in stereotaxic coordinates. (4th ed).. New York: Academic Press; 1998;
  30. Polich J, Pollock VE, Bloom FE. Meta-analysis of P300 amplitude from males at risk for alcoholism. Psychol Bull. 1994;115:55–73
  31. Porjesz B, Begleiter H. Alcoholism and human electrophysiology. Alcohol Res Health. 2003;27:153–160
  32. Porrino LJ, Whitlow CT, Samson HH. Effects of the self-administration of ethanol and ethanol/sucrose on rates of local cerebral glucose utilization in rats. Brain Res. 1998;791:18–26
  33. Rangaswamy M, Porjesz B, Chorlian DB, Wang K, Jones KA, Kuperman S, et al. Resting EEG in offspring of male alcoholics: beta frequencies. Int J Psychophysiol. 2004;51:239–251
  34. Sanna E, Talani G, Busonero F, Pisu MG, Purdy RH, Serra M, et al. Brain steroidogenesis mediates ethanol modulation of GABAA receptor activity in rat hippocampus. J Neurosci. 2004;24:6521–6530
  35. Schwartz WJ, Smith CB, Davidsen L, Savaki H, Sokoloff L, Mata M, et al. Metabolic mapping of functional activity in the hypothalamo-neurohypophysial system of the rat. Science. 1979;205:723–725
  36. Simson PE, Criswell HE, Breese GR. Ethanol potentiates gamma-aminobutyric acid-mediated inhibition in the inferior colliculus: evidence for local ethanol/gamma-aminobutyric acid interactions. J Pharmacol Exp Ther. 1991;259:1288–1293
  37. Simson PE, Criswell HE, Breese GR. Inhibition of NMDA-evoked electrophysiological activity by ethanol in selected brain regions: evidence for ethanol-sensitive and ethanol-insensitive NMDA-evoked responses. Brain Res. 1993;607:9–16
  38. Smith DG, Learn JE, McBride WJ, Lumeng L, Li T-K, Murphy JM. Alcohol-naïve alcohol-preferring (P) rats exhibit higher local cerebral glucose utilization than alcohol non-preferring (NP) and Wistar rats. Alcohol Clin Exp Res. 2001;25:1309–1316
  39. Smith DG, Learn JE, McBride WJ, Lumeng L, Li T-K, Murphy JM. Long-term effects of alcohol drinking on cerebral glucose utilization in alcohol-preferring rats. Pharmacol Biochem Behav. 2001;69:543–553
  40. Smith DG, Learn JE, McBride WJ, Lumeng L, Li T-K, Murphy JM. Local cerebral glucose utilization after relapse in ethanol drinking in alcohol-preferring (P) rats. Alcohol. 2002;27:115–126
  41. Sokoloff L, Reivich M, Kennedy C, DesRosiers MH, Patlak CS, Pettigrew KD, et al. The 2-[14C]deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in conscious and anesthetized albino rat. J Neurochem. 1977;28:897–916
  42. Tokunaga S, McDaniel JR, Morrow AL, Matthews DB. Effect of acute ethanol administration and acute allopregnanolone administration on spontaneous hippocampal pyramidal cell neural activity. Brain Res. 2003;967:273–280
  43. VanDoren MJ, Matthews DB, Janis GC, Grobin AC, Devaud LL, Morrow AL. Neuroactive steroid 3alpha-hydroxy-5alpha-pregnan-20-one modulates electrophysiological and behavioral actions of ethanol. J Neurosci. 2000;20:1982–1989
  44. Vertes RP, Fortin WJ, Crane AM. Projections of the median raphe nucleus in the rat. J Comp Neurol. 1999;407:555–582
  45. Volkow ND, Hitzemann R, Wolf AP, Logan J, Folwer JS, Christman D, et al. Acute effects of ethanol on regional brain glucose metabolism and transport. Psychiatry Res Neuroimaging. 1990;35:39–48
  46. Wang G-J, Volkow ND, Franceschi D, Fowler JS, Thanos PK, Scherbaum N, et al. Regional brain metabolism during alcohol intoxication. Alcohol Clin Exp Res. 2000;24:822–829
  47. Weiner JL, Gu C, Dunwiddie TV. Differential ethanol sensitivity of subpopulations of GABAA synapses onto rat hippocampal CA1 pyramidal neurons. J Neurophysiol. 1997;77:1306–1312
  48. White AM, Matthews DB, Best PJ. Ethanol, memory, and hippocampal function: a review of recent findings. Hippocampus. 2000;10:88–93
  49. Wik G, Borg S, Sjogren I, Wiesel FA, Blomqvist G, Borg J, et al. PET determination of regional cerebral glucose metabolism in alcohol-dependent men and healthy controls using 11C-glucose. Acta Psychiatr Scand. 1988;78:234–241
  50. Williams-Hemby L, Porrino LJ. Low and moderate doses of ethanol produce distinct patterns of cerebral metabolic changes in rats. Alcohol Clin Exp Res. 1994;18:982–988

PII: S0741-8329(05)00061-3

doi: 10.1016/j.alcohol.2005.03.003

Alcohol
Volume 35, Issue 2 , Pages 119-128 , February 2005