Alcohol
Volume 35, Issue 2 , Pages 103-112 , February 2005

Ethanol-induced alterations in Rab proteins: possible implications for pituitary dysfunction

  • Jian-Ching Ren

      Affiliations

    • The Neuroscience Program, Loyola University Medical Center, Maywood, IL 60153, USA
    • Research Services, Veterans Affairs Hospital, Hines, IL 60141, USA
    • ,
  • Qianlong Zhu

      Affiliations

    • Research Services, Veterans Affairs Hospital, Hines, IL 60141, USA
    • Department of Medicine, Loyola University Medical Center, Maywood, IL 60153, USA
    • The Alcohol Research Program, Loyola University Medical Center, Maywood, IL 60153, USA
    • ,
  • Nancy LaPaglia

      Affiliations

    • Research Services, Veterans Affairs Hospital, Hines, IL 60141, USA
    • Department of Medicine, Loyola University Medical Center, Maywood, IL 60153, USA
    • ,
  • Nicholas V. Emanuele

      Affiliations

    • Research Services, Veterans Affairs Hospital, Hines, IL 60141, USA
    • Department of Medicine, Loyola University Medical Center, Maywood, IL 60153, USA
    • The Alcohol Research Program, Loyola University Medical Center, Maywood, IL 60153, USA
    • Medical Services, Veterans Affairs Hospital, Hines, IL 60141, USA
    • ,
  • Mary Ann Emanuele

      Affiliations

    • Research Services, Veterans Affairs Hospital, Hines, IL 60141, USA
    • Department of Medicine, Loyola University Medical Center, Maywood, IL 60153, USA
    • The Alcohol Research Program, Loyola University Medical Center, Maywood, IL 60153, USA
    • Medical Services, Veterans Affairs Hospital, Hines, IL 60141, USA
    • Department of Cell Biology, Neurobiology and Anatomy, Loyola University Medical Center, Maywood, IL 60153, USA
    • Corresponding Author InformationCorresponding author. Division of Endocrinology and Metabolism, Loyola University Medical Center, 2160 South First Avenue, Bldg. 117, Rm. 11, Maywood, IL 60153, USA. Tel.: +1-708-216-0436; fax: +1-708-216-5936.

Received 6 August 2004 ,Revised 22 November 2004 ,Accepted 6 February 2005.

References 

  1. Alvarez-Dominguez C, Stahl PD. Interferon-gamma selectively induces Rab5a synthesis and processing in mononuclear cells. J Biol Chem. 1998;273:33901–33904
  2. Antony C, Cibert C, Geraud G, Santa Maria A, Maro B, Mayau V, et al. The small GTP-binding protein rab6p is distributed from medial Golgi to the trans-Golgi network as determined by a confocal microscopic approach. J Cell Sci. 1992;103(Pt 3):785–796
  3. Aridor M, Hannan LA. Traffic jams II: an update of diseases of intracellular transport. Traffic. 2002;3:781–790
  4. Baenziger JU, Green ED. Pituitary glycoprotein hormone oligosaccharides: structure, synthesis and function of the asparagine-linked oligosaccharides on lutropin, follitropin and thyrotropin. Biochim Biophys Acta. 1988;947:287–306
  5. Bock JB, Matern HT, Peden AA, Scheller RH. A genomic perspective on membrane compartment organization. Nature. 2001;409:839–841
  6. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72:248–254
  7. Chen W, Feng Y, Chen D, Wandinger-Ness A. Rab11 is required for trans-golgi network-to-plasma membrane transport and a preferential target for GDP dissociation inhibitor. Mol Biol Cell. 1998;9:3241–3257
  8. Cussac D, Leblanc P, L'Heritier A, Bertoglio J, Lang P, Kordon C, et al. Rho proteins are localized with different membrane compartments involved in vesicular trafficking in anterior pituitary cells. Mol Cell Endocrinol. 1996;119:195–206
  9. Darchen F, Goud B. Multiple aspects of Rab protein action in the secretory pathway: focus on Rab3 and Rab6. Biochimie. 2000;82:375–384
  10. Di Fiore PP, De Camilli P. Endocytosis and signaling. An inseparable partnership. Cell. 2001;106:1–4
  11. Emanuele MA, Halloran MM, Tentler JJ, Uddin S, Emanuele NV, Kelley MR. The effects of ethanol on pituitary function. Compr Ther. 1994;20:326–330
  12. Emanuele MA, Tentler J, Emanuele NV, Kelley MR. In vivo effects of acute EtOH on rat alpha and beta luteinizing hormone gene expression. Alcohol. 1991;8:345–348
  13. Emanuele MA, Tentler J, Reda D, Kirsteins L, Emanuele NV, Lawrence AM. In-vivo effect of ethanol on release of LH-releasing hormone and LH in rats. J Endocrinol. 1989;121:37–41
  14. Emanuele MA, Tentler JJ, Halloran MM, Emanuele NV, Wallock L, Kelley MR. The effect of acute in vivo ethanol exposure on follicle stimulating hormone transcription and translation. Alcohol Clin Exp Res. 1992;16:776–780
  15. Emanuele N, Ren J, LaPaglia N, Steiner J, Emanuele MA. EtOH disrupts female mammalian puberty: age and opiate dependence. Endocrine. 2002;18:247–254
  16. Emanuele NV, LaPagli N, Steiner J, Colantoni A, Van Thiel DH, Emanuele MA. Peripubertal paternal EtOH exposure. Endocrine. 2001;14:213–219
  17. Emanuele NV, LaPaglia N, Vogl W, Steiner J, Kirsteins L, Emanuele MA. Impact and reversibility of chronic ethanol feeding on the reproductive axis in the peripubertal male rat. Endocrine. 1999;11:277–284
  18. Eysseric H, Gonthier B, Soubeyran A, Bessard G, Saxod R, Barret L. Characterization of the production of acetaldehyde by astrocytes in culture after ethanol exposure. Alcohol Clin Exp Res. 1997;21:1018–1023
  19. Fischer von Mollard G, Stahl B, Li C, Sudhof TC, Jahn R. Rab proteins in regulated exocytosis. Trends Biochem Sci. 1994;19:164–168
  20. Ghosh P, Liu QH, Lakshman MR. Long-term ethanol exposure impairs glycosylation of both N- and O-glycosylated proteins in rat liver. Metabolism. 1995;44:890–898
  21. Goud B, Zahraoui A, Tavitian A, Saraste J. Small GTP-binding protein associated with Golgi cisternae. Nature. 1990;345:553–556
  22. Guasch R, Renau-Piqueras J, Guerri C. Chronic ethanol consumption induces accumulation of proteins in the liver Golgi apparatus and decreases galactosyltransferase activity. Alcohol Clin Exp Res. 1992;16:942–948
  23. Hackstadt T. Redirection of host vesicle trafficking pathways by intracellular parasites. Traffic. 2000;1:93–99
  24. Hales CM, Griner R, Hobdy-Henderson KC, Dorn MC, Hardy D, Kumar R, et al. Identification and characterization of a family of Rab11-interacting proteins. J Biol Chem. 2001;276:39067–39075
  25. Harris RA, Burnett R, McQuilkin S, McClard A, Simon FR. Effects of ethanol on membrane order: fluorescence studies. Ann N Y Acad Sci. 1987;492:125–135
  26. Institute of Laboratory Animal Resources, Commission on Life Sciences, National Research Council . Guide for the Care and Use of Laboratory Animals. Washington, DC: National Academy Press; 1996;
  27. Kelley MR, Jurgens JK, Tentler J, Emanuele NV, Blutt SE, Emanuele MA. Coupled reverse transcription-polymerase chain reaction (RT-PCR) technique is comparative, quantitative, and rapid: uses in alcohol research involving low abundance mRNA species such as hypothalamic LHRH and GRF. Alcohol. 1993;10:185–189
  28. Knodler LA, Celli J, Finlay BB. Pathogenic trickery: deception of host cell processes. Nat Rev Mol Cell Biol. 2001;2:578–588
  29. Lakshman MR, Rao MN, Marmillot P. Alcohol and molecular regulation of protein glycosylation and function. Alcohol. 1999;19:239–247
  30. Lapierre LA, Kumar R, Hales CM, Navarre J, Bhartur SG, Burnette JO, et al. Myosin vb is associated with plasma membrane recycling systems. Mol Biol Cell. 2001;12:1843–1857
  31. Larkin JM, Oswald B, McNiven MA. Ethanol-induced retention of nascent proteins in rat hepatocytes is accompanied by altered distribution of the small GTP-binding protein rab2. J Clin Invest. 1996;98:2146–2157
  32. Lledo PM, Vernier P, Vincent JD, Mason WT, Zorec R. Inhibition of Rab3B expression attenuates Ca(2+)-dependent exocytosis in rat anterior pituitary cells. Nature. 1993;364:540–544
  33. Luan P, Balch WE, Emr SD, Burd CG. Molecular dissection of guanine nucleotide dissociation inhibitor function in vivo. Rab-independent binding to membranes and role of Rab recycling factors. J Biol Chem. 1999;274:14806–14817
  34. Marmillot P, Rao MN, Lakshman MR. Chronic ethanol exposure in rats affects rabs-dependent hepatic trafficking of apolipoprotein E and transferrin. Alcohol. 2001;25:195–200
  35. Martinez O, Goud B. Rab proteins. Biochim Biophys Acta. 1998;1404:101–112
  36. Martinez O, Schmidt A, Salamero J, Hoflack B, Roa M, Goud B. The small GTP-binding protein rab6 functions in intra-Golgi transport. J Cell Biol. 1994;127:1575–1588
  37. Mayer T, Touchot N, Elazar Z. Transport between cis and medial Golgi cisternae requires the function of the Ras-related protein Rab6. J Biol Chem. 1996;271:16097–16103
  38. Megias L, Guerri C, Fornas E, Azorin I, Bendala E, Sancho-Tello M, et al. Endocytosis and transcytosis in growing astrocytes in primary culture. Possible implications in neural development. Int J Dev Biol. 2000;44:209–221
  39. Meresse S, Steele-Mortimer O, Moreno E, Desjardins M, Finlay B, Gorvel JP. Controlling the maturation of pathogen-containing vacuoles: a matter of life and death. Nat Cell Biol. 1999;1:E183–E188
  40. Novick P, Zerial M. The diversity of Rab proteins in vesicle transport. Curr Opin Cell Biol. 1997;9:496–504
  41. Olkkonen VM, Ikonen E. Genetic defects of intracellular-membrane transport. N Engl J Med. 2000;343:1095–1104
  42. Parton RG, Schrotz P, Bucci C, Gruenberg J. Plasticity of early endosomes. J Cell Sci. 1992;103(Pt 2):335–348
  43. Pind SN, Nuoffer C, McCaffery JM, Plutner H, Davidson HW, Farquhar MG, et al. Rab1 and Ca2+ are required for the fusion of carrier vesicles mediating endoplasmic reticulum to Golgi transport. J Cell Biol. 1994;125:239–252
  44. Plutner H, Cox AD, Pind S, Khosravi-Far R, Bourne JR, Schwaninger R, et al. Rab1b regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments. J Cell Biol. 1991;115:31–43
  45. Renau-Piqueras J, Guerri C, Burgal M, De Paz P, Saez R, Mayordomo F. Prenatal exposure to ethanol alters plasma membrane glycoproteins of astrocytes during development in primary culture as revealed by concanavalin A binding and 5′-nucleotidase activity. Glia. 1992;5:65–74
  46. Saez R, Burgal M, Renau-Piqueras J, Marques A, Guerri C. Evolution of several cytoskeletal proteins of astrocytes in primary culture: effect of prenatal alcohol exposure. Neurochem Res. 1991;16:737–747
  47. Salonen I, Huhtaniemi I. Effects of chronic ethanol diet on pituitary-testicular function of the rat. Biol Reprod. 1990;42:55–62
  48. Saraste J, Lahtinen U, Goud B. Localization of the small GTP-binding protein rab1p to early compartments of the secretory pathway. J Cell Sci. 1995;108(Pt 4):1541–1552
  49. Segev N. Ypt/rab gtpases: regulators of protein trafficking. Sci STKE. 2001;2001:RE11
  50. Slomiany A, Nowak P, Piotrowski E, Slomiany BL. Effect of ethanol on intracellular vesicular transport from Golgi to the apical cell membrane: role of phosphatidylinositol 3-kinase and phospholipase A2 in Golgi transport vesicles association and fusion with the apical membrane. Alcohol Clin Exp Res. 1998;22:167–175
  51. Somsel Rodman J, Wandinger-Ness A. Rab GTPases coordinate endocytosis. J Cell Sci. 2000;113(Pt 2):183–192
  52. Sun SH, Fu YH, Jou TC, Sun GY, Sun AY. Ethanol effects on phospholipids and triacylglycerols of rat brain astrocyte cell line. Alcohol Alcohol. 1987;(Suppl 1):691–695
  53. Takai Y, Sasaki T, Matozaki T. Small GTP-binding proteins. Physiol Rev. 2001;81:153–208
  54. Tisdale EJ, Bourne JR, Khosravi-Far R, Der CJ, Balch WE. GTP-binding mutants of rab1 and rab2 are potent inhibitors of vesicular transport from the endoplasmic reticulum to the Golgi complex. J Cell Biol. 1992;119:749–761
  55. Torok N, Marks D, Hsiao K, Oswald BJ, McNiven MA. Vesicle movement in rat hepatocytes is reduced by ethanol exposure: alterations in microtubule-based motor enzymes. Gastroenterology. 1997;113:1938–1948
  56. Tuma DJ, Sorrell MF. Effects of ethanol on protein trafficking in the liver. Semin Liver Dis. 1988;8:69–80
  57. Ullrich O, Reinsch S, Urbe S, Zerial M, Parton RG. Rab11 regulates recycling through the pericentriolar recycling endosome. J Cell Biol. 1996;135:913–924
  58. Van Thiel DH, Gavaler JS, Cobb CF, Sherins RJ, Lester R. Alcohol-induced testicular atrophy in the adult male rat. Endocrinology. 1979;105:888–895
  59. White J, Johannes L, Mallard F, Girod A, Grill S, Reinsch S, et al. Rab6 coordinates a novel Golgi to ER retrograde transport pathway in live cells. J Cell Biol. 1999;147:743–760
  60. Yoon Y, Torok N, Krueger E, Oswald B, McNiven MA. Ethanol-induced alterations of the microtubule cytoskeleton in hepatocytes. Am J Physiol. 1998;274:G757–G766
  61. Zerial M, McBride H. Rab proteins as membrane organizers. Nat Rev Mol Cell Biol. 2001;2:107–117

PII: S0741-8329(05)00062-5

doi: 10.1016/j.alcohol.2005.03.004

Alcohol
Volume 35, Issue 2 , Pages 103-112 , February 2005

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