Alcohol
Volume 35, Issue 3 , Pages 243-249 , April 2005

Alcohol, iron-associated oxidative stress, and cancer

  • Dennis R. Petersen

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +1-303-315-6159; fax: +1-303-315-0274.

Received 11 February 2005 ,Revised 18 March 2005 ,Accepted 25 March 2005.

References 

  1. Arteel GE. Oxidants and antioxidants in alcohol-induced liver disease. Gastroenterology. 2003;124:778–790
  2. Baeuerle PA. The inducible transcription activator NF-κB: regulation by distinct protein subunits. Biochim Biophys Acta. 1991;1072:63–80
  3. Cabantchik ZI, Glickstein H, Milgram P, Breuer W. A fluorescence assay for assessing chelation of intracellular iron in a membrane model system and in mammalian cells. Anal Biochem. 1996;233:221–227
  4. Chung F-L, Pan J, Choudhury S, Roy R, Hu W, Tang M-s. Formation of trans-4-hydroxy-2-nonenal- and other enal-derived cyclic DNA adducts from ω-3 and ω-6 polyunsaturated fatty acids and their roles in DNA repair and human p53 gene mutation. Mutat Res. 2003;531:25–26
  5. Deugnier Y. Iron and liver cancer. Alcohol. 2003;30:145–150
  6. Deugnier Y, Loréal O. Iron as a carcinogen. In:  Barton JC,  Edwards CQ editor. Hemochromatosis: Genetics, Pathophysiology, Diagnosis and Treatment. Cambridge: Cambridge University Press; 2000;p. 239–249
  7. Fletcher L, Halliday J, Powell L. Interrelationships of alcohol and iron in liver disease with particular reference to the iron-binding proteins, ferritin and transferrin. J Gastroenterol Hepatol. 1999;14:202–214
  8. Fletcher LM, Dixon JL, Purdie DM, Powell LW, Crawford DHG. Excess alcohol greatly increases the prevalence of cirrhosis in hereditary hemochromatosis. Gastroenterology. 2002;122:281–289
  9. Halliwell B, Gutteridge JMC. Free Radicals in Biology and Medicine (3rd ed.). Noida, India: Thomson Press (India) Ltd; 2003;
  10. Hentze MW, Muckenthaler MU, Andrews NC. Balancing acts: molecular control of mammalian iron metabolism. Cell. 2004;117:285–297
  11. Hoek JB, Pastorino JG. Cellular signaling mechanisms in alcohol-induced liver damage. Semin Liver Dis. 2004;24:257–272
  12. Hu W, Feng Z, Eveleigh J, Iyer G, Pan J, Amin S, et al. The major lipid peroxidation product, trans-4-hydroxy-2-nonenal, preferentially forms DNA adducts at codon 249 of human p53 gene, a unique mutational hotspot in hepatocellular carcinoma. Carcinogenesis. 2002;23:1781–1789
  13. Huang X. Iron overload and its association with cancer risk in humans: evidence for iron as a carcinogenic metal. Mutat Res. 2003;533:153–171
  14. Hussain SP, Raja K, Amstad PA, Sawyer M, Trudel LJ, Wogan GN, et al. Increased p53 mutation load in nontumorous human liver of Wilson disease and hemochromatosis: oxyradical overload diseases. Proc Natl Acad Sci U S A. 2000;97:12770–12775
  15. Klaunig JE, Kamendulis LM. The role of oxidative stress in carcinogenesis. Annu Rev Pharmacol Toxicol. 2004;44:239–267
  16. Knecht KT, Bradford BU, Mason RP, Thurman RG. In vivo formation of a free radical metabolite of ethanol. Mol Pharmacol. 1990;38:26–30
  17. Kono H, Rusyn I, Yin M, Gäbele E, Yamashina S, Dikalova A, et al. NADPH oxidase–derived free radicals are key oxidants in alcohol-induced liver disease. J Clin Invest. 2000;106:867–872
  18. Kruszewski M. Labile iron pool: the main determinant of cellular response to oxidative stress. Mutat Res. 2003;531:81–92
  19. Lauret E, Rodríguez M, González S, Linares A, López-Vázquez A, Martínez-Borra J, et al. HFE gene mutations in alcoholic and virus-related cirrhotic patients with hepatocellular carcinoma. Am J Gastroenterol. 2002;97:1016–1021
  20. Le NTV, Richardson DR. The role of iron in cell cycle progression and the proliferation of neoplastic cells. Biochim Biophys Acta. 2002;1063:31–46
  21. McClain CJ, Barve S, Deaciuc I, Kugelmas M, Hill D. Cytokines in alcoholic liver disease. Semin Liver Dis. 1999;19:205–219
  22. Molavi B, Mehta JL. Oxidative stress in cardiovascular disease: molecular basis of its deleterious effects, its detection, and therapeutic considerations. Curr Opin Cardiol. 2004;19:488–493
  23. Pan J, Chung F-L. Formation of cyclic deoxyguanosine adducts from ω-3 and ω-6 polyunsaturated fatty acids under oxidative conditions. Chem Res Toxicol. 2002;15:367–372
  24. Petrat F, Rauen U, de Groot H. Determination of the chelatable iron pool of isolated rat hepatocytes by digital fluorescence microscopy using the fluorescent probe, phen green SK. Hepatology. 1999;29:1171–1179
  25. Selley ML. (E)-4-Hydroxy-2-nonenal may be involved in the pathogenesis of Parkinson's disease. Free Radic Biol Med. 1998;25:169–174
  26. She H, Xiong S, Lin M, Zandi E, Giulivi C, Tsukamoto H. Iron activates NF-κB in Kupffer cells. Am J Physiol Gastrointest Liver Physiol. 2002;283:G719–G726
  27. Soriano ME, Nicolosi L, Bernardi P. Desensitization of the permeability transition pore by cyclosporin A prevents activation of the mitochondrial apoptotic pathway and liver damage by tumor necrosis factor-α. J Biol Chem. 2004;279:36803–36808
  28. Stewart SF, Vidali M, Day CP, Albano E, Jones DEJ. Oxidative stress as a trigger for cellular immune responses in patients with alcoholic liver disease. Hepatology. 2004;39:197–203
  29. Suzuki Y, Saito H, Suzuki M, Hosoki Y, Sakurai S, Fujimoto Y, et al. Up-regulation of transferrin receptor expression in hepatocytes by habitual alcohol drinking is implicated in hepatic iron overload in alcoholic liver disease. Alcohol Clin Exp Res. 2002;26:26S–31S
  30. Tavill AS, Qadri AM. Alcohol and iron. Semin Liver Dis. 2004;24:317–325
  31. Toyokuni S. Iron-induced carcinogenesis: the role of redox regulation. Free Radic Biol Med. 1996;20:553–566
  32. Toyokuni S. Iron and carcinogenesis; from Fenton reaction to target genes. Redox Report. 2002;7:189–197
  33. Tsukamoto H, Horne W, Kamimura S, Niemelä O, Parkkila S, Ylä-Herttuala S, et al. Experimental liver cirrhosis induced by alcohol and iron. J Clin Invest. 1995;96:620–630
  34. Tsukamoto H, Lin M, Ohata M, Giulivi C, French SW, Brittenham G. Iron primes hepatic macrophages for NF-κB activation in alcoholic liver injury. Am J Physiol Gastrointest Liver Physiol. 1999;277:G1240–G1250
  35. Valerio LG, Parks T, Petersen DR. Alcohol mediates increases in hepatic and serum nonheme iron stores in a rat model for alcohol-induced liver injury. Alcohol Clin Exp Res. 1996;20:1352–1361
  36. Wang XW, Hussain SP, Huo T-I, Wu C-G, Forgues M, Hofseth LJ, et al. Molecular pathogenesis of human hepatocellular carcinoma. Toxicology. 2002;181–182, 43–47
  37. Wriggleworth JM, Baum H. The biochemical function of iron. In:  Jacobs A,  Worwood M editor. Iron in Biochemistry and Medicine, II. London: Academic Press; 1980;p. 29–86
  38. Xiong S, She H, Takeuchi H, Han B, Engelhardt JF, Barton CH, et al. Signaling role of intracellular iron in NF-κB activation. J Biol Chem. 2003;278:17646–17654
  39. Yuan J-M, Govindarajan S, Arakawa K, Yu MC. Synergism of alcohol, diabetes, and viral hepatitis on the risk of hepatocellular carcinoma in blacks and whites in the U.S. Cancer. 2004;101:1009–1017
  40. Zhou Z, Wang L, Song Z, Lambert JC, McClain CJ, Kang YJ. A critical involvement of oxidative stress in acute alcohol-induced hepatic TNF-α production. Am J Pathol. 2003;163:1137–1146

PII: S0741-8329(05)00100-X

doi: 10.1016/j.alcohol.2005.03.013

Alcohol
Volume 35, Issue 3 , Pages 243-249 , April 2005

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