Alcohol
Volume 36, Issue 1 , Pages 5-18 , May 2005

Effect of ethanol administration on Mg2+ transport across liver plasma membrane

Received 29 September 2004 ,Revised 12 February 2005 ,Accepted 15 April 2005.

References 

  1. Cefaratti C, Romani A, Scarpa A. Characterization of two Mg2+ transporters in sealed plasma membrane vesicles from rat liver. Am J Physiol. 1998;275:C995–C1008
  2. Cefaratti C, Romani A, Scarpa A. Differential localization and operation of distinct Mg2+ transporters in apical and basolateral sides of rat liver plasma membrane. J Biol Chem. 2000;275:3772–3780
  3. Cefaratti C, Howard M, Scarpa A. Characterization and operation of a Na+/Mg2+ and a novel Ca2+/Mg2+ antiporter in purified rat cardiac sarcolemmal vesicles. Circulation. 2000;102:363A;(Abstract)
  4. Cefaratti C, Fagan TE, Scarpa A. The role of chemical and electrochemical gradients on MG2+ release in hepatocytes. FASEB J. 2003;17:Abstract 583.9
  5. Deitrich RA, Dunwiddie TV, Harris RA, Erwin VG. Mechanism of action of ethanol: initial central nervous system actions. Pharmacol Rev. 1989;41:489–537
  6. Fagan T, Scarpa A. Hormone-stimulated Mg2+ accumulation into rat hepatocytes: a pathway for rapid Mg2+ and Ca2+ redistribution. Arch Biochem Biophys. 2002;401:277–282
  7. Flatman PW. Mechanisms of magnesium transport. Annu Rev Physiol. 1991;53:259–271
  8. Flink EB. Magnesium deficiency in alcoholism. Alcohol Clin Exp Res. 1986;10:590–594
  9. Gunther T, Vormann J. Activation of Na+/Mg2+ antiport in thymocytes by cAMP. FEBS Lett. 1992;297:132–134
  10. Gunther T. Mechanisms and regulation of Mg2+ efflux and Mg2+ influx. Miner Electrol Metab. 1993;19:259–265
  11. Gunther T. Putative mechanism of Mg2+/Mg2+ exchange and Na+/Mg2+ antiport. Magnes Bull. 1996;18:2–6
  12. Handy RD, Gow IF, Ellis D, Flatman PW. Na-dependent regulation of intracellular free magnesium concentration in isolated rat ventricular myocytes. J Mol Cell Cardiol. 1996;28:1641–1651
  13. Hoek JB, Thomas AP, Rooney TA, Higashi K, Rubin E. Ethanol and signal transduction in the liver. FASEB J. 1992;6:2386–2396
  14. Hubbard AL, Barr VA, Scott LJ. Hepatocyte surface polarity. In:  Arias IM,  Boyer JL,  Fausto N,  Jakoby WB,  Schacter D,  Shafritz DA editor. The Liver: Biology and Pathobiology. 3rd ed.. New York: Raven Press; 1994;p. 189–213
  15. Institute of Laboratory Animal Resources, Commission on Life Sciences, Natural Research Council (1996) Guide for the Care and Use of Laboratory Animals. Washington, DC: National Academy Press.
  16. Korpi ER, Makela R, Uusi-Oukari M. Ethanol: novel actions on nerve cell physiology explain impaired functions. News Physiol Sci. 1998;13:164–170
  17. Lieber CS. Hepatic metabolic and toxic effects of ethanol: a 1991 update. Alcohol Clin Exp Res. 1991;15:573–592
  18. Lieber CS. Alcoholic liver injury: pathogenesis and therapy in 2001. Pathol Biol. 2001;49:738–752
  19. Lieber CS, De Carli LM. Alcoholic liver injury: experimental models in rats and baboons. Adv Exp Med Biol. 1975;59:379–393
  20. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the folin phenol reagent. J Biol Chem. 1951;193:265–275
  21. Mallet RT, Sun J, Fan WL, Kang YH, Bunger R. Magnesium activated adenosine formation in intact perfused heart: predominance of ecto 5′-nucleotidase during hyper-magnesemia. Biochim Biophys Acta. 1996;1290:165–176
  22. Nadler MJ, Hermosura MC, Inabe K, Perraud AL, Zhu Q, Stokes J, et al. LTRPC7 is a Mg.ATP-regulated divalent cation channel required for cell viability. Nature. 2001;411:590–595
  23. Quamme GA, Rabkin SW. Cytosolic free magnesium in cardiac myocytes: identification of a Mg2+ influx pathway. Biochem Biophys Res Commun. 1990;167:1406–1412
  24. Quamme GA, Dai L-S. Presence of a novel influx pathway for Mg2+ in MDCK cells. Am J Physiol. 1990;259:C521–C525
  25. Rayssiguier Y, Chevalier F, Bonnet M, Kopp J, Durlach J. Influence of magnesium deficiency on liver collagen after carbon tetrachloride or ethanol administration to rats. J Nutr. 1985;115:1656–1662
  26. Romani A, Scarpa A. Regulation of cell magnesium. Arch Biochem Biophys. 1992;298:1–12
  27. Romani A, Marfella C, Scarpa A. Regulation of Mg2+ uptake in isolated rat myocytes and hepatocytes by protein kinase C. FEBS Lett. 1992;296:135–140
  28. Romani A, Marfella C, Scarpa A. Regulation of magnesium uptake and release in the heart and in isolated ventricular myocytes. Circ Res. 1993;72:1139–1148
  29. Romani A, Scarpa A. Regulation of cellular magnesium. Front Biosci. 2000;5:D720–D734
  30. Stuiver I, Ruggieri Z, Smith JW. Divalent cations regulate the organization of integrins alpha v beta 3 and alpha v beta 5 on the cell surface. J Cell Physiol. 1996;168:521–531
  31. Tashiro M, Konishi M. Na+ gradient-dependent Mg2+ transport in smooth muscle cells of guinea pig tenia cecum. Biophys J. 1997;73:3371–3384
  32. Terasaki M, Rubin H. Evidence that intracellular magnesium is present in cells at a regulatory concentration for protein synthesis. Proc Natl Acad Sci U S A. 1985;82:7324–7326
  33. Tessman PA, Romani A. Acute effect of EtOH on Mg2+ homeostasis in liver cells: Evidence for the activation of an Na+/Mg2+ exchanger. Am J Physiol. 1998;275:G1106–G1116
  34. Touyz RM, Schiffrin EL. Angiotensin II and vasopressin modulate intracellular free magnesium in vascular smooth muscle cells through Na+-dependent protein kinase C pathways. J Biol Chem. 1996;271:24353–24358
  35. Voels T, Nillieus B, Hoefs S, van der Kemp AWCM, Droogmans G, Bindels RJM, et al. TRPM6 forms the Mg2+ influx channel involved in intestinal and renal Mg2+ absorption. J Biol Chem. 2004;279:19–25
  36. Walder RY, Landau D, Meyer P, Shalev H, Tsolia M, Borochowitz Z, et al. Mutation of TRPM6 causes familial hypomagnesemia with secondary hypocalcemia. Nat Genet. 2002;31:171–174
  37. Wolf FI, Torsello A, Fasanella S, Cittadini A. Cell physiology of magnesium. Mol Asp Med. 2003;24:11–26
  38. Young A, Cefaratti C, Romani A. Chronic EtOH administration alters liver Mg2+ homeostasis. Am J Physiol. 2003;284:G57–G67
  39. Zou LY, Wu L, Altura BT, Barbour RL, Altura BM. Beneficial effects of high magnesium on alcohol induced cardiac failure. Magnes Trace Elem. 1991–1992;10:409–419

PII: S0741-8329(05)00116-3

doi: 10.1016/j.alcohol.2005.04.010

Alcohol
Volume 36, Issue 1 , Pages 5-18 , May 2005