Alcohol
Volume 36, Issue 1 , Pages 31-40 , May 2005

Malondialdehyde–acetaldehyde adducts decrease bronchial epithelial wound repair

  • Todd A. Wyatt

      Affiliations

    • Research Service, Department of Veterans Affairs Medical Center, 4101 Woolworth Avenue, Omaha, NE 68105, USA
    • Pulmonary and Critical Care Medicine Section, Department of Internal Medicine, University of Nebraska Medical Center, 985300 Nebraska Medical Center, Omaha, NE 68198-5300, USA
    • Corresponding Author InformationCorresponding author. Pulmonary and Critical Care Medicine Section, Department of Internal Medicine, University of Nebraska Medical Center, 985300 Nebraska Medical Center, Omaha, NE 68198-5300, USA. Tel.: +1-402-559-9101; fax: +1-402-559-6584.
    • ,
  • Kusum K. Kharbanda

      Affiliations

    • Research Service, Department of Veterans Affairs Medical Center, 4101 Woolworth Avenue, Omaha, NE 68105, USA
    • ,
  • Dean J. Tuma

      Affiliations

    • Research Service, Department of Veterans Affairs Medical Center, 4101 Woolworth Avenue, Omaha, NE 68105, USA
    • ,
  • Joseph H. Sisson

      Affiliations

    • Pulmonary and Critical Care Medicine Section, Department of Internal Medicine, University of Nebraska Medical Center, 985300 Nebraska Medical Center, Omaha, NE 68198-5300, USA
    • ,
  • John R. Spurzem

      Affiliations

    • Research Service, Department of Veterans Affairs Medical Center, 4101 Woolworth Avenue, Omaha, NE 68105, USA
    • Pulmonary and Critical Care Medicine Section, Department of Internal Medicine, University of Nebraska Medical Center, 985300 Nebraska Medical Center, Omaha, NE 68198-5300, USA

Received 24 October 2004 ,Revised 8 March 2005 ,Accepted 31 May 2005.

References 

  1. Azzi A. The role of alpha-tocopherol in preventing disease. Eur J Nutr. 2004;43(Suppl. 1):I18–I25
  2. Babitt J, Trigatti B, Rigotti A, Smart EJ, Anderson RG, Xu S, et al. Murine SR-BI, a high density lipoprotein receptor that mediates selective lipid uptake, is N-glycosylated and fatty acylated and colocalizes with plasma membrane caveolae. J Biol Chem. 1997;272:13242–13249
  3. Burgos PV, Klattenhoff C, de la Fuente E, Rigotti A, Gonzalez A. Cholesterol depletion induces PKA-mediated basolateral-to-apical transcytosis of the scavenger receptor class B type I in MDCK cells. Proc Natl Acad Sci U S A. 2004;101:3845–3850
  4. Cantral DE, Sisson JH, Veys T, Rennard SI, Spurzem JR. Effects of cigarette smoke extract on bovine bronchial epithelial cell attachment and migration. Am J Physiol (Lung Cell Mol Physiol). 1995;268:L723–L728
  5. CDC . Cigarette smoking among adults – United States, 2000. MMWR Morb Mortal Wkly Rep. 2002;51:642–645
  6. Coller SP, Paulnock DM. Signaling pathways initiated in macrophages after engagement of type A scavenger receptors. J Leukoc Biol. 2001;70:142–148
  7. De Rijke YB, Biessen EA, Vogelezang CJ, van Berkel TJ. Binding characteristics of scavenger receptors on liver endothelial and Kupffer cells for modified low-density lipoproteins. Biochem J. 1994;304(Pt 1):69–73
  8. Fukuhara-Takaki K, Sakai M, Sakamoto Y, Takeya M, Horiuchi S. Expression of class A scavenger receptor is enhanced by high glucose in vitro and under diabetic conditions in vivo: one mechanism for an increased rate of atherosclerosis in diabetes. J Biol Chem. 2005;280:3355–3364
  9. Grewal T, de Diego I, Kirchhoff MF, Tebar F, Heeren J, Rinninger F, et al. High density lipoprotein-induced signaling of the MAPK pathway involves scavenger receptor type BI-mediated activation of Ras. J Biol Chem. 2003;278:16478–16481
  10. Gschwendt M, Muller HJ, Kielbassa K, Zang R, Kittstein W, Rincke G, et al. Rottlerin, a novel protein kinase inhibitor. Biochem Biophys Res Commun. 1994;199:93–98
  11. Hannun YA, Loomis CR, Bell RM. Activation of protein kinase C by Triton X-100 mixed micelles containing diacylglycerol and phosphatidylserine. J Biol Chem. 1985;260:10039–10043
  12. Heinemann HO. Alcohol and the lung. A brief review. Am J Med. 1977;63:81–85
  13. Hill GE, Miller JA, Baxter BT, Klassen LW, Duryee MJ, Tuma DJ, et al. Association of malondialdehyde–acetaldehyde (MAA) adducted proteins with atherosclerotic-induced vascular inflammatory injury. Atherosclerosis. 1998;141:107–116
  14. Hsu HY, Chiu SL, Wen MH, Chen KY, Hua KF. Ligands of macrophage scavenger receptor induce cytokine expression via differential modulation of protein kinase signaling pathways. J Biol Chem. 2001;276:28719–28730
  15. Kearley ML, Patel A, Chien J, Tuma DJ. Observation of a new nonfluorescent malondialdehyde–acetaldehyde-protein adduct by 13C NMR spectroscopy. Chem Res Toxicol. 1999;12:100–105
  16. Kharbanda KK, Shubert KA, Wyatt TA, Sorrell MF, Tuma DJ. Effect of malondialdehyde–acetaldehyde–protein adducts on the protein kinase C-dependent secretion of urokinase-type plasminogen activator in hepatic stellate cells. Biochem Pharmacol. 2002;63:553–562
  17. Kharbanda KK, Todero SL, Shubert KA, Sorrell MF, Tuma DJ. Malondialdehyde–acetaldehyde–protein adducts increase secretion of chemokines by rat hepatic stellate cells. Alcohol. 2001;25:123–128
  18. Kim JS, McKinnis VS, Nawrocki A, White SR. Stimulation of migration and wound repair of guinea-pig airway epithelial cells in response to epidermal growth factor. Am J Respir Cell Mol Biol. 1998;18:66–74
  19. Kolleck I, Schlame M, Fechner H, Looman AC, Wissel H, Rustow B. HDL is the major source of vitamin E for type II pneumocytes. Free Radic Biol Med. 1999;27:882–890
  20. Lechner JF, LaVeck MA. A serum-free method for culturing normal human bronchial epithelial cells at clonal density. J Tissue Cult Methods. 1985;9:43–48
  21. Martiny-Baron G, Kazanietz MG, Mischak H, Blumberg PM, Kochs G, Hug H, et al. Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976. J Biol Chem. 1993;268:9194–9197
  22. Mietus-Snyder M, Friera A, Glass CK, Pitas RE. Regulation of scavenger receptor expression in smooth muscle cells by protein kinase C: a role for oxidative stress. Arterioscler Thromb Vasc Biol. 1997;17:969–978
  23. Miller NS, Gold MS. Comorbid cigarette and alcohol addiction: epidemiology and treatment. J Addict Dis. 1998;17:55–66
  24. Napolitano M, Bravo E. Activation of protein kinase C by phorbol esters in human macrophages reduces the metabolism of modified LDL by down-regulation of scavenger receptor activity. Int J Biochem Cell Biol. 2003;35:1127–1143
  25. NIAAA (1995). Alcohol and Tobacco: From Basic Science to Clinical Practice. NIAAA Monograph No. 30 NIH Pub. No. 95-3931, 17–36.
  26. Patten CA, Martin JE, Owen N. Can psychiatric and chemical dependency treatment units be smoke free?. J Subst Abuse Treat. 1996;13:107–118
  27. Ritter M, Buechler C, Kapinsky M, Schmitz G. Interaction of CD163 with the regulatory subunit of casein kinase II (CKII) and dependence of CD163 signaling on CKII and protein kinase C. Eur J Immunol. 2001;31:999–1009
  28. Roskoski R. Assays of protein kinase. Methods Enzymol. 1983;99:3–6
  29. Schneiderhan W, Schmid-Kotsas A, Zhao J, Grunert A, Nussler A, Weidenbach H, et al. Oxidized low-density lipoproteins bind to the scavenger receptor, CD36, of hepatic stellate cells and stimulate extracellular matrix synthesis. Hepatology. 2001;34:729–737
  30. Shoji S, Rickard KA, Ertl RF, Linder J, Rennard SI. Lung fibroblasts produce chemotactic factors for bronchial epithelial cells. Am J Physiol. 1989;257:L71–L79
  31. Spurzem JR, Gupta J, Veys T, Kneifl KR, Rennard SI, Wyatt TA. Activation of protein kinase A accelerates bovine bronchial epithelial cell migration. Am J Physiol Lung Cell Mol Physiol. 2002;282:L1108–L1116
  32. Steinbrecher UP, Lougheed M, Kwan WC, Dirks M. Recognition of oxidized low density lipoprotein by the scavenger receptor of macrophages results from derivatization of apolipoprotein B by products of fatty acid peroxidation. J Biol Chem. 1989;264:15216–15223
  33. Suadicani P, Hein HO, Meyer HW, Gyntelberg F. Exposure to cold and draught, alcohol consumption, and the NS-phenotype are associated with chronic bronchitis: an epidemiological investigation of 3387 men aged 53–75 years: the Copenhagen Male Study. Occup Environ Med. 2001;58:160–164
  34. Sugiyama S, Kugiyama K, Ohgushi M, Fujimoto K, Yasue H. Lysophosphatidylcholine in oxidized low-density lipoprotein increases endothelial susceptibility to polymorphonuclear leukocyte-induced endothelial dysfunction in porcine coronary arteries. Role of protein kinase C. Circ Res. 1994;74:565–575
  35. Tabak C, Smit HA, Rasanen L, Fidanza F, Menotti A, Nissinen A, et al. Alcohol consumption in relation to 20-year COPD mortality and pulmonary function in middle-aged men from three European countries. Epidemiology. 2001;12:239–245
  36. Terpstra V, van Amersfoort ES, van Velzen AG, Kuiper J, van Berkel TJ. Hepatic and extrahepatic scavenger receptors: function in relation to disease. Arterioscler Thromb Vasc Biol. 2000;20:1860–1872
  37. Thiele GM, Tuma DJ, Willis MS, Miller JA, McDonald TL, Sorrell MF, et al. Soluble proteins modified with acetaldehyde and malondialdehyde are immunogenic in the absence of adjuvant. Alcohol Clin Exp Res. 1998;22:1731–1739
  38. Tuma DJ. Role of malondialdehyde–acetaldehyde adducts in liver injury. Free Radic Biol Med. 2002;32:303–308
  39. Tuma DJ, Smith TE, Schaffert CS, Kharbanda KK, Sorrell MF. Ethanol feeding selectively impairs the spreading of rat perivenous hepatocytes on extracellular matrix substrates. Alcohol Clin Exp Res. 1999;23:1673–1680
  40. Tuma DJ, Thiele GM, Xu D, Klassen LW, Sorrell MF. Acetaldehyde and malondialdehyde react together to generate distinct protein adducts in the liver during long-term ethanol administration. Hepatology. 1996;23:872–880
  41. Wang H, Liu X, Umino T, Skold CM, Zhu Y, Kohyama T, et al. Cigarette smoke inhibits human bronchial epithelial cell repair processes. Am J Respir Cell Mol Biol. 2001;25:772–779
  42. Way KJ, Chou E, King GL. Identification of PKC-isoform-specific biological actions using pharmacological approaches. Trends Pharmacol Sci. 2000;21:181–187
  43. Williams GD, Stinson FS, Parker DA, Harford TC, Noble J. Epidemioiogic Bulletin No. 15: Demographic trends. alcohol abuse and alcoholism, 1985–1995. Alcohol Health Res World. 1987;11:80–83
  44. Witt W, Kolleck I, Fechner H, Sinha P, Rustow B. Regulation by vitamin E of the scavenger receptor BI in rat liver and HepG2 cells. J Lipid Res. 2000;41:2009–2016
  45. Wu R, Groelke JW, Chang LY, Proter ME, Smith D, Nettesheim P. Effects of hormones on the multiplication and differentiation of tracheal epithelial cells in culture. In:  Sirbasku DA,  Sato GH,  Pardee AB editor. Growth of Cells in Hormonally Defined Media. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory; 1982;p. 641–656
  46. Wyatt TA, Ito H, Veys TJ, Spurzem JR. Stimulation of protein kinase C activity by tumor necrosis factor-alpha in bovine bronchial epithelial cells. Am J Physiol. 1997;273:L1007–L1012
  47. Wyatt TA, Kharbanda KK, Tuma DJ, Sisson JH. Malondialdehyde–acetaldehyde-adducted bovine serum albumin activates protein kinase C and stimulates interleukin-8 release in bovine bronchial epithelial cells. Alcohol. 2001;25:159–166
  48. Wyatt TA, Schmidt SC, Rennard SI, Sisson JH. Acetaldehyde-stimulated PKC activity in airway epithelial cells treated with smoke extract from normal and smokeless cigarettes. Proc Soc Exp Biol Med. 2000;225:91–97
  49. Xu D, Thiele GM, Kearley ML, Haugen MD, Klassen LW, Sorrell MF, et al. Epitope characterization of malondialdehyde–acetaldehyde adducts using an enzyme-linked immunosorbent assay. Chem Res Toxicol. 1997;10:978–986
  50. Zahm JM, Kaplan H, Herard AL, Doriot F, Pierrot D, Somelette P, et al. Cell migration and proliferation during the in vitro wound repair of the respiratory epithelium. Cell Motil Cytoskeleton. 1997;37:33–43
  51. Zhang H, Loney LA, Potter BJ. Effect of chronic alcohol feeding on hepatic iron status and ferritin uptake by rat hepatocytes. Alcohol Clin Exp Res. 1993;17:394–400
  52. Zhou G, Seibenhener ML, Wooten MW. Nucleolin is a protein kinase C-zeta substrate. Connection between cell surface signaling and nucleus in PC12 cells. J Biol Chem. 1997;272:31130–31137

PII: S0741-8329(05)00118-7

doi: 10.1016/j.alcohol.2005.06.002

Alcohol
Volume 36, Issue 1 , Pages 31-40 , May 2005

Article Tools

* Image Usage & Resolution