Alcohol
Volume 36, Issue 2 , Pages 117-125 , June 2005

Evolution of the DRD2 gene haplotype and its association with alcoholism in Mexican Americans

  • Huai-Rong Luo

      Affiliations

    • Department of Pharmacology, Toxicology & Therapeutics, Breidenthal Building, Mail Stop 1018, The University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66160-7417, USA
    • ,
  • Zhen-Fang Hou

      Affiliations

    • Laboratory of Conservation and Utilization of Bio-resource, Yunnan University, Kunming 650091, PR China
    • ,
  • Julia Wu

      Affiliations

    • Department of Pharmacology, Toxicology & Therapeutics, Breidenthal Building, Mail Stop 1018, The University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66160-7417, USA
    • ,
  • Ya-Ping Zhang

      Affiliations

    • Laboratory of Conservation and Utilization of Bio-resource, Yunnan University, Kunming 650091, PR China
    • Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, PR China
    • ,
  • Yu-Jui Yvonne Wan

      Affiliations

    • Department of Pharmacology, Toxicology & Therapeutics, Breidenthal Building, Mail Stop 1018, The University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66160-7417, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1-913-588-9111; Lab: +1-913-588-9112; fax: +1-913-588-7501.

Received 5 April 2005 ,Revised 1 September 2005 ,Accepted 8 September 2005.

References 

  1. Ajioka RS, Jorde LB, Gruen JR, Yu P, Dimitrova D, Barrow J, et al. Haplotype analysis of hemochromatosis: evaluation of different linkage-disequilibrium approaches and evolution of disease chromosomes. Am J Hum Genet. 1997;60:1439–1447
  2. Amadeo S, Abbar M, Fourcade ML, Waksman G, Leroux MG, Madec A, et al. D2 dopamine receptor gene and alcoholism. J Psychiatr Res. 1993;27:173–179
  3. Arinami T, Gao M, Hamaguchi H, Toru M. A functional polymorphism in the promoter region of the dopamine D2 receptor gene is associated with schizophrenia. Hum Mol Genet. 1997;6:577–582
  4. Arinami T, Itokawa M, Komiyama T, Mitsushio H, Mori H, Mifune H, et al. Association between severity of alcoholism and the A1 allele of the dopamine D2 receptor gene TaqI A RFLP in Japanese. Biol Psychiatry. 1993;33:108–114
  5. Blum K, Noble EP, Sheridan PJ, Montgomery A, Ritchie T, Jagadeeswaran P, et al. Allelic association of human dopamine D2 receptor gene in alcoholism. JAMA. 1990;263:2055–2060
  6. Blum K, Noble EP, Sheridan PJ, Montgomery A, Ritchie T, Ozkaragoz T, et al. Genetic predisposition in alcoholism: association of the D2 dopamine receptor TaqI B1 RFLP with severe alcoholics. Alcohol. 1993;10:59–67
  7. Blum K, Sheridan PJ, Wood RC, Braverman ER, Chen TJ, Comings DE. Dopamine D2 receptor gene variants: association and linkage studies in impulsive–addictive–compulsive behaviour. Pharmacogenetics. 1995;5:121–141
  8. Bowirrat A, Oscar-Berman M. Relationship between dopaminergic neurotransmission, alcoholism, and reward deficiency syndrome. Am J Med Genet. 2004;132:29–37
  9. Bureau of the Census . Statistical Abstract of the United States, 2000. Washington, DC: US Government Printing Office; 2000;
  10. Caetano R. Alcohol-related health disparities and treatment-related epidemiological findings among whites, blacks, and Hispanics in the United States. Alcohol Clin Exp Res. 2003;27:1337–1339
  11. Chen WJ, Lu ML, Hsu YP, Chen CC, Yu JM, Cheng AT. Dopamine D2 receptor gene and alcoholism among four aboriginal groups and Han in Taiwan. Am J Med Genet. 1997;74:129–136
  12. Comings DE, Comings BG, Muhleman D, Dietz G, Shahbahrami B, Tast D, et al. The dopamine D2 receptor locus as a modifying gene in neuropsychiatric disorders. JAMA. 1991;26:1793–1800
  13. Cubells JF, Kobayashi K, Nagatsu T, Kidd KK, Kidd JR, Calafell F, et al. Population genetics of a functional variant of the dopamine beta-hydroxylase gene (DBH). Am J Med Genet. 1997;74:374–379
  14. Finckh U, Rommelspacher H, Kuhn S, Dufeu P, Otto G, Heinz A, et al. Influence of the dopamine D2 receptor (DRD2) genotype on neuroadaptive effects of alcohol and the clinical outcome of alcoholism. Pharmacogenetics. 1997;7:271–281
  15. Gelernter J, Kranzler H. D2 dopamine receptor gene (DRD2) allele and haplotype frequencies in alcohol dependent and control subjects: no association with phenotype or severity of phenotype. Neuropsychopharmacology. 1999;20:640–649
  16. Gelernter J, Kranzler H, Cubells JF, Ichinose H, Nagatsu T. DRD2 allele frequencies and linkage disequilibria, including the −141CIns/Del promoter polymorphism, in European-American, African-American, and Japanese subjects. Genomics. 1998;51:21–26
  17. Gelernter J, O'Malley S, Risch N, Kranzler HR, Krystal J, Merikangas K, et al. No association between an allele at the D2 dopamine receptor gene (DRD2) and alcoholism. JAMA. 1991;266:1801–1807
  18. Goldman D, Dean M, Brown GL, Bolos AM, Tokola R, Virkkunen M, et al. D2 dopamine receptor genotype and cerebrospinal fluid homovanillic acid, 5-hydroxyindoleacetic acid and 3-methoxy-4-hydroxyphenylglycol in alcoholics in Finland and the United States. Acta Psychiatr Scand. 1992;86:351–357
  19. Hauge XY, Grandy DK, Eubanks JH, Evans GA, Civelli O, Litt M. Detection and characterization of additional DNA polymorphisms in the dopamine D2 receptor gene. Genomics. 1991;10:527–530
  20. Ishiguro H, Arinami T, Saito T, Akazawa S, Enomoto M, Mitushio H, et al. Association study between the −141C Ins/Del and TaqI A polymorphisms of the dopamine D2 receptor gene and alcoholism. Alcohol Clin Exp Res. 1998;22:845–848
  21. Iyengar S, Seaman M, Deinard AS, Rosenbaum HC, Sirugo G, Castiglione CM, et al. Analyses of cross species polymerase chain reaction products to infer the ancestral state of human polymorphisms. DNA Seq. 1998;8:317–327
  22. Jones KW, Peroutka SJ. Step-wise analysis of polymorphisms in the human dopamine D2 receptor gene. Neuropharmacology. 1998;37:803–814
  23. Jonsson EG, Nothen MM, Grunhage F, Farde L, Nakashima Y, Propping P, et al. Polymorphisms in the dopamine D2 receptor gene and their relationships to striatal dopamine receptor density of healthy volunteers. Mol Psychiatry. 1999;4:290–296
  24. Kidd KK, Morar B, Castiglione CM, Zhao H, Pakstis AJ, Speed WC, et al. A global survey of haplotype frequencies and linkage disequilibrium at the DRD2 locus. Hum Genet. 1998;103:211–227
  25. Kidd KK, Pakstis AJ, Castiglione CM, Kidd JR, Speed WC, Goldman D, et al. DRD2 haplotypes containing the TaqI A1 allele: implications for alcoholism research. Alcohol Clin Exp Res. 1996;20:697–705
  26. Konishi T, Calvillo M, Leng AS, Lin KM, Wan YJ. Polymorphisms of the dopamine D2 receptor, serotonin transporter, and GABA(A) receptor beta(3) subunit genes and alcoholism in Mexican-Americans. Alcohol. 2004;32:45–52
  27. Konishi T, Luo HR, Calvillo M, Mayo MS, Lin KM, Wan YJ. ADH1B∗1, ADH1C∗2, DRD2 (−141C Ins), and 5-HTTLPR are associated with alcoholism in Mexican American men living in Los Angeles. Alcohol Clin Exp Res. 2004;28:1145–1152
  28. Lahiri DK, Nurnberger JI. A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies. Nucleic Acids Res. 1991;19:5444
  29. Lee DJ, Markides KS, Ray LA. Epidemiology of self reported past heavy drinking in Hispanic adults. Ethn Health. 1997;2:77–88
  30. Lewontin RC, Kojima K. The evolutionary dynamics of complex polymorphism. Evolution. 1960;14:450–472
  31. Lucht MJ, Kuehn KU, Schroeder W, Armbruster J, Abraham G, Schattenberg A, et al. Influence of the dopamine D2 receptor (DRD2) exon 8 genotype on efficacy of tiapride and clinical outcome of alcohol withdrawal. Pharmacogenetics. 2001;11:647–653
  32. Neville MJ, Johnstone EC, Walton RT. Identification and characterization of ANKK1: a novel kinase gene closely linked to DRD2 on chromosome band 11q23.1. Hum Mutat. 2004;23:540–545
  33. Noble EP. The D2 dopamine receptor gene: a review of association studies in alcoholism and phenotypes. Alcohol. 1998;16:33–45
  34. Noble EP. D2 dopamine receptor gene in psychiatric and neurologic disorders and its phenotypes. Am J Med Genet. 2003;116:103–125
  35. Noble EP, Zhan X, Ritchie TL, Sparkes RS. Haplotypes at the DRD2 locus and severe alcoholism. Am J Med Genet. 2000;96:622–631
  36. Osier MV, Cheung KH, Kidd JR, Pakstis AJ, Miller PL, Kidd KK. ALFRED: an allele frequency database for anthropology. Am J Phys Anthropol. 2002;119:77–83
  37. Parsian A, Cloninger CR, Zhang ZH. Functional variant in the DRD2 receptor promoter region and subtypes of alcoholism. Am J Med Genet. 2000;96:407–411
  38. Parsian A, Todd RD, Devor EJ, O'Malley KL, Suarez BK, Reich T, et al. Alcoholism and alleles of the human D2 dopamine receptor locus. Studies of association and linkage. Arch Gen Psychiatry. 1991;48:655–663
  39. Reich DE, Cargill M, Bolk S, Ireland J, Sabeti PC, Richter DJ, et al. Linkage disequilibrium in the human genome. Nature. 2001;411:199–204
  40. Samochowiec J, Ladehoff M, Pelz J, Smolka M, Schmidt LG, Rommelspacher H, et al. Predominant influence of the 3′-region of dopamine D2 receptor gene (DRD2) on the clinical phenotype in German alcoholics. Pharmacogenetics. 2000;10:471–475
  41. Sander T, Ladehoff M, Samochowiec J, Finckh U, Rommelspacher H, Schmidt LG. Lack of an allelic association between polymorphisms of the dopamine D2 receptor gene and alcohol dependence in the German population. Alcohol Clin Exp Res. 1999;4:578–581
  42. Sarkar G, Kapelner S, Grandy DK, Marchionni M, Civelli O, Sobell J, et al. Direct sequencing of the dopamine D2 receptor (DRD2) in schizophrenics reveals three polymorphisms but no structural change in the receptor. Genomics. 1991;11:8–14
  43. Schneider, S., Roessli, D., & Excoffier, L. (2000). ARLEQUIN ver 2.0: a software for population genetic data analysis. Switzerland: University of Geneva.
  44. Slatkin M, Excoffier L. Testing for linkage disequilibrium in genotypic data using the Expectation-Maximization algorithm. Heredity. 1996;76:377–383
  45. Stephens M, Smith NJ, Donnelly P. A new statistical method for haplotype reconstruction from population data. Am J Hum Genet. 2001;68:978–989
  46. Takahashi, A., Hayasaka, I., Noaki, Y., & Saitou, N. (2002). Dopamine receptor D2 (DRD2) gene in Pan troglodytes. Published in GenBank (No. AB080603S7).
  47. Turner E, Ewing J, Shilling P, Smith TL, Lrwin M, Schuckit M, et al. Lack of association between an RFLP near the D2 dopamine receptor gene and severe alcoholism. Biol Psychiatry. 1992;31:285–290
  48. Zhang K, Qin Z, Chen T, Liu JS, Waterman MS, Sun F. HapBlock: haplotype block partitioning and tag SNP selection software using a set of dynamic programming algorithms. Bioinformatics. 2005;21:131–134

PII: S0741-8329(05)00148-5

doi: 10.1016/j.alcohol.2005.09.003

Alcohol
Volume 36, Issue 2 , Pages 117-125 , June 2005

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