Alcohol
Volume 37, Issue 1 , Pages 1-8 , August 2005

Differences in IL-10 and IL-12 production patterns and differences in the effects of acute ethanol treatment on macrophages in vivo and in vitro

Received 6 May 2005 ,Revised 20 September 2005 ,Accepted 26 September 2005.

References 

  1. Arbabi S, Garcia I, Bauer GJ, Maier RV. Alcohol (ethanol) inhibits IL-8 and TNF: role of the p38 pathway. J Immunol. 1999;162(12):7441–7445
  2. Carson EJ, Pruett SB. Development and characterization of a binge drinking model in mice for evaluation of the immunological effects of ethanol. Alcohol Clin Exp Res. 1996;20:132–138
  3. Chong IW, Lin SR, Hwang JJ, Huang MS, Wang TH, Tsai MS, et al. Expression and regulation of macrophage inflammatory protein-2 gene by vanadium in mouse macrophages. Inflammation. 2000;24(2):127–139
  4. Connor TJ, Kelly JP. Fenfluramine-induced immunosuppression: an in vivo analysis. Eur J Pharmacol. 2002;455(2–3):175–185
  5. Doyle SE, O'Connell R, Vaidya SA, Chow EK, Yee K, Cheng G. Toll-like receptor 3 mediates a more potent antiviral response than toll-like receptor 4. J Immunol. 2003;170(7):3565–3571
  6. Dumont JE, Dremier S, Pirson I, Maenhaut C. Cross signaling, cell specificity, and physiology. Am J Physiol Cell Physiol. 2002;283(1):C2–C28
  7. Fox ES, Cantrell CH, Leingang KA. Inhibition of the Kupffer cell inflammatory response by acute ethanol: NF-kappa B activation and subsequent cytokine production. Biochem Biophys Res Commun. 1996;225(1):134–140
  8. Friedman A, Beller DI. The effect of adherence on the in vitro induction of cytocidal activity by macrophages. Immunology. 1987;61:469–474
  9. Girouard L, Mandrekar P, Catalano D, Szabo G. Regulation of monocyte interleukin-12 production by acute alcohol: a role for inhibition by interleukin-10. Alcohol Clin Exp Res. 1998;22:211–216
  10. Goral J, Choudhry MA, Kovacs EJ. Acute ethanol exposure inhibits macrophage IL-6 production: role of p38 and ERK1/2 MAPK. J Leukoc Biol. 2003;(Nov 21, online)
  11. Hansen MB, Nielsen SE, Berg K. Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill. J Immunol Methods. 1989;119:203–210
  12. Held TK, Weihua X, Yuan L, Kalvakolanu DV, Cross AS. Gamma interferon augments macrophage activation by lipopolysaccharide by two distinct mechanisms, at the signal transduction level and via an autocrine mechanism involving tumor necrosis factor alpha and interleukin-1. Infect Immun. 1999;67(1):206–212
  13. Hemmi H, Takeuchi O, Kawai T, Kaisho T, Sato S, Sanjo H, et al. A Toll-like receptor recognizes bacterial DNA. Nature. 2000;408(6813):740–745
  14. Hirano S, Kanno S. Syk and paxillin are differentially phosphorylated following adhesion to the plastic substrate in rat alveolar macrophages. Immunology. 1999;97(3):414–419
  15. Hoebe K, Beutler B. LPS, dsRNA and the interferon bridge to adaptive immune responses: Trif, Tram, and other TIR adaptor proteins. J Endotoxin Res. 2004;10(2):130–136
  16. Katayama T, Hayashi Y, Nagahira K, Konishi K, Yamaichi K, Oikawa S. Imidocarb, a potent anti-protozoan drug, up-regulates interleukin-10 production by murine macrophages. Biochem Biophys Res Commun. 2003;309(2):414–418
  17. Krutzik PO, Hale MB, Nolan GP. Characterization of the murine immunological signaling network with phosphospecific flow cytometry. J Immunol. 2005;175(4):2366–2373
  18. Lampa J, Klareskog L, Ronnelid J. Effects of gold on cytokine production in vitro; increase of monocyte dependent interleukin 10 production and decrease of interferon-gamma levels. J Rheumatol. 2002;29(1):21–28
  19. Lawlor ER, Scheel C, Irving J, Sorensen PH. Anchorage-independent multi-cellular spheroids as an in vitro model of growth signaling in Ewing tumors. Oncogene. 2002;21(2):307–318
  20. Mandrekar P, Catalano D, Girouard L, Szabo G. Human monocyte IL-10 production is increased by acute ethanol treatment. Cytokine. 1996;8(7):567–577
  21. Mason CM, Dobard E, Kolls JK, Nelson S. Ethanol and murine interleukin (IL)-12 production. Alcohol Clin Exp Res. 2000;24(4):553–559
  22. Mengozzi M, Fantuzzi G, Faggioni R, Marchant A, Goldman M, Orencole S, et al. Chlorpromazine specifically inhibits peripheral and brain TNF production, and up-regulates IL-10 production, in mice. Immunology. 1994;82(2):207–210
  23. Monick MM, Powers L, Butler N, Yarovinsky T, Hunninghake GW. Interaction of matrix with integrin receptors is required for optimal LPS-induced MAP kinase activation. Am J Physiol Lung Cell Mol Physiol. 2002;283(2):L390–L402
  24. Nakatani Y, Fukui H, Kitazawa T, Fujimoto M, Yamao J, Uemura M. Effect of alcohol on the secretion of tumor necrosis factor-alpha by macrophages in the presence of rat serum. Alcohol Clin Exp Res. 2002;26(8 Suppl.):81S–85S
  25. Nemeth ZH, Hasko G, Vizi ES. Pyrrolidine dithiocarbamate augments IL-10, inhibits TNF-alpha, MIP-1alpha, IL-12, and nitric oxide production and protects from the lethal effect of endotoxin. Shock. 1998;10(1):49–53
  26. Patierno SR, Costa M, Lewis VM, Peavy DL. Inhibition of LPS toxicity for macrophages by metallothionein-inducing agents. J Immunol. 1983;130(4):1924–1929
  27. Petro TM. Modulation of IL-12 p35 and p40 promoter activity by smokeless tobacco extract is associated with an effect upon activation of NF-kappaB but not IRF transcription factors. Int Immunopharmacol. 2003;3(5):735–745
  28. Powell MJ, Thompson SA, Tone Y, Waldmann H, Tone M. Posttranscriptional regulation of IL-10 gene expression through sequences in the 3′-untranslated region. J Immunol. 2000;165(1):292–296
  29. Pruett SB, Fan R, Zheng Q. Acute ethanol administration profoundly alters poly I:C-induced cytokine expression in mice by a mechanism that is not dependent on corticosterone. Life Sci. 2003;72(16):1825–1839
  30. Pruett SB, Schwab C, Zheng Q, Fan R. Suppression of innate immunity by ethanol: a global perspective and a new mechanism beginning with inhibition of signaling through toll-like receptor 3. J Immunol. 2004;173:2715–2724
  31. Pruett SB, Zheng Q, Fan R, Matthews K, Schwab C. Ethanol suppresses cytokine responses induced through Toll-like receptors as well as innate resistance to Escherichia coli in a mouse model for binge drinking. Alcohol. 2004;33(2):147–155
  32. Singhal PC, Reddy K, Ding G, Kapasi A, Franki N, Ranjan R, et al. Ethanol-induced macrophage apoptosis: the role of TGF-beta. J Immunol. 1999;162(5):3031–3036
  33. Tobin SW, Douville K, Benbow U, Brinckerhoff CE, Memoli VA, Arrick BA. Consequences of altered TGF-beta expression and responsiveness in breast cancer: evidence for autocrine and paracrine effects. Oncogene. 2002;21(1):108–118
  34. Ullrich SE. Dermal application of JP-8 jet fuel induces immune suppression. Toxicol Sci. 1999;52(1):61–67
  35. Urso T, Gavaler JS, Van Thiel DH. Blood ethanol levels in sober alcohol users seen in an emergency room. Life Sci. 1981;28(9):1053–1056
  36. Wu W-J, Pruett SB. Suppression of splenic natural killer cell activity in a mouse model for binge drinking. I. Direct effects of ethanol and its major metabolites are not primarily responsible for decreased natural killer cell activity. J Pharmacol Exp Ther. 1996;278:1325–1330
  37. Yi AK, Yoon JG, Yeo SJ, Hong SC, English BK, Krieg AM. Role of mitogen-activated protein kinases in CpG DNA-mediated IL-10 and IL-12 production: central role of extracellular signal-regulated kinase in the negative feedback loop of the CpG DNA-mediated Th1 response. J Immunol. 2002;168(9):4711–4720
  38. Zell T, Khoruts A, Ingulli E, Bonnevier JL, Mueller DL, Jenkins MK. Single-cell analysis of signal transduction in CD4 T cells stimulated by antigen in vivo. Proc Natl Acad Sci U S A. 2001;98(19):10805–10810

PII: S0741-8329(05)00163-1

doi: 10.1016/j.alcohol.2005.09.004

Alcohol
Volume 37, Issue 1 , Pages 1-8 , August 2005

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