Alcohol
Volume 42, Issue 4 , Pages 237-247 , June 2008

Exposure-dependent effects of ethanol on the innate immune system

  • Joanna Goral

      Affiliations

    • Department of Anatomy, Midwestern University, Downers Grove, IL, USA
    • Burn and Shock Trauma Institute, Loyola University Chicago Medical Center, 2160 South First Avenue, Maywood, IL 60513, USA
  • ,
  • John Karavitis

      Affiliations

    • Burn and Shock Trauma Institute, Loyola University Chicago Medical Center, 2160 South First Avenue, Maywood, IL 60513, USA
    • Department of Surgery, Loyola University Chicago Medical Center, 2160 South First Avenue, Maywood, IL 60513, USA
    • Department of Cell Biology, Neurobiology, and Anatomy, Loyola University Chicago Medical Center, 2160 South First Avenue, Maywood, IL 60513, USA
    • Alcohol Research Program, Loyola University Chicago Medical Center, 2160 South First Avenue, Maywood, IL 60513, USA
  • ,
  • Elizabeth J. Kovacs

      Affiliations

    • Burn and Shock Trauma Institute, Loyola University Chicago Medical Center, 2160 South First Avenue, Maywood, IL 60513, USA
    • Department of Surgery, Loyola University Chicago Medical Center, 2160 South First Avenue, Maywood, IL 60513, USA
    • Department of Cell Biology, Neurobiology, and Anatomy, Loyola University Chicago Medical Center, 2160 South First Avenue, Maywood, IL 60513, USA
    • Alcohol Research Program, Loyola University Chicago Medical Center, 2160 South First Avenue, Maywood, IL 60513, USA
    • Corresponding Author InformationCorresponding author. Loyola University Medical Center, Departments of Cell Biology, Neurobiology, and Anatomy and Surgery, 2160 South First Avenue, Building 110, Room 4237, Maywood, IL 60153, USA. Tel.: +1-708-327-2477; fax: +1-708-327-2813.

Received 2 November 2007 ,Revised 22 February 2008 ,Accepted 22 February 2008.

References 

  1. Abel EL. Effects of prenatal alcohol exposure on birth weight in rats: is there an inverted U-shaped function?. Alcohol. 1996;13:99–102
  2. Adams HG, Jordan C. Infections in the alcoholic. Med. Clin. North Am. 1984;68:179–200
  3. Apte MV, Phillips PA, Fahmy RG, Darby SJ, Rodgers SC, McCaughan GW, et al. Does alcohol directly stimulate pancreatic fibrogenesis? Studies with rat pancreatic stellate cells. Gastroenterology. 2000;118:780–794
  4. Arbabi S, Garcia I, Bauer GJ, Maier RV. Alcohol (ethanol) inhibits IL-8 and TNF: role of the p38 pathway. J. Immunol. 1999;162:7441–7445
  5. Aroor AR, Baker RC. Ethanol inhibition of phagocytosis and superoxide anion production by microglia. Alcohol. 1998;15:277–280
  6. Auerbach-Rubin F, Ottolenghi-Nightingale E. Effect of ethanol on the clearance of airborne pneumococci and the rate of pneumococcal transformations in the lung. Infect. Immun. 1971;3:688–693
  7. Averina M, Nilssen O, Arkhipovsky VL, Kalinin AG, Brox J. C-reactive protein and alcohol consumption: is there a U-shaped association? Results from a population-based study in Russia. The Arkhangelsk study. Atherosclerosis. 2006;188:309–315
  8. Bagby GJ, Zhang P, Stoltz DA, Nelson S. Suppression of the granulocyte colony-stimulating factor response to Escherichia coli challenge by alcohol intoxication. Alcohol Clin. Exp. Res. 1998;22:1740–1745
  9. Balkwill F, Coussens LM. Cancer: an inflammatory link. Nature. 2004;431:405–406
  10. Bautista AP. Chronic alcohol intoxication primes Kupffer cells and endothelial cells for enhanced CC-chemokine production and concomitantly suppresses phagocytosis and chemotaxis. Front. Biosci. 2002;7:a117–a125
  11. Bautista AP, Elliott KE. Acute ethanol intoxication regulates f-met-leu-phe-induced chemotaxis and superoxide release by neutrophils and Kupffer cells through modulation of the formyl peptide receptor in the rat. Life Sci. 1994;54:721–730
  12. Blander JM. Coupling Toll-like receptor signaling with phagocytosis: potentiation of antigen presentation. Trends Immunol. 2007;28:19–25
  13. Blank SE, Pfister LJ, Gallucci RM, Meadows GG. Ethanol-induced changes in peripheral blood and splenic natural killer cells. Alcohol Clin. Exp. Res. 1993;17:561–565
  14. Boe DM, Nelson S, Zhang P, Bagby GJ. Acute ethanol intoxication suppresses lung chemokine production following infection with Streptococcus pneumoniae. J. Infect. Dis. 2001;184:1134–1142
  15. Boe DM, Nelson S, Zhang P, Quinton L, Bagby GJ. Alcohol-induced suppression of lung chemokine production and the host defense response to Streptococcus pneumoniae. Alcohol Clin. Exp. Res. 2003;27:1838–1845
  16. Briggs NC, Levine RS, Bobo LD, Haliburton WP, Brann EA, Hennekens CH. Wine drinking and risk of non-Hodgkin's lymphoma among men in the United States: a population-based case-control study. Am. J. Epidemiol. 2002;156:454–462
  17. Brodie MS, Scholz A, Weiger TM, Dopico AM. Ethanol interactions with calcium-dependent potassium channels. Alcohol Clin. Exp. Res. 2007;31:1625–1632
  18. Brown LA, Harris FL, Ping XD, Gauthier TW. Chronic ethanol ingestion and the risk of acute lung injury: a role for glutathione availability?. Alcohol. 2004;33:191–197
  19. Brown LA, Ping XD, Harris FL, Gauthier TW. Glutathione availability modulates alveolar macrophage function in the chronic ethanol-fed rat. Am. J. Physiol. Lung Cell. Mol. Physiol. 2007;292:L824–L832
  20. Calabrese EJ, Baldwin LA. Ethanol and hormesis. Crit. Rev. Toxicol. 2003;33:407–424
  21. Cao Q, Mak KM, Lieber CS. Dilinoleoylphosphatidylcholine decreases LPS-induced TNF-alpha generation in Kupffer cells of ethanol-fed rats: respective roles of MAPKs and NF-kappaB. Biochem. Biophys. Res. Commun. 2002;294:849–853
  22. Chaudhuri JD. Alcohol and the developing fetus—a review. Med. Sci. Monit. 2000;6:1031–1041
  23. Coussens LM, Werb Z. Inflammation and cancer. Nature. 2002;420:860–867
  24. Crabbe JC. Sensitivity to ethanol in inbred mice: genotypic correlations among several behavioral responses. Behav. Neurosci. 1983;97:280–289
  25. Cunningham C, Wilcockson DC, Campion S, Lunnon K, Perry VH. Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration. J. Neurosci. 2005;25:9275–9284
  26. Dai Q, Pruett SB. Ethanol suppresses LPS-induced Toll-like receptor 4 clustering, reorganization of the actin cytoskeleton, and associated TNF-alpha production. Alcohol Clin. Exp. Res. 2006;30:1436–1444
  27. Dai Q, Zhang J, Pruett SB. Ethanol alters cellular activation and CD14 partitioning in lipid rafts. Biochem. Biophys. Res. Commun. 2005;332:37–42
  28. Djousse L, Ellison RC, Beiser A, Scaramucci A, D'Agostino RB, Wolf PA. Alcohol consumption and risk of ischemic stroke: the Framingham Study. Stroke. 2002;33:907–912
  29. Dolganiuc A, Bakis G, Kodys K, Mandrekar P, Szabo G. Acute ethanol treatment modulates Toll-like receptor-4 association with lipid rafts. Alcohol Clin. Exp. Res. 2006;30:76–85
  30. Ekman G, Frankenhaeuser M, Goldberg L, Hagdahl R, Myrsten AL. Subjective and objective effects of alcohol as functions of dosage and time. Psychopharmacologia. 1964;6:399–409
  31. Ellison RC, Zhang Y, McLennan CE, Rothman KJ. Exploring the relation of alcohol consumption to risk of breast cancer. Am. J. Epidemiol. 2001;154:740–747
  32. Feldmann M, Brennan FM, Maini RN. Role of cytokines in rheumatoid arthritis. Annu. Rev. Immunol. 1996;14:397–440
  33. Fitzgerald KA, Rowe DC, Golenbock DT. Endotoxin recognition and signal transduction by the TLR4/MD2-complex. Microbes Infect. 2004;6:1361–1367
  34. Fukui H, Brauner B, Bode JC, Bode C. Plasma endotoxin concentrations in patients with alcoholic and non-alcoholic liver disease: reevaluation with an improved chromogenic assay. J. Hepatol. 1991;12:162–169
  35. Gigleux I, Gagnon J, St-Pierre A, Cantin B, Dagenais GR, Meyer F, et al. Moderate alcohol consumption is more cardioprotective in men with the metabolic syndrome. J. Nutr. 2006;136:3027–3032
  36. Goral J, Choudhry MA, Kovacs EJ. Acute ethanol exposure inhibits macrophage IL-6 production: role of p38 and ERK1/2 MAPK. J. Leukoc. Biol. 2004;75:553–559
  37. Goral J, Kovacs EJ. In vivo ethanol exposure down-regulates TLR2-, TLR4-, and TLR9-mediated macrophage inflammatory response by limiting p38 and ERK1/2 activation. J. Immunol. 2005;174:456–463
  38. Gun RT, Pratt N, Ryan P, Gordon I, Roder D. Tobacco and alcohol-related mortality in men: estimates from the Australian cohort of petroleum industry workers. Aust. N.Z.J. Public Health. 2006;30:318–324
  39. Gustot T, Lemmers A, Moreno C, Nagy N, Quertinmont E, Nicaise C, et al. Differential liver sensitization to toll-like receptor pathways in mice with alcoholic fatty liver. Hepatology. 2006;43:989–1000
  40. Gutierrez-Ruiz MC, Gomez JL, Souza V, Bucio L. Chronic and acute ethanol treatment modifies fluidity and composition in plasma membranes of a human hepatic cell line (WRL-68). Cell. Biol. Toxicol. 1995;11:69–78
  41. Hancock JF. Lipid rafts: contentious only from simplistic standpoints. Nat. Rev. Mol. Cell. Biol. 2006;7:456–462
  42. Hanna EZ, Chou SP, Grant BF. The relationship between drinking and heart disease morbidity in the United States: results from the National Health Interview Survey. Alcohol Clin. Exp. Res. 1997;21:111–118
  43. Hannigan JH, Armant DR. Alcohol in pregnancy and neonatal outcome. Semin. Neonatol. 2000;5:243–254
  44. He HT, Lellouch A, Marguet D. Lipid rafts and the initiation of T cell receptor signaling. Semin. Immunol. 2005;17:23–33
  45. Hercend T, Schmidt RE. Characteristics and uses of natural killer cells. Immunol. Today. 1988;9:291–293
  46. Hijmering ML, de Lange DW, Lorsheyd A, Kraaijenhagen RJ, van de Wiel A. Binge drinking causes endothelial dysfunction, which is not prevented by wine polyphenols: a small trial in healthy volunteers. Neth. J. Med. 2007;65:29–35
  47. Hines IN, Wheeler MD. Recent advances in alcoholic liver disease III. Role of the innate immune response in alcoholic hepatitis. Am. J. Physiol. Gastrointest. Liver Physiol. 2004;287:G310–G314
  48. Imhof A, Froehlich M, Brenner H, Boeing H, Pepys MB, Koenig W. Effect of alcohol consumption on systemic markers of inflammation. Lancet. 2001;357:763–767
  49. Janeway CA, Medzhitov R. Innate immune recognition. Annu. Rev. Immunol. 2002;20:197–216
  50. Jerrells TR, Vidlak D, Strachota JM. Alcoholic pancreatitis: mechanisms of viral infections as cofactors in the development of acute and chronic pancreatitis and fibrosis. J. Leukoc. Biol. 2007;81:430–439
  51. Joshi PC, Applewhite L, Ritzenthaler JD, Roman J, Fernandez AL, Eaton DC, et al. Chronic ethanol ingestion in rats decreases granulocyte-macrophage colony-stimulating factor receptor expression and downstream signaling in the alveolar macrophage. J. Immunol. 2005;175:6837–6845
  52. Kawai T, Akira S. TLR signaling. Cell Death Differ. 2006;13:816–825
  53. Khoruts A, Stahnke L, McClain CJ, Logan G, Allen JI. Circulating tumor necrosis factor, interleukin-1 and interleukin-6 concentrations in chronic alcoholic patients. Hepatology. 1991;13:267–276
  54. Kishore R, Hill JR, McMullen MR, Frenkel J, Nagy LE. ERK1/2 and Egr-1 contribute to increased TNF-alpha production in rat Kupffer cells after chronic ethanol feeding. Am. J. Physiol. Gastrointest. Liver Physiol. 2002;282:G6–G15
  55. Kishore R, McMullen MR, Nagy LE. Stabilization of tumor necrosis factor alpha mRNA by chronic ethanol: role of A+U-rich elements and p38 mitogen-activated protein kinase signaling pathway. J. Biol. Chem. 2001;276:41930–41937
  56. Kolls JK, Xie J, Lei D, Greenberg S, Summer WR, Nelson S. Differential effects of in vivo ethanol on LPS-induced TNF and nitric oxide production in the lung. Am. J. Physiol. 1995;268:L991–L998
  57. Kuhlmann CR, Li F, Ludders DW, Schaefer CA, Most AK, Backenkohler U, et al. Dose-dependent activation of Ca2+-activated K+ channels by ethanol contributes to improved endothelial cell functions. Alcohol Clin. Exp. Res. 2004;28:1005–1011
  58. Laurenzi GA, Guarneri JJ, Endriga RB, Carey JP. Clearance of Bacteria by the Lower Respiratory Tract. Science. 1963;142:1572–1573
  59. Lawrence T, Hageman T, Balkwill F. Cancer. Sex, cytokines, and cancer. Science. 2007;317:51–52
  60. Leach RE, Stachecki JJ, Armant DR. Development of in vitro fertilized mouse embryos exposed to ethanol during the preimplantation period: accelerated embryogenesis at subtoxic levels. Teratology. 1993;47:57–64
  61. Libby P. Inflammation in atherosclerosis. Nature. 2002;420:868–874
  62. Luchsinger JA, Tang MX, Siddiqui M, Shea S, Mayeux R. Alcohol intake and risk of dementia. J. Am. Geriatr. Soc. 2004;52:540–546
  63. Mandrekar P, Catalano D, Dolganiuc A, Kodys K, Szabo G. Inhibition of myeloid dendritic cell accessory cell function and induction of T cell anergy by alcohol correlates with decreased IL-12 production. J. Immunol. 2004;173:3398–3407
  64. Mandrekar P, Catalano D, Szabo G. Inhibition of lipopolysaccharide-mediated NFkappaB activation by ethanol in human monocytes. Int. Immunol. 1999;11:1781–1790
  65. Maurer DR, Liebman J. Effects of ethanol on in vitro ciliary motility. J. Appl. Physiol. 1988;65:1617–1620
  66. McClain C, Hill D, Schmidt J, Diehl AM. Cytokines and alcoholic liver disease. Semin. Liver Dis. 1993;13:170–182
  67. McVicker BL, Tuma DJ, Kubik JA, Hindemith AM, Baldwin CR, Casey CA. The effect of ethanol on asialoglycoprotein receptor-mediated phagocytosis of apoptotic cells by rat hepatocytes. Hepatology. 2002;36:1478–1487
  68. Messner RP, Meryhew NL, DeMaster EG. Effect of ethanol on immune clearance in mice: biphasic alteration of complement-mediated clearance with chronic ethanol ingestion. J. Lab. Clin. Med. 1993;122:506–517
  69. Morio LA, Chiu H, Sprowles KA, Laskin DL. Functional heterogeneity of rat hepatic and alveolar macrophages: effects of chonic ethanol administration. J. Leukoc. Biol. 2000;68:614–620
  70. Morton LM, Holford TR, Leaderer B, Zhang Y, Zahm SH, Boyle P, et al. Alcohol use and risk of non-Hodgkin's lymphoma among Connecticut women (United States). Cancer Causes Control. 2003;14:687–694
  71. Moss M, Guidot DM, Wong-Lambertina M, Ten Hoor T, Perez RL, Brown LA. The effects of chronic alcohol abuse on pulmonary glutathione homeostasis. Am. J. Respir.Crit. Care Med. 2000;161:414–419
  72. Nagy LE. Role of adenosine A1 receptors in inhibition of receptor-stimulated cyclic AMP production by ethanol in hepatocytes. Biochem. Pharmacol. 1994;48:2091–2096
  73. Nagy LE. Recent insights into the role of the innate immune system in the development of alcoholic liver disease. Exp. Biol. Med. (Maywood). 2003;228:882–890
  74. Nelson S, Bagby GJ, Bainton BG, Summer WR. The effects of acute and chronic alcoholism on tumor necrosis factor and the inflammatory response. J. Infect. Dis. 1989;160:422–429
  75. Nelson S, Kolls JK. Alcohol, host defence and society. Nat. Rev. Immunol. 2002;2:205–209
  76. Nelson S, Mason C, Bagby G, Summer W. Alcohol, tumor necrosis factor, and tuberculosis. Alcohol Clin. Exp. Res. 1995;19:17–24
  77. Nielsen NR, Gronbaek M. Interactions between intakes of alcohol and postmenopausal hormones on risk of breast cancer. Int J Cancer. 2008;122:1109–1113
  78. Nishiyama D, Ikejima K, Honda H, Hirose M, Takei Y, Sato N. Acute ethanol administration down-regulates toll-like receptor-4 in the murine liver. Hepatol. Res. 2002;23:130–137
  79. O'Brien JM, Lu B, Ali NA, Martin GS, Aberegg SK, Marsh CB, et al. Alcohol dependence is independently associated with sepsis, septic shock, and hospital mortality among adult intensive care unit patients. Crit. Care Med. 2007;35:345–350
  80. Oak S, Mandrekar P, Catalano D, Kodys K, Szabo G. TLR2- and TLR4-mediated signals determine attenuation or augmentation of inflammation by acute alcohol in monocytes. J. Immunol. 2006;176:7628–7635
  81. Perry VH, Cunningham C, Holmes C. Systemic infections and inflammation affect chronic neurodegeneration. Nat. Rev. Immunol. 2007;7:161–167
  82. Peters TJ, Preedy VR. Metabolic consequences of alcohol ingestion. Novartis Found. Symp. 1998;216:19–24discussion 24–34
  83. Pikarsky E, Porat RM, Stein I, Abramovitch R, Amit S, Kasem S, et al. NF-kappaB functions as a tumour promoter in inflammation-associated cancer. Nature. 2004;431:461–466
  84. Pike LJ. Lipid rafts: bringing order to chaos. J. Lipid Res. 2003;44:655–667
  85. Power C, Rodgers B, Hope S. U-shaped relation for alcohol consumption and health in early adulthood and implications for mortality. Lancet. 1998;352:877
  86. Primatesta P, Del Corno G, Bonazzi MC, Waters WE. Alcohol and pregnancy: an international comparison. J. Public Health Med. 1993;15:69–76
  87. Pruett BS, Pruett SB. An explanation for the paradoxical induction and suppression of an acute phase response by ethanol. Alcohol. 2006;39:105–110
  88. Pruett SB, Fan R, Zheng Q. Acute ethanol administration profoundly alters poly I:C-induced cytokine expression in mice by a mechanism that is not dependent on corticosterone. Life Sci. 2003;72:1825–1839
  89. Pruett SB, Schwab C, Zheng Q, Fan R. Suppression of innate immunity by acute ethanol administration: a global perspective and a new mechanism beginning with inhibition of signaling through TLR3. J. Immunol. 2004;173:2715–2724
  90. Pruett SB, Zheng Q, Fan R, Matthews K, Schwab C. Acute exposure to ethanol affects Toll-like receptor signaling and subsequent responses: an overview of recent studies. Alcohol. 2004;33:235–239
  91. Radaeva S, Sun R, Jaruga B, Nguyen VT, Tian Z, Gao B. Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in NKG2D-dependent and tumor necrosis factor-related apoptosis-inducing ligand-dependent manners. Gastroenterology. 2006;130:435–452
  92. Rao RK, Seth A, Sheth P. Recent Advances in Alcoholic Liver Disease I. Role of intestinal permeability and endotoxemia in alcoholic liver disease. Am. J. Physiol. Gastrointest. Liver Physiol. 2004;286:G881–G884
  93. Regev A, Jeffers LJ. Hepatitis C and alcohol. Alcohol Clin. Exp. Res. 1999;23:1543–1551
  94. Rehm J, Room R, Graham K, Monteiro M, Gmel G, Sempos CT. The relationship of average volume of alcohol consumption and patterns of drinking to burden of disease: an overview. Addiction. 2003;98:1209–1228
  95. Rimland D, Hand WL. The effect of ethanol on adherence and phagocytosis by rabbit alveolar macrophages. J. Lab. Clin. Med. 1980;95:918–926
  96. Rimm EB, Williams P, Fosher K, Criqui M, Stampfer MJ. Moderate alcohol intake and lower risk of coronary heart disease: meta-analysis of effects on lipids and haemostatic factors. BMJ. 1999;319:1523–1528
  97. Rodrigo R, Thielemann L, Orellana M. Acute and chronic effect of ethanol on (Na+K)-ATPase activity and cyclic AMP response to vasopressin in rat papillary collecting duct cells. Gen. Pharmacol. 1998;30:663–667
  98. Rottenberg H, Waring A, Rubin E. Tolerance and cross-tolerance in chronic alcoholics: reduced membrane binding of ethanol and other drugs. Science. 1981;213:583–585
  99. Rozman KK. Hormesis and risk assessment. Hum. Exp. Toxicol. 2005;24:255–257
  100. Ruiz M, Ewig S, Marcos MA, Martinez JA, Arancibia F, Mensa J, et al. Etiology of community-acquired pneumonia: impact of age, comorbidity, and severity. Am. J. Respir. Crit. Care Med. 1999;160:397–405
  101. Sabroe I, Read RC, Whyte MK, Dockrell DH, Vogel SN, Dower SK. Toll-like receptors in health and disease: complex questions remain. J. Immunol. 2003;171:1630–1635
  102. Saeed RW, Varma S, Peng T, Tracey KJ, Sherry B, Metz CN. Ethanol blocks leukocyte recruitment and endothelial cell activation in vivo and in vitro. J. Immunol. 2004;173:6376–6383
  103. Scheel O, Papavlassopoulos M, Blunck R, Gebert A, Hartung T, Zahringer U, et al. Cell activation by ligands of the toll-like receptor and interleukin-1 receptor family depends on the function of the large-conductance potassium channel MaxiK in human macrophages. Infect. Immun. 2006;74:4354–4356
  104. Schenker S, Montalvo R. Alcohol and the pancreas. Recent Dev. Alcohol. 1998;14:41–65
  105. Schmidt KN, Leung B, Kwong M, Zarember KA, Satyal S, Navas TA, et al. APC-independent activation of NK cells by the Toll-like receptor 3 agonist double-stranded RNA. J. Immunol. 2004;172:138–143
  106. Shacter E, Weitzman SA. Chronic inflammation and cancer. Oncology (Williston Park). 2002;16:217–226229; discussion 230–212
  107. Shiratori Y, Jin'nai H, Teraoka H, Matano S, Matsumoto K, Kamii K, et al. Phagocytic properties of hepatic endothelial cells and splenic macrophages compensating for a decreased phagocytic function of Kupffer cells in the chronically ethanol-fed rats. Exp. Cell. Biol. 1989;57:300–309
  108. Shiratori Y, Teraoka H, Matano S, Matsumoto K, Kamii K, Tanaka M. Kupffer cell function in chronic ethanol-fed rats. Liver. 1989;9:351–359
  109. Singletary KW, Gapstur SM. Alcohol and breast cancer: review of epidemiologic and experimental evidence and potential mechanisms. JAMA. 2001;286:2143–2151
  110. Sisson JH. Alcohol and airways function in health and disease. Alcohol. 2007;41:293–307
  111. Spitzer JA, Zhang P. Gender differences in phagocytic responses in the blood and liver, and the generation of cytokine-induced neutrophil chemoattractant in the liver of acutely ethanol-intoxicated rats. Alcohol Clin. Exp. Res. 1996;20:914–920
  112. Szabo G. Monocytes, alcohol use, and altered immunity. Alcohol Clin. Exp. Res. 1998;22:216S–219S
  113. Szabo G, Dolganiuc A, Dai Q, Pruett SB. TLR4, ethanol, and lipid rafts: a new mechanism of ethanol action with implications for other receptor-mediated effects. J. Immunol. 2007;178:1243–1249
  114. Szabo G, Mandrekar P, Dolganiuc A, Catalano D, Kodys K. Reduced alloreactive T-cell activation after alcohol intake is due to impaired monocyte accessory cell function and correlates with elevated IL-10, IL-13, and decreased IFNgamma levels. Alcohol Clin. Exp. Res. 2001;25:1766–1772
  115. Szabo G, Mandrekar P, Girouard L, Catalano D. Regulation of human monocyte functions by acute ethanol treatment: decreased tumor necrosis factor-alpha, interleukin-1 beta and elevated interleukin-10, and transforming growth factor-beta production. Alcohol Clin. Exp. Res. 1996;20:900–907
  116. Takeda K, Kaisho T, Akira S. Toll-like receptors. Annu. Rev. Immunol. 2003;21:335–376
  117. Thurman RG. II. Alcoholic liver injury involves activation of Kupffer cells by endotoxin. Am. J. Physiol. 1998;275:G605–G611
  118. Tolstrup J, Jensen MK, Tjonneland A, Overvad K, Mukamal KJ, Gronbaek M. Prospective study of alcohol drinking patterns and coronary heart disease in women and men. BMJ. 2006;332:1244–1248
  119. Triantafilou M, Miyake K, Golenbock DT, Triantafilou K. Mediators of innate immune recognition of bacteria concentrate in lipid rafts and facilitate lipopolysaccharide-induced cell activation. J. Cell. Sci. 2002;115:2603–2611
  120. Triantafilou M, Triantafilou K. Heat-shock protein 70 and heat-shock protein 90 associate with Toll-like receptor 4 in response to bacterial lipopolysaccharide. Biochem. Soc. Trans. 2004;32:636–639
  121. Underhill DM, Gantner B. Integration of Toll-like receptor and phagocytic signaling for tailored immunity. Microbes Infect. 2004;6:1368–1373
  122. Verma BK, Fogarasi M, Szabo G. Down-regulation of tumor necrosis factor alpha activity by acute ethanol treatment in human peripheral blood monocytes. J. Clin. Immunol. 1993;13:8–22
  123. Weck MM, Grunebach F, Werth D, Sinzger C, Bringmann A, Brossart P. TLR ligands differentially affect uptake and presentation of cellular antigens. Blood. 2007;109:3890–3894
  124. Wheeler MD, Kono H, Yin M, Nakagami M, Uesugi T, Arteel GE, et al. The role of Kupffer cell oxidant production in early ethanol-induced liver disease. Free Radic. Biol. Med. 2001;31:1544–1549
  125. Williams AF. Social drinking, anxiety, and depression. J. Pers. Soc. Psychol. 1966;3:689–693
  126. Williams ES, Mirro MJ, Bailey JC. Electrophysiological effects of ethanol, acetaldehyde, and acetate on cardiac tissues from dog and guinea pig. Circ. Res. 1980;47:473–478
  127. Winzen R, Kracht M, Ritter B, Wilhelm A, Chen CY, Shyu AB, et al. The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism. Embo J. 1999;18:4969–4980
  128. Wu WJ, Pruett SB. Suppression of splenic natural killer cell activity in a mouse model for binge drinking. I. Direct effects of ethanol and its major metabolites are not primarily responsible for decreased natural killer cell activity. J. Pharmacol. Exp. Ther. 1996;278:1325–1330
  129. Wu WJ, Pruett SB. Ethanol decreases host resistance to pulmonary metastases in a mouse model: role of natural killer cells and the ethanol-induced stress response. Int. J. Cancer. 1999;82:886–892
  130. Wyatt TA, Gentry-Nielsen MJ, Pavlik JA, Sisson JH. Desensitization of PKA-stimulated ciliary beat frequency in an ethanol-fed rat model of cigarette smoke exposure. Alcohol Clin. Exp. Res. 2004;28:998–1004
  131. Yao J, Mackman N, Edgington TS, Fan ST. Lipopolysaccharide induction of the tumor necrosis factor-alpha promoter in human monocytic cells. Regulation by Egr-1, c-Jun, and NF-kappaB transcription factors. J. Biol. Chem. 1997;272:17795–17801
  132. Yap M, Mascord DJ, Starmer GA, Whitfield JB. Studies on the chronopharmacology of ethanol. Alcohol Alcohol. 1993;28:17–24
  133. Zhang P, Bagby GJ, Xie M, Stoltz DA, Summer WR, Nelson S. Acute ethanol intoxication inhibits neutrophil beta2-integrin expression in rats during endotoxemia. Alcohol Clin. Exp. Res. 1998;22:135–141
  134. Zhang P, Nelson S, Summer WR, Spitzer JA. Acute ethanol intoxication suppresses the pulmonary inflammatory response in rats challenged with intrapulmonary endotoxin. Alcohol Clin. Exp. Res. 1997;21:773–778
  135. Zhang Y, Kreger BE, Dorgan JF, Splansky GL, Cupples LA, Ellison RC. Alcohol consumption and risk of breast cancer: the Framingham Study revisited. Am. J. Epidemiol. 1999;149:93–101
  136. Zhu X, Coleman RA, Alber C, Ballas ZK, Waldschmidt TJ, Ray NB, et al. Chronic ethanol ingestion by mice increases expression of CD80 and CD86 by activated macrophages. Alcohol. 2004;32:91–100
  137. Zuo G, Gong J, Liu C, Wu C, Li S, Dai L. Synthesis of Toll-like receptor 4 in Kupffer cells and its role in alcohol-induced liver disease. Chin. Med. J. (Engl). 2003;116:297–300

PII: S0741-8329(08)00041-4

doi: 10.1016/j.alcohol.2008.02.003

Alcohol
Volume 42, Issue 4 , Pages 237-247 , June 2008