Alcohol
Volume 42, Issue 8 , Pages 649-656 , December 2008

Binge alcohol treatment of adolescent rats followed by alcohol abstinence is associated with site-specific differences in bone loss and incomplete recovery of bone mass and strength

  • Kristen Lauing

      Affiliations

    • The Alcohol Research Program, Loyola University Stritch School of Medicine, 2160 S. First Avenue, Maywood, IL 60153, USA
  • ,
  • Ryan Himes

      Affiliations

    • Department of Orthopaedic Surgery and Rehabilitation, Loyola University Stritch School of Medicine, 2160 S. First Avenue, Maywood, IL 60153, USA
  • ,
  • Matthew Rachwalski

      Affiliations

    • University of Illinois, IL USA
  • ,
  • Patrick Strotman

      Affiliations

    • Brown University, Providence, RI USA
  • ,
  • John J. Callaci

      Affiliations

    • The Alcohol Research Program, Loyola University Stritch School of Medicine, 2160 S. First Avenue, Maywood, IL 60153, USA
    • Department of Orthopaedic Surgery and Rehabilitation, Loyola University Stritch School of Medicine, 2160 S. First Avenue, Maywood, IL 60153, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1-708-327-2461; fax: +1-708-327-2813.

Received 11 April 2008 ,Revised 12 August 2008 ,Accepted 12 August 2008.

References 

  1. Abrams SA. Normal acquisition and loss of bone mass. Horm. Res. 2003;60(Suppl 3):71–76
  2. Becker HC. Animal models of alcohol withdrawal. Alcohol Res. Health. 2000;24(2):105–113
  3. Callaci JJ, Juknelis D, Patwardhan A, Sartori M, Frost N, Wezeman FH. The effects of binge alcohol exposure on bone resorption and biomechanical and structural properties are offset by concurrent bisphosphonate treatment. Alcohol. Clin. Exp. Res. 2004;28(1):182–191
  4. Callaci JJ, Juknelis D, Patwardhan D, Wezeman FH. Binge alcohol treatment increases vertebral bone loss following ovariectomy: compensation by intermittent parathyroid hormone. Alcohol. Clin. Exp. Res. 2006;30(4):665–672
  5. Chakkalakal DA. Alcohol-induced bone loss and deficient bone repair. Alcohol. Clin. Exp. Res. 2005;29(12):2077–2090
  6. Grossberg PM, Brown DD, Fleming MF. Brief physician advice for high-risk drinking among young adults. Ann. Fam. Med. 2004;2(5):474–480
  7. Hogan HA, Sampson HW, Cashier E, Ledoux N. Alcohol consumption by young actively growing rats: a study of cortical bone histomorphometry and mechanical properties. Alcohol. Clin. Exp. Res. 1997;21(5):809–816
  8. McCarty CA, Ebel BE, Garrison MM, DiGiuseppe DL, Christakis DA, Rivara FP. Continuity of binge and harmful drinking from late adolescence to early adulthood. Pediatrics. 2004;114(3):714–719
  9. Nation JR, Burkey RT, Grover CA. Lead/ethanol interactions phamacokinetics. Alcohol. 1993;10:363–367
  10. Penland S, Hoplight B, Obernier J, Crews FT. Effects of nicotine on ethand dependence and brain damage. Alcohol. 2001;24:45–54
  11. Riggs BL, Melon LJ, Robb RA, Camp JJ, Atkinson EJ, McDaniel L, et al. A population-based assessment of rates of bone loss at multiple skeletal sites: evidence for substantial trabecular bone loss in young adult women and men. J. Bone Miner. Res. 2008;23(2):205–214
  12. Sampson HW, Chaffin C, Lange J, DeFee B. Alcohol consumption by young actively growing rats: a histomorphometric study of cancellous bone. Alcohol. Clin. Exp. Res. 1997;21(2):352–359
  13. Sampson HW, Gallager S, Lange J, Chondra W, Hogan HA. Binge drinking and bone metabolism in a young actively growing rat model. Alcohol. Clin. Exp. Res. 1999;23(7):1228–1231
  14. Sampson HW, Perks N, Champney TH, DeFee B. Alcohol consumption inhibits bone growth and development in young actively growing rats. Alcohol. Clin. Exp. Res. 1996;20(8):1375–1384
  15. Schettler AE, Gustafson EM. Osteoporosis prevention starts in adolescence. J. Am. Acad. Nurse Prac. 2004;16(7):274–282
  16. Steinke B, Patwardhan AG, Havey R, King D. Human growth hormone transgene expression increases the biomechanical structural properties of mouse vertebrae. Spine. 1999;24:1–4
  17. Wezeman FH, Emanuele MA, Emanuele NV, Moskal SF, Woods M, Suri M, et al. Chronic alcohol consumption during male rat adolescence impairs skeletal development through effects on osteoblast gene expression, bone mineral density and bone strength. Alcohol. Clin. Exp. Res. 1999;23(9):1534–1542
  18. Wezeman FH, Emanuele MA, Emanuele NV, Moskal SF, Woods M, Suri M, et al. Chronic alcohol consumption during male rat adolescence impairs skeletal development through effects on osteoblast gene expression, bone mineral density and bone strength. Alcohol. Clin. Exp. Res. 2000;23:1534–1542
  19. Wezeman FH, Juknelis D, Callaci JJ. Vitamin D and ibandronate prevent cancellous bone loss associated with binge alcohol treatment in male rats. Bone. 2007;41:639–645
  20. Wezeman FH, Juknelis D, Frost N, Callaci JJ. Spine mineral density and vertebral body height are altered by alcohol consumption in growing male and female rats. Alcohol. 2003;31:1–6
  21. Windle M. Alcohol use among adolescents and young adults. Alcohol Res. Health. 2003;27(1):79–85
  22. Wronski TJ, Cintron M, Dann LM. Temporal relationship between bone loss and increased bone turnover in ovariectomized rats. Calcif. Tissue Int. 1988;43(3):179–183
  23. Wronski TJ, Dann LM, Horner SL. Time course of vertebral osteopenia in ovariectomized rats. Bone. 1989;10(4):295–301

PII: S0741-8329(08)00302-9

doi: 10.1016/j.alcohol.2008.08.005

Alcohol
Volume 42, Issue 8 , Pages 649-656 , December 2008