Gastroprotective effect of cyanidin 3-glucoside on ethanol-induced gastric lesions in rats

Li, Chun-Ying; Xu, Hong-De; Zhao, Bing-Tian; Chang, Hyo-Ihl; Rhee, Hae-Ik

doi:10.1016/j.alcohol.2008.08.009

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Volume 42, Issue 8 , Pages 683-687, December 2008

Gastroprotective effect of cyanidin 3-glucoside on ethanol-induced gastric lesions in rats

Chun-Ying Li
- Department of Biotechnology, School of Life Sciences and Biotechnology, Korea University, Seoul 136-701, South Korea
Hong-De Xu
- Department of Veterinary Medicine, Kangwon National University, Hyoja 2 dong, Chuncheon, Gangwon 200-701, South Korea
Bing-Tian Zhao
- Department of Biotechnology, Kangwon National University, Hyoja 2 dong, Chuncheon, Gangwon 200-701, South Korea
Hyo-Ihl Chang
- Department of Biotechnology, School of Life Sciences and Biotechnology, Korea University, Seoul 136-701, South Korea
Hae-Ik Rhee
- Department of Biotechnology, Kangwon National University, Hyoja 2 dong, Chuncheon, Gangwon 200-701, South Korea
- Institute of Bioscience and Biotechnology, Kangwon National University, Hyoja 2 dong, Chuncheon, Gangwon 200-701, South Korea
- Corresponding author. Tel.: +82-33-250-6481; fax: +82-33-241-6480.

Received 21 March 2008; received in revised form 31 July 2008; accepted 25 August 2008.

Abstract

This study investigated the in vivo protective effect of cyanidin 3-glucoside (C3G) against ethanol-induced gastric lesions in rats. The experimental rats were treated with 80% ethanol after pretreatment with various doses of C3G (4 and 8mg/kg of body weight), and the control rats received only 80% ethanol. Oral pretreatment with C3G significantly inhibited the formation of ethanol-induced gastric lesions and the elevation of the lipid peroxide level. In addition, pretreatment with C3G significantly increased the level of glutathione and the activities of radical scavenging enzymes, such as superoxide dismutase, catalase, and glutathione peroxidase, in gastric tissues. These results suggest that the gastroprotective effect of C3G removes the ethanol-induced lipid peroxides and free radicals and that it may offer a potential remedy for the treatment of gastric lesions.