Alcohol
Volume 42, Issue 8 , Pages 617-621 , December 2008

Chronic intermittent exposure to ethanol during adolescence produces tolerance to the hypnotic effects of ethanol in male rats: a dose-dependent analysis

  • Douglas B. Matthews

      Affiliations

    • Department of Psychology and Neuroscience, Baylor University, One Bear Place, A328, Waco, TX 76706, USA
    • Department of Psychology, The University of Memphis, Memphis, TN 38152, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1-254-710-2239; fax: +1-254-710-3303.
    • ,
  • Kristy L. Tinsley

      Affiliations

    • Department of Psychology, The University of Memphis, Memphis, TN 38152, USA
    • ,
  • Jaime L. Diaz-Granados

      Affiliations

    • Department of Psychology and Neuroscience, Baylor University, One Bear Place, A328, Waco, TX 76706, USA
    • ,
  • Sayaka Tokunaga

      Affiliations

    • Department of Psychology, The University of Memphis, Memphis, TN 38152, USA
    • ,
  • Janelle M. Silvers

      Affiliations

    • Department of Psychology, The University of Memphis, Memphis, TN 38152, USA

Received 2 January 2008 ,Revised 26 August 2008 ,Accepted 10 September 2008.

References 

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  2. Khisti RT, VanDoren MJ, O'Buckley T, Morrow AL. Neuroactive steroid 3α-hydroxy-5α-pregnan-20-one modulates ethanol-induced loss of righting reflex in rats. Brain Res. 2003;980:255–265
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  5. Silveri MM, Spear LP. Acute, rapid and chronic tolerance during ontogeny: observations when equating ethanol perturbation across age. Alcohol. Clin. Exp. Res. 2001;25:1301–1308
  6. Silvers JM, Tokunaga S, Mittleman G, Matthews DB. Chronic intermittent injections of high-dose ethanol during adolescence produce metabolic, hypnotic, and cognitive tolerance in rats. Alcohol. Clin. Exp. Res. 2003;27:1606–1612
  7. Silvers JM, Tokunaga S, Mittleman G, O'Buckley T, Morrow AL, Matthews DB. Chronic intermittent ethanol exposure during adolescence reduces the effect of ethanol challenge on hippocampal allopregnanolone levels and Morris water maze task performance. Alcohol. 2006;39:151–158
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  12. Spear LP, Varlinskaya EI. Adolescence: alcohol sensitivity, tolerance, and intake. Recent Dev. Alcohol. 2005;17:143–159
  13. Substance Abuse and Mental Health Services Administration . Results From the 2005 National Survey on Drug Use and Health: National Findings. Rockville, MD: Office of Applied Studies; 2006;NSDUH Series H-30, DHHS Publication No. SMA 06–4194
  14. Swartzwelder HS, Richardson RC, Markweise-Foerch B, Wilson WA, Little PJ. Developmental differences in the acquisition of tolerance to ethanol. Alcohol. 1998;15:311–314
  15. Tokunaga S, Silver JM, Matthews DB. Chronic intermittent ethanol exposure during adolescence blocks ethanol-induced inhibition of spontaneously active hippocampal pyramidal neurons. Alcohol. Clin. Exp. Res. 2006;30:1–6
  16. VanDoren MJ, Matthews DB, Janis GC, Grobin AC, Devaud LL, Morrow AL. Neuroactive steroid 3α-hydroxy-5α-pregnan-20-one modulates electrophysiological and behavioral actions of ethanol. J. Neurosci. 2000;20:1982–1989
  17. Varlinskaya E, Spear LP. Chronic tolerance to the social consequences of ethanol in adolescent and adult Sprague-Dawley rats. Neurotoxicol. Teratol. 2007;29:23–30
  18. White AM, Bae JG, Truesdale MC, Ahmad S, Wilson WA, Swartzwelder HS. Chronic-intermittent ethanol exposure during adolescence prevents normal developmental changes in sensitivity to ethanol-induced motor impairments. Alcohol. Clin. Exp. Res. 2002;26:960–968

PII: S0741-8329(08)00308-X

doi: 10.1016/j.alcohol.2008.09.001

Alcohol
Volume 42, Issue 8 , Pages 617-621 , December 2008

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