Alcohol
Volume 43, Issue 7 , Pages 541-543 , November 2009

Stress, alcohol craving, and relapse risk: mechanisms and viable treatment targets

  • Barbara J. Mason

      Affiliations

    • The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1-858-784-7324; fax: +1-858-784-7340.
    • ,
  • Yavin Shaham

      Affiliations

    • National Institute on Drug Abuse, Baltimore, MD, USA
    • ,
  • Friedbert Weiss

      Affiliations

    • The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    • ,
  • A.D. Le

      Affiliations

    • University of Toronto, Toronto, Ontario, Canada

Received 13 April 2009 ,Accepted 29 September 2009.

References 

  1. Aujla H, Martin-Fardon R, Weiss F. Rats with extended access to cocaine exhibit increased stress reactivity during acute and protracted abstinence. Neuropsychopharmacology. 2008;33:1818–1826
  2. Ghitza UE, Gray SM, Epstein DH, Rice KC, Shaham Y. The anxiogenic drug yohimbine reinstates palatable food seeking in a rat relapse model: a role of CRF(1) receptors. Neuropsychopharmacology. 2006;31:2188–2196
  3. Hao Y, Martin-Fardon R, Weiss F. Rats with extended access to cocaine exhibit differential sensitivity to the pharmacological actions of LY379268 and MTEP: A progressive ratio study. Program no. 359.1. 2008 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience; 2008;OnLine
  4. Le AD, Funk D, Harding S, Juzytsch W, Fletcher P. The role of noradrenaline and 5-hydroxytryptamine in yohimbine-induced increases in alcohol-seeking in rats. Psychopharmacology. 2009;204:477–488
  5. Le AD, Harding S, Juzytsch W, Funk D, Shaham Y. Role of alpha-2 adrenoceptors in stress-induced reinstatement of alcohol seeking and alcohol self-administration in rats. Psychopharmacology. 2005;179:366–373
  6. Le AD, Harding S, Watchus W, Juzytsch W, Shalev U, Shaham Y. The role of corticotropin-releasing factor in stress-induced relapse to alcohol-seeking behavior in rats. Psychopharmacology. 2000;150:317–324
  7. Marinelli PW, Funk D, Juzytsch W, Harding S, Rice KC, Shaham Y, et al. The CRF1 receptor antagonist antalarmin attenuates yohimbine-induced increases in operant alcohol self-administration and reinstatement of alcohol seeking in rats. Psychopharmacology. 2007;195:345–355
  8. Mason BJ, Light JM, Escher T, Drobes DJ. Effect of positive and negative affective stimuli and beverage cues on measures of craving in non treatment-seeking alcoholics. Psychopharmacology. 2008;200:141–150
  9. Mason BJ, Light JM, Williams LD, Drobes DJ. Proof-of-concept human laboratory study for protracted abstinence in alcohol dependence: effects of gabapentin. Addict. Biol. 2009;14:73–83
  10. Millan MJ, Newman-Tancredi A, Audinot V, Cussac D, Lejeune F, Nicolas JP, et al. Agonist and antagonist actions of yohimbine as compared to fluparoxan at alpha(2)-adrenergic receptors (AR)s, serotonin (5-HT)(1A), 5-HT(1B), 5-HT(1D) and dopamine D(2) and D(3) receptors. Significance for the modulation of frontocortical monoaminergic transmission and depressive states. Synapse. 2000;35:79–95
  11. Shaham Y, Erb S, Stewart J. Stress-induced relapse to heroin and cocaine seeking in rats: a review. Brain Res. Brain Res. Rev. 2000;33:13–33
  12. Shaham Y, Stewart J. Stress reinstates heroin self-administration behavior in drug-free animals: an effect mimicking heroin, not withdrawal. Psychopharmacology. 1995;119:334–341
  13. Sidhpura N, Martin-Fardon R, Aujla H, Weiss F. Differential effects of a mGlu5 antagonist on suppressing stress-induced reinstatement of ethanol-seeking in ethanol-dependent vs. non-dependent rats. Program no. 63.4. 2007 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience; 2007;Online
  14. Sidhpura N, Martin-Fardon R, Aujla H, Weiss F. Ethanol dependant rats show differential sensitivities to the anti-relapse effects of mGlu2/3 and mGlu5 receptors ligands. Alcohol. Clin. Exp. Res. Suppl. 2008;32:32A
  15. Wang B, Shaham Y, Zitzman D, Azari S, Wise RA, You ZB. Cocaine experience establishes control of midbrain glutamate and dopamine by corticotropin-releasing factor: a role in stress-induced relapse to drug seeking. J. Neurosci. 2005;25:5389–5396
  16. Zhao Y, Dayas CV, Aujla H, Baptista MAS, Martin-Fardon R, Weiss F. Activation of Group II metabotropic glutamate receptors attenuates both stress and cue-induced ethanol seeking and modulates c-fos expression in the hippocampus and amygdala. J. Neurosci. 2006;26:9967–9974
  17. Zhao Y, Martin-Fardon R, Aujla H, Weiss F. Effects of LY379268, a mGlu2/3 receptor agonist, on ethanol self-administration in ethanol dependent vs. non-dependent rats. Alcohol. Clin. Exp. Res. Suppl. 2007;31:85A

PII: S0741-8329(09)00150-5

doi: 10.1016/j.alcohol.2009.09.024

Alcohol
Volume 43, Issue 7 , Pages 541-543 , November 2009

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