Alcohol
Volume 44, Issue 5 , Pages 393-400, August 2010

Should mood during intravenous alcohol administration be studied as a bi- or unipolar phenomenon? a pilot study

  • Lars Saxon

      Affiliations

    • Department of Clinical Neuroscience, Section of Dependency Research, Karolinska Institute, Stockholm
    • ,
  • Stefan Skagerberg

      Affiliations

    • Swedish Prison and Probation Administration, Norrköping, Sweden
    • ,
  • Stefan Borg

      Affiliations

    • Department of Clinical Neuroscience, Section of Dependency Research, Karolinska Institute, Stockholm
    • ,
  • Arto J. Hiltunen

      Affiliations

    • Department of Psychology, Karlstad University, S-651 88 Karlstad, Sweden
    • Corresponding Author InformationCorresponding author. Tel.: +46-054-700-22-02; mobile: +46-76-845-80-35.

Received 24 April 2009; received in revised form 16 April 2010; accepted 12 May 2010. published online 21 June 2010.

Abstract 

In this study, alcohol was administered intravenously to study whether its effects on mood should preferably be studied as a bi- or unipolar phenomenon. This was studied in a double-blind, placebo-balanced, design on six healthy male volunteers. Of the three bipolar aspects of mood (calmness, activity, and pleasantness), only calmness was significantly affected by intravenous alcohol. In contrast, there were significant differences between alcohol and placebo for five of the six unipolar indexes. This support the hypothesis that subjective effects of alcohol on mood are preferably studied with self-ratings that allows positive and negative aspects to be analyzed separately. Further, our data suggest that the effects of alcohol are primarily on negative aspects of mood rather than on positive.

Keywords: Alcohol, Intravenous, Mood, Ratings, Humans

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PII: S0741-8329(10)00047-9

doi:10.1016/j.alcohol.2010.05.007

Alcohol
Volume 44, Issue 5 , Pages 393-400, August 2010

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