Alcohol
Volume 44, Issue 5 , Pages 401-406 , August 2010

Relationship between the serotonin transporter polymorphism and obsessive–compulsive alcohol craving in alcohol-dependent adults: a pilot study

  • Rachel D. Thompson

      Affiliations

    • Tri-State Tobacco and Alcohol Research Center, Addiction Sciences Division, Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA
  • ,
  • Jaimee L. Heffner

      Affiliations

    • Tri-State Tobacco and Alcohol Research Center, Addiction Sciences Division, Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    • Corresponding Author InformationCorresponding author. Tri-State Tobacco and Alcohol Research Center, University of Cincinnati Genome Research Institute, 2120 E. Galbraith Road, Building A, Cincinnati, OH 45237, USA. Tel.: +1-513-558-7187; fax: +1-513-558-7180.
  • ,
  • Judith A. Strong

      Affiliations

    • Pain Research Center, Department of Anesthesiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA
  • ,
  • Thomas J. Blom

      Affiliations

    • Tri-State Tobacco and Alcohol Research Center, Addiction Sciences Division, Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA
  • ,
  • Robert M. Anthenelli

      Affiliations

    • Tri-State Tobacco and Alcohol Research Center, Addiction Sciences Division, Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    • Cincinnati Veterans Affairs Medical Center, Cincinnati, OH, USA

Received 12 December 2009 ,Revised 27 April 2010 ,Accepted 5 May 2010.

References 

  1. Ait-Daoud N, Roache JD, Dawes MA, Liu L, Wang X, Javors MA, et al. Can serotonin transporter genotype predict craving in alcoholism?. Alcohol. Clin. Exp. Res. 2009;33:1329–1335
  2. American Psychiatric Association . DSM-5 development: alcohol-use disorder. Available at: http://www.dsm5.org/ProposedRevisions/Pages/proposedrevision.aspx?rid=4522010;Accessed April 2, 2010
  3. Anton RF. What is craving? Models and implications for treatment. Alc. Res. Health. 1999;23:165–173
  4. Anton RF, Moak DH, Latham P. The Obsessive Compulsive Drinking Scale: a self-rated instrument for the quantification of thoughts about alcohol and drinking behavior. Alcohol. Clin. Exp. Res. 1995;19:92–99
  5. Bleich S, Bonsch D, Rauh J, Bayerlein K, Fiszer R, Frieling H, et al. Association of the long allele of the 5-HTTLPR polymorphism with compulsive craving in alcohol dependence. Alcohol Alcohol. 2007;42:509–512
  6. Bloch MH, Landeros-Weisenberger A, Sen S, Dombrowski P, Kelmendi B, et al. Association of the serotonin transporter polymorphism and obsessive-compulsive disorder: systematic review. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008;147B:850–858
  7. Bohn MJ, Barton BA, Barron KA. Psychometric properties and validity of the Obsessive-Compulsive Drinking Scale. Alcohol. Clin. Exp. Res. 1996;20:817–823
  8. Bottlender M, Soyka M. Impact of craving on alcohol relapse during, and 12 months following outpatient treatment. Alcohol Alcohol. 2004;39:357–361
  9. Bottlender M, Soyka M. Efficacy of an intensive outpatient rehabilitation program in alcoholism: predictors of outcome 6 months after treatment. Eur. Addict. Res. 2005;11:132–137
  10. Bucholz KK, Cadoret R, Cloninger CR, Dinwiddie SH, Hesselbrock VM, Nurnberger JI, et al. A new, semi-structured psychiatric interview for use in genetic linkage studies: a report on the reliability of the SSAGA. J. Stud. Alcohol. 1994;55:149–158
  11. Feinn R, Nellissery M, Kranzler HR. Meta-analysis of the association of a functional serotonin transporter promoter polymorphism with alcohol dependence. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2005;133:79–84
  12. Greenberg BD, Tolliver TJ, Huang S, Li Q, Bengel D, Murphy D. Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets. Am. J. Med. Genet. 1999;88:83–87
  13. Hasin DS, Stinson FS, Ogburn E, Grant BF. Prevalence, correlates, disability, and comorbidity of DSM-IV alcohol abuse and dependence in the United States. Arch. Gen. Psychiatry. 2007;64:830–842
  14. Heffner JL, Tran GQ, Johnson CS, Barrett SW, Blom TJ, Thompson RD, et al. Combining motivational interviewing with compliance enhancement therapy (MI-CET): development and preliminary evaluation of a new, manual-guided psychosocial adjunct to alcohol dependence pharmacotherapy. J. Stud. Alcohol Drugs. 2010;71:61–70
  15. Heils A, Teufel A, Petri S, Stober G, Riederer P, Bengel D, et al. Allelic variation of human serotonin transporter gene expression. J. Neurochem. 1996;66:2621–2624
  16. Hesselbrock M, Easton C, Bucholz KK, Schuckit M, Hesselbrock V. A validity study of the SSAGA - a comparison with the SCAN. Addiction. 1999;94:1361–1370
  17. Hu X, Lipsky RH, Zhu G, Akhtar LA, Taubman J, Greenberg BD, et al. Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. Am. J. Hum. Genet. 2006;78:815–826
  18. Johnson BA. Serotonergic agents and alcoholism treatment: rebirth of the subtype concept—an hypothesis. Alcohol. Clin. Exp. Res. 2000;24:1597–1601
  19. Kaiser R, Tremblay PB, Roots I, Brockmoller J. Validity of PCR with emphasis on variable number of tandem repeat analysis. Clin. Biochem. 2002;35:49–56
  20. Kranzler HR, Mulgrew CL, Modesto-Lowe V, Burleson JA. Validity of the Obsessive Compulsive Drinking Scale (OCDS): does craving predict drinking behavior?. Alcohol. Clin. Exp. Res. 1999;23:108–114
  21. Le Marquand D, Pihl RO, Benkelfat C. Serotonin and alcohol intake, abuse and dependence: clinical evidence. Biol. Psychiatry. 1994;36:326–337
  22. Lin SW, Anthenelli RM. Genetic factors in the risk for substance use disorders. In:  Lowinson JH,  Ruiz P,  Millman RB,  Langrod JC editor. Substance Abuse, A Comprehensive Textbook. 4th ed.. Baltimore, MD: Lippincott, Williams and Wilkins; 2005;p. 33–47
  23. Lowman C, Hunt WA, Litten RZ, Drummond DC. Research perspectives on alcohol craving: an overview. Addiction. 2000;95:S45–S54
  24. Moak DH, Anton RF, Latham PK. Further validation of the Obsessive-Compulsive Drinking Scale (OCDS). Relationship to alcoholism severity. Am. J. Addict. 1998;7:14–23
  25. Modell JG, Glaser FB, Mountz JM, Schmaltz S, Cyr L. Obsessive and compulsive characteristics of alcohol abuse and dependence: quantification by a newly developed questionnaire. Alcohol. Clin. Exp. Res. 1992;16:266–271
  26. Parsey RV, Hastings RS, Oquendo MA, Hu X, Goldman D, Huang Y, et al. Effect of a triallelic functional polymorphism of the serotonin-transporter-linked promoter region on expression of serotonin transporter in the human brain. Am. J. Psychiatry. 2006;163:48–51
  27. Pierucci-Lagha A, Feinn R, Modesto-Lowe V, Swift R, Nellissery M, Covault J, et al. Effects of rapid tryptophan depletion on mood and urge to drink in patients with co-morbid major depression and alcohol dependence. Psychopharmacology. 2003;171:340–348
  28. Roberts JS, Anton RF, Latham PK, Moak DH. Factor structure and predictive validity of the Obsessive Compulsive Drinking Scale. Alcohol. Clin. Exp. Res. 1999;23:1484–1491
  29. Skinner HA, Allen BA. Alcohol dependence syndrome: measurement and validation. J. Abnorm. Psychol. 1982;91:199–209
  30. Sobell LC, Sobell MB. Assessment of drinking behavior. In:  Allen JP,  Wilson VB editor. Assessing Alcohol Problems: A Guide for Clinicians and Researchers. Bethesda, MD: National Institute on Alcohol Abuse and Alcoholism; 2003;p. 75–99
  31. Verheul R, Van Den Brink W, Geerlings P. A three-pathway psychobiological model of craving for alcohol. Alcohol Alcohol. 1999;34:197–222
  32. Wendland JR, Martin BJ, Kruse MR, Lesch KP, Murphy DL. Simultaneous genotyping of four functional loci of human SLC6A4, with a reappraisal of 5-HTTLPR and rs25531. Mol. Psychiatry. 2006;11:224–226
  33. Yonan AL, Palmer AA, Gilliam TC. Hardy-Weinberg disequilibrium identified genotyping error of the serotonin transporter (SLC6A4) promoter polymorphism. Psychiatr. Genet. 2006;16:31–34

 Disclosures: Drs Heffner, Strong, Ms Thompson, and Mr Blom have no financial disclosures to make. Dr Anthenelli provides consultant, advisory, and/or speakers' bureau services to Sanofi-Aventis and Pfizer. The Tri-State Tobacco and Alcohol Research Center receives research support from Lilly, Nabi Biopharmaceuticals, and Pfizer.

PII: S0741-8329(10)00048-0

doi: 10.1016/j.alcohol.2010.05.008

Alcohol
Volume 44, Issue 5 , Pages 401-406 , August 2010