Alcohol
Volume 44, Issue 5 , Pages 415-423 , August 2010

Distribution of ADH1B, ALDH2, CYP2E1∗6, and CYP2E1∗7B genotypes in Turkish population

Received 12 March 2010 ,Revised 4 June 2010 ,Accepted 4 June 2010.

References 

  1. Agarwal DP. Genetic polymorphisms of alcohol metabolizing enzymes. Pathol. Biol. 2001;49:703–709
  2. Ahn KS, Abdiev S, Rahimov B, Malikov Y, Bahramov S, Okada R, et al. Alcohol dehydrogenase 1B and aldehyde dehydrogenase 2 polymorphisms in Uzbekistan. Asian Pac. J. Cancer Prev. 2009;10:17–20
  3. Borràs E, Coutelle C, Rosell A, Fernández-Muixi F, Broch M, Crosas B, et al. Genetic polymorphism of alcohol dehydrogenase in europeans: the ADH2*2 allele decreases the risk for alcoholism and is associated with ADH3*1. Hepatology. 2000;31:984–989
  4. Bosron WF, Li TK, Vallee BL. New molecular forms of human liver alcohol dehydrogenase: isolation and characterization of ADH Indianapolis. Proc. Natl. Acad. Sci. U.S.A. 1980;77:5784–5788
  5. Bouchardy C, Hirvonen A, Coutelle C, Ward PJ, Dayer P, Benhamou S. Role of alcohol dehydrogenase 3 and cytochrome P-4502E1 genotypes in susceptibility to cancers of the upper aerodigestive tract. Int. J. Cancer. 2000;87:734–740
  6. Brennan P, Lewis S, Hashibe M, Bell DA, Boffetta P, Bouchardy C, et al. Pooled analysis of alcohol dehydrogenase genotypes and head and neck cancer: a HuGE review. Am. J. Epidemiol. 2004;159:1–16
  7. Caro AA, Cederbaum AI. Oxidative stress, toxicology, and pharmacology of CYP2E1. Annu. Rev. Pharmacol. Toxicol. 2004;44:27–42
  8. Cichoz-Lach H, Celiński K, Słomka M. Alcohol-metabolizing enzyme gene polymorphisms and alcohol chronic pancreatitis among Polish individuals. HPB (Oxford). 2008;10:138–143
  9. Crabb DW, Matsumoto M, Chang D, You M. Overview of the role of alcohol dehydrogenase and aldehyde dehydrogenase and their variants in the genesis of alcohol-related pathology. Proc. Nutr. Soc. 2004;63:49–63
  10. Edenberg HJ. The genetics of alcohol metabolism: role of alcohol dehydrogenase and aldehyde dehydrogenase variants. Alcohol Res. Health. 2007;30:5–13
  11. Ernstgard L, Warholm M, Johanson G. Robustness of chlorzoxazone as an in vivo measure of cytochrome P450 2E1 activity. Br. J. Clin. Pharmacol. 2004;58:190–200
  12. Fairbrother KS, Grove J, de Waziers I, Mel DT, Day CP, Crespi CL, et al. Detection and characterization of novel polymorphisms in the CYP2E1 gene. Pharmacogenetics. 1998;8:543–552
  13. Fischer M, Wetherill LF, Carr LG, You M, Crabb DW. Association of the aldehyde dehydrogenase 2 promoter polymorphism with alcohol consumption and reactions in an American Jewish population. Alcohol. Clin. Exp. Res. 2007;31:1654–1659
  14. García-Martín E, Martínez C, Serrador M, Navarro H, Navacerrada F, Agúndez JA, et al. Alcohol dehydrogenase 2 genotype and risk for migraine. Headache. 2010;50:85–91
  15. Garte S, Gaspari L, Alexandrie AK, Ambrosone C, Autrup H, Autrup JL, et al. Metabolic gene polymorphism frequencies in control populations. Cancer Epidemiol. Biomarkers Prev. 2001;10:1239–1248
  16. Gemma S, Vichi S, Testai E. Individual susceptibility and alcohol effects: biochemical and genetic aspects. Ann. Ist. Super. Sanita. 2006;42:8–16
  17. Goedde HW, Agarwal DP, Fritze G, Meier-Tackmann D, Singh S, Beckmann G, et al. Distribution of ADH2 and ALDH2 genotypes in different populations. Hum. Genet. 1992;88:344–346
  18. Gordillo-Bastidas E, Panduro A, Gordillo-Bastidas D, Zepeda-Carrillo EA, García-Bañuelos JJ, Muñoz-Valle JF, et al. Polymorphisms of alcohol metabolizing enzymes in indigenous Mexican population: unusual high frequency of CYP2E1*c2 allele. Alcohol. Clin. Exp. Res. 2010;34:142–149
  19. Guo YM, Wang Q, Liu YZ, Chen HM, Qi Z, Guo QH. Genetic polymorphisms in cytochrome P4502E1, alcohol and aldehyde dehydrogenases and the risk of esophageal squamous cell carcinoma in Gansu Chinese males. World J. Gastroenterol. 2008;14:1444–1449
  20. Hartley DP, Ruth JA, Petersen DR. The hepatocellular metabolism of 4-hydroxynonenal by alcohol dehydrogenase, aldehyde dehydrogenase, and glutathione S-transferase. Arch. Biochem. Biophys. 1995;316:197–205
  21. Hildesheim A, Anderson LM, Chen CJ, Cheng YJ, Brinton LA, Daly AK, et al. CYP2E1 genetic polymorphisms and risk of nasopharyngeal carcinoma in Taiwan. J. Natl. Cancer Inst. 1997;89:1207–1212
  22. Iron A, Groppi A, Fleury B, Begueret J, Cassaigne A, Couzigou P. Polymorphism of class I alcohol dehydrogenase in French, Vietnamese and Niger populations: genotyping by PCR amplification and RFLP analysis on dried blood spots. Ann. Genet. 1992;35:152–156
  23. Ishikawa H, Ishikawa T, Yamamotob H. Genotoxic effects of alcohol in human peripheral lymphocytes modulated by ADH1B and ALDH2 gene polymorphisms. Mutat. Res. 2007;615:134–142
  24. Kato S, Shields PG, Caporaso NE, Sugimura H, Trivers GE, Tucker MA, et al. Analysis of cytochrome P450 2E1 genetic polymorphisms in relation to human lung cancer. Cancer Epidemiol. Biomarkers Prev. 1994;3:515–518
  25. Konishi T, Calvillo M, Leng A-S, Feng J, Lee T, Lee H, et al. The ADH3*2 and CYP2E1 c2 alleles increase the risk of alcoholism in Mexican American men. Exp. Mol. Pathol. 2003;l74:183–189
  26. Lee M, Bae MA. Docosahexaenoic acid induces apoptosis in CYP2E1-containing HepG2 cells by activating the c-Jun N-terminal protein kinase related mitochondrial damage. J. Nutr. Biochem. 2007;18:348–354
  27. Lieber CS. Ethanol metabolism, cirrhosis and alcoholism. Clin. Chim. Acta. 1997;257:59–84
  28. Luczak SE, Elvine-Kreis B, Shea SH, Carr LG, Wall TL. Genetic risk for alcoholism relates to level of response to alcohol in Asian-American men and women. J. Stud. Alcohol. 2002;63:74–82
  29. Luo H, Tu G, Zhang Y. Detection of usual and uncommon aldehyde dehydrogenase alleles by mismatch amplification mutation assay. Clin. Chem. Lab. Med. 2001;39:1195–1197
  30. Macgregor S, Lind PA, Bucholz KK, Hansell NK, Madden PA, Richter MM, et al. Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis. Hum. Mol. Genet. 2009;18:580–593
  31. Matsuo K, Wakai K, Hirose K. A gene-gene interaction between ALDH2 Glu487Lys and ADH2 His47Arg polymorphisms regarding the risk of colorectal cancer in Japan. Carcinogenesis. 2006;27:1018–1023
  32. Mittal RD, Srivastava DS, Mandhani A, Mittal B. Genetic polymorphism of drug metabolizing enzymes (CYP2E1, GSTP1) and susceptibility to bladder cancer in North India. Asian Pac. J. Cancer Prev. 2005;6:6–9
  33. Mizoi Y, Yamamoto K, Ueno Y, Fukunaka S, Harada S. Involvement of genetic polymorphism of alcohol and aldehyde dehydrogenases in individual variation of alcohol metabolism. Alcohol Alcohol. 1994;29:707–710
  34. Neuhaus T, Ko Y-D, Lorenzen K, Fronhffs S, Harth V, Bröde P, et al. Association of cytochrome P450 2E1 Polymorphisms and head and neck squamous cell cancer. Toxicol. Lett. 2004;151:273–282
  35. Neumark YD, Friedlander Y, Durst R, Leitersdorf E, Jaffe D, Ramchandani VA, et al. Alcohol dehydrogenase polymorphisms influence alcohol-elimination rates in a male Jewish population. Alcohol. Clin. Exp. Res. 2004;28:10–14
  36. Omer B, Ozbek U, Akköse A, Kiliç G. Genetic polymorphism of cytochrome P450 2E1 in the Turkish population. Cell Biochem. Funct. 2001;19:273–275
  37. Quinones L, Lucas D, Godoy J, Caceres D, Berthou F, Varela N, et al. CYP1A1, CYP2E1 and GSTM1 genetic polymorphisms. The effect of single and combined genotypes on lung cancer susceptibility in Chilean people. Cancer Lett. 2001;174:35–44
  38. Rossini A, Lima SS, Rapozo DC, Faria M, Albano RM, Pinto LF. CYP2A6 and CYP2E1 polymorphisms in a Brazilian population living in Rio de Janeiro. Braz. J. Med. Biol. Res. 2006;39:195–201
  39. Shen YC, Fan JH, Edenberg HJ, Li TK, Cui YH, Wang YF, et al. Polymorphism of ADH and ALDH genes among four ethnic groups in China and effects upon the risk for alcoholism. Alcohol. Clin. Exp. Res. 1997;21:1272–1277
  40. Soya SS, Padmaja N, Adithan C. Genetic polymorphisms of CYP2E1 and GSTP1 in a South Indian population—comparison with North Indians, Caucasians and Chinese. Asian Pac. J. Cancer Prev. 2005;6:315–319
  41. Sun F, Tsuritani I, Honda R, Ma Z, Yamada Y. Association of genetic polymorphisms of alcohol-metabolizing enzymes with excessive alcohol consumption in Japanese men. Hum. Genet. 1999;105:295–300
  42. Tamakoshi A, Hamajima N, Kawase H, Wakai K, Katsuda N, Saito T, et al. Duplex polymerase chain reaction with confronting two-pair primers (PCR-CTPP) for genotyping alcohol dehydrogenase β subunit (ADH2) and aldehyde dehydrogenase 2 (ALDH2). Alcohol Alcohol. 2003;38:407–410
  43. Terelius Y, Norsten-Höög C, Cronholm T, Ingelman-Sundberg M. Acetaldehyde as a substrate for ethanol-inducible cytochrome P450 (CYP2E1). Biochem. Biophys. Res. Commun. 1991;179:689–694
  44. Ulusoy G, Arinç E, Adali O. Genotype and allele frequencies of polymorphic CYP2E1 in the Turkish population. Arch. Toxicol. 2007;81:711–718
  45. Vasiliou V, Bairoch A, Tipton KF, Nebert DW. Eukaryotic aldehyde dehydrogenase (ALDH) genes: human polymorphisms, and recommended nomenclature based on divergent evolution and chromosomal mapping. Pharmacogenetics. 1999;9:421–434
  46. Verlaan M, Te Morsche RH, Roelofs HM, Laheij RJ, Jansen JB, Peters WH, et al. Genetic polymorphisms in alcohol-metabolizing enzymes and chronic pancreatitis. Alcohol Alcohol. 2004;39:20–24
  47. Wall TL. Genetic associations of alcohol and aldehyde dehydrogenase with alcohol dependence and their mechanisms of action. Ther. Drug Monit. 2005;27:700–703
  48. Wang SM, Zhu AP, Li D, Wang Z, Zhang P, Zhang GL. Frequencies of genotypes and alleles of the functional SNPs in CYP2C19 and CYP2E1 in mainland Chinese Kazakh, Uygur and Han populations. J Hum. Genet. 2009;54:372–375
  49. Wang Y, Yang H, Li L, Wang H, Zhang C, Yin G, et al. Association between CYP2E1 genetic polymorphisms and lung cancer risk: a meta-analysis. Eur. J. Cancer. 2010;46:758–764
  50. Wu C, Wu D, Hsu H, Kao E, Lee J, Lin C, et al. Relationship between genetic polymorphisms of alcohol and aldehyde dehydrogenases and esophageal squamous cell carcinoma risk in males. World J. Gastroenterol. 2005;11:5103–5108
  51. Yang BM, O'Reilly DA, Demaine AG, Kingsnorth AN. Study of polymorphisms in the CYP2E1 gene in patients with alcoholic pancreatitis. Alcohol. 2001;23:91–97
  52. Yang H, Zhou Y, Zhou Z, Liu J, Yuan X, Matsuo K, et al. A novel polymorphism rs1329149 of CYP2E1 and a known polymorphism rs671 of ALDH2 of alcohol metabolizing enzymes are associated with colorectal cancer in a southwestern Chinese population. Cancer Epidemiol. Biomarkers Prev. 2009;18:2522–2527
  53. Yang ZN, Davis GJ, Hurley TD, Stone CL, Li TK, Bosron WF. Catalytic efficiency of human alcohol dehydrogenases for retinol oxidation and retinal reduction. Alcohol. Clin. Exp. Res. 1994;18:587–591
  54. Yokoyama A, Kato H, Yokoyama T, Tsujinaka T, Muto M, Omori T, et al. Genetic polymorphisms of alcohol and aldehyde dehydrogenases and glutathione S-transferase M1 and drinking, smoking, and diet in Japanese men with esophageal squamous cell carcinoma. Carcinogenesis. 2002;23:1851–1859

PII: S0741-8329(10)00066-2

doi: 10.1016/j.alcohol.2010.06.002

Alcohol
Volume 44, Issue 5 , Pages 415-423 , August 2010

Article Tools

* Image Usage & Resolution