Alcohol
Volume 46, Issue 1 , Pages 17-27 , February 2012

Effects of naltrexone and LY255582 on ethanol maintenance, seeking, and relapse responding by alcohol-preferring (P) rats

  • Ronnie Dhaher

      Affiliations

    • Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    • Corresponding Author InformationCorresponding author. Department of Laboratory Medicine, Yale University School of Medicine, 330 Cedar Street CB 438, New Haven, CT 06520-8035, USA. Tel.: +1-317-430-6257; fax: +1-203-785-2236.
    • ,
  • Jamie E. Toalston

      Affiliations

    • Department of Psychiatry, Institute of Psychiatric Research, Indiana School of Medicine, Indiana University, Indianapolis, IN 46202, USA
    • Department of Psychology, Purdue School of Science, Indiana University-Purdue University at Indianapolis, Indianapolis, IN 46202, USA
    • ,
  • Sheketha R. Hauser

      Affiliations

    • Department of Psychiatry, Institute of Psychiatric Research, Indiana School of Medicine, Indiana University, Indianapolis, IN 46202, USA
    • ,
  • Richard L. Bell

      Affiliations

    • Department of Psychiatry, Institute of Psychiatric Research, Indiana School of Medicine, Indiana University, Indianapolis, IN 46202, USA
    • Department of Psychology, Purdue School of Science, Indiana University-Purdue University at Indianapolis, Indianapolis, IN 46202, USA
    • ,
  • David L. McKinzie

      Affiliations

    • Neuroscience Discovery Research, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285, USA
    • ,
  • William J. McBride

      Affiliations

    • Department of Psychiatry, Institute of Psychiatric Research, Indiana School of Medicine, Indiana University, Indianapolis, IN 46202, USA
    • Department of Biochemistry, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    • ,
  • Zachary A. Rodd

      Affiliations

    • Department of Psychiatry, Institute of Psychiatric Research, Indiana School of Medicine, Indiana University, Indianapolis, IN 46202, USA
    • Department of Psychology, Purdue School of Science, Indiana University-Purdue University at Indianapolis, Indianapolis, IN 46202, USA

Received 5 November 2009 ,Revised 25 August 2011 ,Accepted 25 August 2011.

  • Image Result

    Depicts the timeline in which the rats proceed through the Pavlovian Spontaneous Recovery (PSR), relapse, and maintenance procedures.

    Depicts the timeline in which the rats proceed through the Pavlovian Spontaneous Recovery (PSR), relapse, and maintenance procedures.

  • Image Result

    Depicts the mean (±standard error of the mean) responses/session on the lever previously associated with the delivery of ethanol in alcohol-preferring (P) rats (n=8/group) given 0, 1, 5, or 10mg/kg na

    Depicts the mean (±standard error of the mean) responses/session on the lever previously associated with the delivery of ethanol in alcohol-preferring (P) rats (n=8/group) given 0, 1, 5, or 10mg/kg naltrexone (NAL) subcutaneously 30min prior to the four Pavlovian Spontaneous Recovery (PSR) session. *Indicates that saline and 1 or 5mg/kg NAL-treated rats responded significantly more on the ethanol lever during the first PSR session compared with baseline levels.

  • Image Result
    Depicts the mean (±standard error of the mean) responses/session on the ethanol lever by alcohol-preferring (P) rats (n=8/group) given 0, 1, 5, or 10mg/kg naltrexone (NAL) 30min prior to each of the i

    Depicts the mean (±standard error of the mean) responses/session on the ethanol lever by alcohol-preferring (P) rats (n=8/group) given 0, 1, 5, or 10mg/kg naltrexone (NAL) 30min prior to each of the initial four ethanol reexposure session. *Indicates that saline-treated rats responded significantly more on the ethanol lever during the first relapse session compared with baseline levels, and is significantly higher than all other groups. +Indicate that saline-treated rats responded for ethanol more than all other groups, but was not different than baseline. #Indicates that responses for all NAL doses were lower than baseline.

  • Image Result
    Depicts the mean (±standard error of the mean) responses/session on the ethanol lever by alcohol-preferring (P) rats (n=8/group) given 0, 1, 5, or 10mg/kg naltrexone (NAL) 30min during four consecutiv

    Depicts the mean (±standard error of the mean) responses/session on the ethanol lever by alcohol-preferring (P) rats (n=8/group) given 0, 1, 5, or 10mg/kg naltrexone (NAL) 30min during four consecutive maintenance test sessions. *Indicates that saline-treated rats responded significantly more on the ethanol lever than all other groups. +Indicates that saline-treated rats responded more for ethanol than did the 5, or 10mg/kg NAL-treated rats. #Indicates responses for all NAL doses were lower than baseline. aIndicates responses for the 5 and 10mg/kg doses are still lower than baseline.

  • Image Result
    Depicts the mean (±standard error of the mean) responses/session on the lever previously associated with the delivery of ethanol in alcohol-preferring (P) rats (n=8/group) given 0, 0.03, 0.1, 0.3, or

    Depicts the mean (±standard error of the mean) responses/session on the lever previously associated with the delivery of ethanol in alcohol-preferring (P) rats (n=8/group) given 0, 0.03, 0.1, 0.3, or 1mg/kg LY255582 (LY) 30min prior to each of the four Pavlovian Spontaneous Recovery (PSR) sessions. *Indicates that vehicle and 0.03mg/kg LY rats responded significantly more on the ethanol lever during the first PSR session compared with baseline levels. +Indicates that 0.1mg/kg group responded significantly more on the ethanol lever during the first PSR session compared with baseline levels.

  • Image Result
    Depicts the mean (±standard error of the mean) responses/session on the ethanol lever under relapse conditions by alcohol-preferring (P) rats (n=8/group) given 0, 0.03, 0.1, 0.3, or 1mg/kg LY255582 (L

    Depicts the mean (±standard error of the mean) responses/session on the ethanol lever under relapse conditions by alcohol-preferring (P) rats (n=8/group) given 0, 0.03, 0.1, 0.3, or 1mg/kg LY255582 (LY) 30min prior to each of the initial four reexposure sessions. *Indicates that rats administered vehicle responded significantly more on the ethanol lever during the first reinstatement session compared with baseline levels and significantly more than all LY-treated rats. +Indicates that vehicle-treated rats responded more on the ethanol lever than all LY-treated rats, but responding was different than baseline. #Indicates that vehicle-treated rats responded more than 0.1, 0.3, or 1mg/kg LY-treated rats. aIndicates that all LY were lower than baseline. bIndicates that 0.1, 0.3, and 1.0 LY doses were lower than baseline.

  • Image Result
    Depicts the mean (±standard error of the mean) responses/session on the ethanol lever under maintenance conditions by alcohol-preferring (P) rats (n=8/group) given 0, 0.03, 0.1, 0.3, or 1mg/kg LY25558

    Depicts the mean (±standard error of the mean) responses/session on the ethanol lever under maintenance conditions by alcohol-preferring (P) rats (n=8/group) given 0, 0.03, 0.1, 0.3, or 1mg/kg LY255582 (LY) 30min prior to maintenance test sessions. *Indicates that rats administered vehicle or 0.03mg/kg LY responded significantly more on the ethanol lever than other LY-treated rats. +Indicates that vehicle-treated rats responded more than all LY-treated rats, and that 0.03mg/kg LY-treated rats responded more than all other LY-treated rats. #Indicates that 0.1, 0.3, and 1.0 LY groups had lower responses than baseline.

PII: S0741-8329(11)00462-9

doi: 10.1016/j.alcohol.2011.08.011

Alcohol
Volume 46, Issue 1 , Pages 17-27 , February 2012

Article Tools

* Image Usage & Resolution