Alcohol
Volume 20, Issue 1 , Pages 31-36 , January 2000

Motor impairment produced by ethanol and site-selective NMDA receptor antagonists in mice: tolerance and cross-tolerance

  • Olga N Neznanova

      Affiliations

    • Laboratory of Behavioral Pharmacology, Department of Psychopharmacology, Institute of Pharmacology, Pavlov Medical University, Lev Tolstoy St., 6/8, 197089, St. Petersburg, Russia
  • ,
  • Elena A Blokhina

      Affiliations

    • Laboratory of Behavioral Pharmacology, Department of Psychopharmacology, Institute of Pharmacology, Pavlov Medical University, Lev Tolstoy St., 6/8, 197089, St. Petersburg, Russia
  • ,
  • Irina A Sukhotina

      Affiliations

    • Laboratory of Behavioral Pharmacology, Department of Psychopharmacology, Institute of Pharmacology, Pavlov Medical University, Lev Tolstoy St., 6/8, 197089, St. Petersburg, Russia
  • ,
  • Anton Y Bespalov

      Affiliations

    • Laboratory of Behavioral Pharmacology, Department of Psychopharmacology, Institute of Pharmacology, Pavlov Medical University, Lev Tolstoy St., 6/8, 197089, St. Petersburg, Russia
    • Corresponding Author InformationCorresponding author. Tel.: +7-1-812-238-7108; Fax: +7-1-812-346-3414.(A.Y. Bespalov)

Received 15 April 1999 ,Revised 14 June 1999 ,Accepted 20 June 1999.

References 

  1. Balster RL, Willetts J. Phencyclidine (a drug of abuse and a tool for neuroscience research). In:  Schuster CR,  Kuhar MJ editor. Pharmacological Aspects of Drug Dependence (Towards an Integrated Neurobehavioral Approach. Handbook of Experimental Pharmacology, Vol. 118). Berlin: Springer-Verlag; 1996;p. 233–262
  2. Boast CA, Pastor G, Gerhardt SC, Hall NR, Liebman JM. Behavioral tolerance and sensitization to CGS 19755, a competitive N-methyl-D-aspartate receptor antagonist. J Pharmacol Exp Ther. 1988;247:556–561
  3. Collins AC, Burch JB, de Fiebre CM, Marks MJ. Tolerance to and cross tolerance between ethanol and nicotine. Pharmacol Biochem Behav. 1988;29:365–373
  4. Colombo G, Grant KA. NMDA receptor complex antagonists have ethanol-like discriminative stimulus effects. Ann NY Acad Sci. 1992;654:421–423
  5. Commissaris RL, Rech RH. Tolerance and cross-tolerance to central nervous system depressants after chronic pentobarbital or chronic methaqualone administration. Pharmacol Biochem Behav. 1983;18:327–3311983
  6. Danysz W, Parsons CG. Glycine and NMDA receptors—physiological significance and possible therapeutic applications. Pharmacol Rev. 1998;50:597–664
  7. Danysz W, Parsons CG, Kornhuber J, Schmidt WJ, Quack G. Aminoadamantanes as NMDA receptor antagonists and antiparkinsonian agents—preclinical studies. Neurosci Biobehav Rev. 1997;21:455–468
  8. Follesa P, Ticku MK. Chronic ethanol-mediated up-regulation of the N-methyl-d-aspartate receptor polypeptide subunits in mouse cortical neurons in culture. J Biol Chem. 1996;271:13297–13299a
  9. Follesa P, Ticku MK. NMDA receptor upregulation (molecular studies in cultured mouse cortical neurons after chronic antagonist exposure). J Neurosci. 1996;16:2172–2178b
  10. Grant KA, Valverius P, Hudspith M, Tabakoff B. Ethanol withdrawal seizures and the NMDA receptor complex. Eur J Pharmacol. 1990;176:289–296
  11. Gulya K, Grant KA, Valverius P, Hoffman PL, Tabakoff B. Brain regional specificity and time-course of changes in the NMDA receptor-ionophore complex during ethanol withdrawal. Brain Res. 1991;547:129–134
  12. Henkel JG, Hane JT, Gianutsos G. Structure antiparkinson activity relationships in the aminoadamantanes. Influence of bridgehead substitution. J Med Chem. 1982;25:51–56
  13. Heresco-Levy U, Javitt DC. The role of N-methyl-D-aspartate (NMDA) receptor-mediated neurotransmission in the pathophysiology and therapeutics of psychiatric syndromes. Eur Neuropsychopharmacol. 1998;8:141–152
  14. Herrling PL, Emre M, Watkins JC. d-CPPene (SDZ EAA-494)—a competitive NMDA receptor antagonist (pharmacology and results in humans). In:  Herrling PL editors. Excitatory Amino Acids—Clinical Results with Antagonists. San Diego, CA: Academic Press; 1997;p. 7–21
  15. Hesselink MB, Smolders HG, De Boer AG, Breimer DD, Danysz W. Modifications of the behavioural profile of uncompetitive NMDA receptor antagonist, memantine, amantadine and (+)MK-801 after chronic administration. Behav Pharmacol. 1999;10:85–98
  16. Jessa M, Nazar M, Bidzinski A, Plaznik A. The effects of repeated administration of diazepam, MK-801 and CGP 37849 on rat behavior in two models of anxiety. Eur Neuropsychopharmacol. 1996;6:55–61
  17. Kim CK, Pinel JPJ, Dalal S, Kippin TE, Kalynchuk LE, Payne GJ. Contingent drug tolerance (differential tolerance to the anticonvulsant, hypothermic, and ataxic effects of ethanol). Pharmacol Biochem Behav. 1995;52:531–539
  18. Khanna JM, Le AD, Kalant H, Chau A, Shah G. Effect of lipid solubility on the development of chronic cross-tolerance between ethanol and different alcohols and barbiturates. Pharmacol Biochem Behav. 1997;57:101–110
  19. Kumar R, Stolerman IP. Experimental and clinical aspects of drug dependence. In:  Iverson LL,  Iverson SD,  Snyder SH editor. Principles of Behavioral Pharmacology, Vol. 7. New York: Plenum Press; 1977;p. 321–367
  20. Liljequist S. The competitive NMDA receptor antagonist, CGP 39551, inhibits ethanol withdrawal seizures. Eur J Pharmacol. 1991;192:197–198
  21. Lovinger D. Alcohols and neurotransmitter gated ion channels. Naunyn-Schmied Arch Pharmacol. 1997;356:267–282
  22. Lu Y, France CP, Woods JH. Tolerance to the cataleptic effect of the N-methyl-D-aspartate (NMDA) receptor antagonists in pigeons (cross-tolerance between PCP-like compounds and competitive NMDA antagonists). J Pharmacol Exp Ther. 1992;263:499–504
  23. Rabbani M, Wright EJ, Little HJ. Tolerance to competitive NMDA antagonists, but no crosstolerance with barbiturates. Pharmacol Biochem Behav. 1995;50:9–15
  24. Siemens AJ, Doyle OL. Cross-tolerance between delta9-tetrahydrocannabinol and ethanol (the role of drug disposition). Pharmacol Biochem Behav. 1979;10:49–55
  25. Skolnick P, Miller R, Young A, Boje K, Trullas R. Chronic treatment with 1-aminocyclopropanecarboxylic acid desensitizes behavioral responses to compounds acting at the N-methyl-D-aspartate receptor complex. Psychopharmacol. 1992;107:489–496
  26. Smith SE, Chapman AG. Acute and chronic anticonvulsant effects of D(-) CPPene in genetically epilepsy-prone rats. Epilepsy Res. 1993;15:193–199
  27. Snell LD, Tabakoff B, Hoffman PL. Radioligand binding to the N-methyl-d-aspartate receptor/ionophore complex (alterations by ethanol in vitro and by chronic in vivo ethanol ingestion). Brain Res. 1993;602:91–98
  28. Sprague GL, Craigmill AL. Ethanol and delta-9-tetrahydrocannabinol (mechanism for cross-tolerance in mice). Pharmacol Biochem Behav. 1976;5:409–415
  29. Trevisan L, Fitzgerald LW, Brose N, Gasic GP, Heinemann SF, Duman RS, et al. Chronic ingestion of ethanol up-regulates NMDAR1 receptor subunit immunoreactivity in rat hippocampus. J Neurochem. 1994;62:1635–1638
  30. Tsai G, Gastfrield DR, Coyle JT. The glutamatergic basis of human alcoholism. Am J Psychiatry. 1995;152:332–340
  31. Urwyler S, Campbell E, Fricker G, Jenner P, Lemaire M, McAllister KH, et al. Biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a novel class of potent competitive N-methyl-D-aspartate receptor antagonists—II. Pharmacological characterization in vivo. Neuropharmacol. 1996;35:655–669
  32. Uzbay IT, Kayaalp SO. Heterogeneity of tolerance developed to effects of ethanol on rotarod and accelerod performances in rats. Alcohol. 1995;12:593–595
  33. Van Amsterdam C, Lemaire M. Pharmacokinetic profile of SDZ EAA 494 in blood, brain and CSF using microdialysis. Eur J Pharm Sci. 1997;5:109–116
  34. Willetts J, Clissold DB, Hartman TL, Brandsgaard RR, Hamilton GS, Ferkany JW. Behavioral pharmacology of NPC 17742, a competitive N-methyl-D-aspartate (NMDA) antagonist. J Pharmacol Exp Ther. 1993;265:1055–1062
  35. Williams K, Dichter MA, Molinoff PB. Up-regulation of N-methyl-D-aspartate receptors on cultured cortical neurons after exposure to antagonists. Mol Pharmacol. 1992;42:147–151

PII: S0741-8329(99)00053-1

Alcohol
Volume 20, Issue 1 , Pages 31-36 , January 2000