Alcohol
Volume 20, Issue 1 , Pages 75-81 , January 2000

Differential sensitivity of mouse neural crest cells to ethanol-induced toxicity

  • Shao-yu Chen

      Affiliations

    • Department of Cell Biology and Anatomy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7090, USA
    • ,
  • Ammasi Periasamy

      Affiliations

    • Department of Cell Biology and Anatomy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7090, USA
    • ,
  • Bing Yang

      Affiliations

    • Department of Cell Biology and Anatomy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7090, USA
    • ,
  • Brian Herman

      Affiliations

    • Department of Cell Biology and Anatomy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7090, USA
    • ,
  • Ken Jacobson

      Affiliations

    • Department of Cell Biology and Anatomy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7090, USA
    • ,
  • Kathleen K Sulik

      Affiliations

    • Department of Cell Biology and Anatomy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7090, USA
    • Corresponding Author InformationCorresponding author. Tel.: 919-966-3208; Fax: 919-966-1856.(K.K. Sulik)

Received 20 May 1999 ,Revised 22 July 1999 ,Accepted 26 July 1999.

References 

  1. Abel EL. Pharmacology of alcohol relating to pregnancy and lactation. In:  Abel EL editors. Fetal Alcohol Syndrome and Fetal Alcohol Effects. New York: Plenum Press; 1984;p. 29–45
  2. Alexandre H, Rousseaux I, Charpentier C. Relationship between ethanol tolerance, lipid composition and plasma membrane fluidity in Saccharomyces cerevisiae and Kloeckera apiculata. FEMS Microbiol Lett. 1994;124:17–22
  3. Beauge F, Gallay J, Stibler H, Borg S. Alcohol abuse increases the lipid structural order in human erythrocyte membranes. A steady-state and time-resolved anisotropy study. Biochem Pharmacol. 1988;37:3823–3828
  4. Bertoli E, Masserini M, Sonnino S, Ghidoni R, Cestaro B, Tettamanti F. Electron paramagnetic studies on the fluidity and surface dynamics of egg phosphatidylcholine vesicles containing gangliosides. Biochim Biophys Acta. 1981;467:195–202
  5. Bianchi R, Marini P, Merlinni S. ATPase activity defects in alloxan-induced diabetic sciatic nerve recovered by ganglioside treatment. Diabetes. 1988;37:1340–1345
  6. Cartwright MM, Smith SM. Increased cell death and reduced numbers in ethanol-exposed embryos (partial basis for the fetal alcohol syndrome phenotype). Alcohol Clin Exp Res. 1995;19:378–386
  7. Chen S-Y, Yang B, Jacobson K, Sulik KK. The membrane disordering effect of ethanol on neural crest cells in vitro and the protective role of GM1 ganglioside. Alcohol. 1996;13:589–595
  8. Chen S-Y, Sulik KK. Free radicals and ethanol-induced cytotoxicity in neural crest cells. Alcohol Clin Exp Res. 1996;20:1071–1076
  9. Cherian L, Mathew J, Klemm WR. Ethanol-induced hydrolysis of brain sialoglycoconjugates in the rat (effect of sialic acid in antagonizing ethanol intoxication). Alcohol Clin Exp Res. 1989;13:435–438
  10. Dunty WC, Chen S-Y, Dehart DB, Sulik KK. Ethanol-induced apoptosis during mouse embyognesis. Dev Biol. 1999;210:237
  11. Ellis SL, Zucker RM, Dehart DB, Chen S-Y, Dunty WC, Sulik KK. Ocular apoptosis and ethanol teratogenesis. Alcohol Clin Exp Res. 1999;23(Suppl.):65
  12. Goldstein DB, Chin JH. Interaction of ethanol with biological membranes. Federation Proc. 1981;40:2073–2076
  13. Gordon G, Chazotte WB, Wang XF, Herman B. Analysis of simulated and experimental fluorescence recovery after photobleaching. Data for two diffusing components. Biophys J. 1995;68:766–778
  14. Heaton MB, Paiva M, Svanson DJ, Walker DW. Ethanol neurotoxicity in vitro (effects of GM1 ganglioside and protein synthesis inhibition). Brain Res. 1994;654:336–342
  15. Hungund BL, Reddy MV, Bharucha VA, Mahadik SP. Monosialogangliosides (GM1 and AGF2) reduce ethanol intoxication (sleep time, mortality and cerebral cortical Na+, K+-ATPase). Drug Dev Res. 1990;19:443–451
  16. Hungund BL, Mahadik SP. Role of gangliosides in behavioral and biochemical actions of alcohol (Cell membrane structure and function). Alcohol Clin Exp Res. 1993;17:329–339
  17. Hungund BL, Ross DC, Gokhale VS. Ganglioside GM1 reduces fetal alcohol effects in rat pups exposed to ethanol in utero. Alcohol Clin Exp Res. 1994;18:1248–1251a
  18. Hungund, B. L., Zheng , Z., Lin, L., & Barkai, A. I. (1994b) Ganglioside GM1 reduces ethanol induced phospholipase A2 activity in synaptosomal preparations from mice. Neurochem Int 25, 321–325.
  19. Hunter ES, Tugman JA, Sulik KK, Sadler TW. Effects of short-term exposure to ethanol on mouse embryos in vitro. Toxic Vitro. 1994;8:413–421
  20. Jacobson K, O'Dell D, Augast JT. Lateral diffusion of an 80,000-dalton glycoprotein in the plasma membrane of murine fibroblasts (relationships to cell structure and function). J Cell Biol. 1984;99:1624–1633
  21. Klemm WR, Foster DM. Alcohol in a single pharmacological dose decreases brain ganglioside. Life Sci. 1986;39:897–902
  22. Klemm, W. R., Mathew, J., & Maring, R. G. (1988). Acute alcohol decreases gangliosides in mouse brain. Alcohol 5, 215–219.
  23. Klemm WR. Dehydration (a new alcohol theory). Alcohol. 1990;7:49–59
  24. Kotch LE, Sulik KK. Experimental fetal alcohol syndrome (proposed pathogenic basis for a variety of associated craniofacial and brain anomalies). Am J Med Genet. 1992;44:168–176
  25. Kotch LE, Chen S-Y, Sulik KK. Ethanol-induced teratogenesis (free radical damage as a possible mechanism). Teratol. 1995;52:128–136
  26. Laev H, Mahadik SP, Bonheur JL, Hernandex N, Karpiak SE. GM1 ganglioside reduces glutamate toxicity to cortical cells (lowered LDH release and preserved membrane integrity). Mol Chem Neuropath. 1993;20:229–243
  27. Laev H, Karpiak SE, Gokhale VS, Hungund BL. In utero ethanol exposure retards growth and alters morphology of cortical cultures (GM1 reverses effects). Alcohol Clin Exp Res. 1995;19:1226–1233
  28. Lockett S, Jacobson JK, &Herman B. Application of 3D digital deconvolution to optically sectioned images for improving the automatic analysis of fluorescent labeled tumor specimens. SPIE-Biomed Image Process Three Dimen Microsc. 1992;1660:130–139
  29. Manev H, Favaron M, Guidotti A, Costa E. Delayed increases of Ca 2+ influx elicited by glutamate (role in the neuronal death). Mol Pharmacol. 1989;36:106–112
  30. Morgan SJ, Darling DC. Animal Cell Culture. London: BIOS Scientific in Association with the Biochemical Society; 1993;
  31. Periasamy A, Herman B. Computerized fluorescence microscopic vision in the biomedical sciences. J Computer-Assisted Microsc. 1994;6:1–26
  32. Siadat-Pajouh M, Periasamy A, Ayscue AH, Moscicki AB, Palefsky JB, Walton L, et al. Detection of human papillomavirus type 16/18 DNA in cervicovaginal cells by fluorescence based in situ hybridization and automated image cyotmetry. Cytometry. 1994;15:245–257
  33. Webster WS. Alcohol as a teratogen (a teratological perspective of the fetal alcohol syndrome). In:  Crow KE,  Batt RS editor. Human Metabolism of Alcohol. Boca Raton, FL: CRC Press; 1989;p. 134–155
  34. Yamada S, Lieber CS. Decrease in microviscosity and cholesterol content of rat liver plasma membranes after chronic ethanol feeding. J Clin Invest. 1984;74:2285–2289

PII: S0741-8329(99)00058-0

Alcohol
Volume 20, Issue 1 , Pages 75-81 , January 2000

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