Alcohol
Volume 20, Issue 1 , Pages 69-74 , January 2000

Anxiety in mice following acute aspartame and ethanol exposure

  • Christopher J LaBuda

      Affiliations

    • Department of Psychology, Shippensburg University of Pennsylvania, Shippensburg, PA 17257, USA
    • Corresponding Author InformationCorresponding author. Tel.: 817-272-5057; Fax: 817-272-2364.(C.J. LaBuda)
    • ,
  • Robert L Hale

      Affiliations

    • Department of Psychology, Shippensburg University of Pennsylvania, Shippensburg, PA 17257, USA

Received 14 May 1999 ,Revised 16 July 1999 ,Accepted 20 July 1999.

References 

  1. Cain DP, Boon F, Bevan M. Failure of aspartame to affectseizure susceptibility in kindled rats. Neuropharmacol. 1989;28:433–435
  2. Coulombe RA, Sharma RP. Neurobiochemical altercations induced by the artificial sweetener aspartame (Nutrasweet). Toxic Appl Pharmac. 1986;83:79–85
  3. Dalvi A, Rodgers RJ. GABAergic influences on plus-maze behavior in mice. Psychopharmacol (Berl). 1996;128:380–397
  4. Durcan MJ, Lister RG. Time course of ethanol's effects on locomotor activity, exploration and anxiety in mice. Psychopharmacol (Berl). 1988;96:67–72
  5. Feldman RS, Meyer JS, Quenzer LF. Principles of Neuropsychopharmacology. Sunderland, MA: Sinauer Associates, Inc; 1997;
  6. Food and Drug Administration (July 24, 1981). Docket No. 75F-0355.
  7. Hjelle JJ, Dudley RE, Marietta MP, Sanders PG, Dickie BC, Brisson J, et al. Plasma concentrations and pharmacokinetics of phenylalanine in rats and mice administered aspartame. Pharmacol. 1992;44:48–60
  8. Janssen PJCM, van der Heijden CA. Aspartame (review of recent experimental and observational data). Toxicol. 1988;50:1–26
  9. Linnoila M, Eckardt M, Durcan M, Lister R, Martin P. Interactions of serotonin with ethanol (clinical and animal studies). Psychopharm Bull. 1987;23:452–457
  10. Lipton RB, Newman LC, Cohen JS, Solomon S. Aspartame as a dietary trigger of headache. Headache. 1989;29:90–92
  11. Lister RG. The use of a plus-maze to measure anxiety in the mouse. Psychopharmacol (Berl). 1987;92:180–185
  12. Lovinger DM. Serotonin's role in alcohol's effects on the brain. Alcohol Health Res World. 1997;21:114–120
  13. Maher TJ. Neurotoxicology of food additives. Neurotoxicol. 1986;7:183–196
  14. Maher TJ, Wurtman RJ. Possible neurological effects of aspartame, a widely used food additive. Environ Health Perspect. 1987;75:53–57
  15. Moser RH. Aspartame and memory loss. JAMA. 1994;272:1543
  16. Ortiz J, Fitzgerald LW, Charlton M, Lane S, Trevisan L, Guitart X, et al. Biochemical actions of chronic ethanol exposure in the mesolimbic dopamine system. Synapse. 1995;21:289–298
  17. Pan-Hou H, Suda Y, Ohe Y, Sumi M, Yoshioka M. Effect of aspartame on N-methyl-D-aspartate-sensitive L-[3H] glutamate binding sites in rat brain synaptic membranes. Brain Res. 1990;520:351–353
  18. Pinto, J. M. B.,& Maher, T. J. (1988). Administration of aspartame potentiates pentylenetetrazole- and fluorothyl- induced seizures in mice. Neuropharmacol 27:51–55.
  19. Reilly, M. A., Debler, E. A., Fleischer, A., & Lajtha, A. (1989). Chronic aspartame ingestion does not alter cerebral levels of aminergic neurotransmitters and related amino acids in the rat brain. Res Commun Psychol Psychiat Behav 14:287–303.
  20. Roberts HJ. Reactions attributed to aspartame-containing products (551 cases). J Appl Nut. 1987;40:85–94
  21. Sepulveda C, Bustos G, Gysling K, Seguel M, Labarca R. Effects of in vitro ethanol and chronic ethanol consumption on the release of excitatory amino acids in the rat hippocampus. Brain Res. 1995;674:104–106
  22. Sharma RP, Coulombe RA. Effects of repeated doses of aspartame on serotonin and its metabolite in various regions of the mouse brain. Neurochem Toxicol. 1987;25:565–568
  23. Stokes AF, Belger A, Banich MT, Bernadine E. Effects of alcohol and chronic aspartame ingestion upon performance in aviation relevant cognitive tasks. Aviat Space Environ Med. 1994;65:7–15
  24. Stokes, A. F., Belger, A., Banich, M. T., & Taylor, H. (1991). Effects of acute aspartame and acute alcohol ingestion upon the cognitive performance of pilots. Aviat. Space Environ Med. 62: 648–653.
  25. Valenzula CF. Alcohol and neurotransmitter interactions. Alcohol Health Res World. 1997;21:144–148
  26. Vitulli, W. F., McAleer, J. E., Rockwell, A. C., Granade, C., Parman, D. L., Benoit, C., & Quinn, J. M. (1996). Aspartame's effects on behavioral thermoregulation in albino rats. Percept Mot Skills 83:15–20.
  27. Wiley JL, Cristello AF, Balster RL. Effects of site-selective NMDA receptor antagonists in an elevated plus-maze model of anxiety in mice. Eur J Pharmacol. 1995;294:101–107
  28. Wolraich ML, Lindgren SD, Stumbo PJ, Stegink LD, Applebaum MI, Kiritsy MC. Effects of diets high in sucrose or aspartame on the behavior and cognitive performance of children. New Engl J Med. 1994;330:301–307
  29. Yokogoshi H, Roberts CH, Caballero B, Wurtman RJ. Effects of aspartame and glucose administration on brain and plasma levels of large neutral amino acids and brain 5-hydrotoxins. Am J Clin Nutr. 1984;40:1–7

PII: S0741-8329(99)00060-9

Alcohol
Volume 20, Issue 1 , Pages 69-74 , January 2000

Article Tools

* Image Usage & Resolution