Alcohol
Volume 20, Issue 1 , Pages 87-91 , January 2000

Thyrotropin releasing hormone decreases alcohol intake and preference in rats

  • Paul J Kulkosky

      Affiliations

    • Department of Psychology, University of Southern Colorado, Pueblo, CO 81001-4901, USA
    • Corresponding Author InformationCorresponding author. Tel.: 719-549-2103; Fax: 719-549-2705.(P.J. Kulkosky)
  • ,
  • Clint T Allison

      Affiliations

    • Department of Psychology, University of Southern Colorado, Pueblo, CO 81001-4901, USA
  • ,
  • Brandi J Mattson

      Affiliations

    • Department of Psychology, University of Southern Colorado, Pueblo, CO 81001-4901, USA

Received 13 May 1999 ,Revised 12 July 1999 ,Accepted 2 August 1999.

References 

  1. Beleslin DB, Jovanovic-Micic D, Samardzic R, Terzic B. Studies of thyrotropin-releasing hormone (TRH)-induced defecation in cats. Pharmacol Biochem Behav. 1987;26:639–641
  2. Benicky J, Greer MA, Strbak V. Hyposmolar medium and ethanol in isosmotic solution induce the release of thyrotropin-releasing hormone (TRH) by isolated rat pancreatic islets. Life Sci. 1997;60:865–872
  3. French TA, Masserano JM, Weiner N. Influence of thyrotropin-releasing hormone and catecholamingeric interactions on CNS ethanol sensitivity. Alcohol Clin Exp Res. 1993;17:99–106
  4. Gibbs J, Fauser DJ. Bombesin works at both ends. Soc Neurosci Abst. 1981;7:380
  5. Hillbom ME. Thyroid state and voluntary alcohol consumption of albino rats. Acta Pharmacol Toxicol. 1971;29:95–105
  6. Holmes GM, Rogers RC, Bresnahan JC, Beattie MS. Thyrotropin-releasing hormone (TRH) and CNS regulation of anorectal motility in the rat. J Autonom Nerv Sys. 1995;56:8–14
  7. Kow L-M, Pfaff DW. Neuropeptides TRH and cyclo(His-Pro) share neuromodulatory but not stimulatory, action on hypothalamic neurons in vitro (implication for the regulation of feeding). Exp Brain Res. 1987;67:93–99
  8. Kulkosky PJ. Satiation of alcohol intake. In:  Smith GP editors. Satiation (From Gut to Brain). New York: Oxford; 1998;p. 263–286
  9. Li WI, Chen CL, Tiller AA, Kunkle GA. Effects of thyrotropin-releasing hormone on serum concentrations of thyroxine and triiodothyronine in healthy, thyroidectomized, thyroxine-treated, and propylthiouracil-treated dogs. Am J Vet Res. 1986;47:163–169
  10. Mason GA, Rezvani AH, Grady DR, Garbutt JC. The subchronic effects of the TRH analog TA-0910 and bromocriptine on alcohol preference in alcohol-preferring rats (development of tolerance and cross-tolerance). Alcohol Clin Exp Res. 1994;18:1196–1201
  11. Mason GA, Rezvani AH, Overstreet DH, Garbutt JC. Thyrotropin-releasing hormone analog TA-0910 reduces voluntary alcohol intake of P rats subchronically in a limited scheduled access paradigm. Alcohol Clin Exp Res. 1996;20:1000–1003
  12. Mason GA, Rezvani AH, Overstreet DH, Hamedi M, Walker CH, Yang Y, et al. Involvement of dopamine D2 receptors in the suppressive effect of the thyrotropin-releasing hormone analog TA-0910 on alcohol intake in alcohol-preferring rats. Alcohol Clin Exp Res. 1997;21:1623–1629
  13. McCown TJ, Breese GR. The interactions of thyrotropin-releasing hormone with ethanol. In:  Deitrich RA,  Erwin VG editor. Pharmacological Effects of Ethanol on the Nervous System. Boca Raton, FL: CRC Press; 1996;p. 195–202
  14. Morley JE. Neuropeptide regulation of appetite and weight. Endocrine Rev. 1987;8:256–287
  15. Morley JE, Levine AS. Thyrotropin releasing hormone (TRH) suppresses stress induced eating. Life Sci. 1980;27:269–274
  16. Morley JE, Levine AS, Kneip J, Grace M. The effect of vagotomy on the satiety effects of neuropeptides and naloxone. Life Sci. 1982;30:1943–1947
  17. Morley JE, Levine AS, Prasad C. Histidyl-proline diketopiperazine decreases food intake in rats. Brain Res. 1981;210:475–478
  18. Morzorati S, Kubek MJ. Septal TRH in alcohol-naive P and NP rats and following alcohol challenge. Brain Res Bull. 1993;31:301–304a
  19. Morzorati S, Kubek MJ. The effect of TRH on ethanol-induced sedation in alcohol-preferring and -nonpreferring rats. Neuropeptides. 1993;25:283–287b
  20. Myers RD, Metcalf G, Rice JC. Identification by microinjection of TRH-sensitive sites in the cat's brain stem that mediate respiratory, temperature and other autonomic changes. Brain Res. 1977;126:105–115
  21. Nikodemova M, Weismann P, Filipcik P, Mraz P, Greer MA, Strbak V. Both iso- and hyperosmotic ethanol stimulate release of hypothalamic thyrotropin-releasing hormone despite opposite effect on neuron volume. Neurosci. 1997;80:1263–1269
  22. Noonan LR, Walker CH, Li L, Garbutt JC, Prange AJ, Mason GA. Effects of thyroid state on preference for and sensitivity to ethanol in Fischer-344 rats. Prog Neuro-Psychopharm Biol Psychiat. 1993;17:475–486
  23. Rezvani AH, Garbutt JC, Shimoda K, Garges PL, Janowsky DS, Mason GA. Attenuation of alcohol preference in alcohol-preferring rats by a novel TRH analogue, TA-0910. Alcohol Clin Exp Res. 1992;16:326–330
  24. Rezvani A, Mason G. TRH analog TA-0910. Alternatives to naltrexone in animal models. Alcohol Clin Exp Res. 1996;20(Suppl. 8):232A–233A[roundtable]
  25. Rezvani AH, Garbutt JC, Overstreet DH, Li L, Walker CH, Yang Y, et al. Thyrotropin-releasing hormone analog TA-0910 suppresses alcohol intake in alcohol drinking African green monkeys. Alcohol Clin Exp Res. 1997;21:261–266
  26. Richter CP. Decreased appetite for alcohol and alcoholic beverages produced in rats by thyroid treatment. In:  Hoagland H editors. Hormones, Brain Function, and Behavior. New York: Academic Press; 1957;p. 217–220a
  27. Richter CP. Production and control of alcoholic cravings in rats. In:  Abramson HA editors. Neuropharmacology. New York: Josiah Macy Jr. Foundation; 1957;p. 39–146b
  28. Smith GP, Gibbs J. The satiating effects of cholecystokinin and bombesin-like peptides. In:  Smith GP editors. Satiation (From Gut to Brain). New York: Oxford; 1998;p. 97–125
  29. Vijayan E, McCann SM. Suppression of feeding and drinking activity in rats following intraventricular injection of thyrotropin releasing hormone (TRH). Endocrinol. 1977;100:1727–1730
  30. Vogel RA, Cooper BR, Barlow TS, Prange AJ, Mueller RA, Breese GR. Effects of thyrotropin-releasing hormone on locomotor activity, operant performance and ingestive behavior. J Pharmacol Exp Ther. 1979;208:161–168
  31. Witkin JM, Sickle J, Barrett JE. Potentiation of the behavioral effects of pentobarbital, chlordiazepoxide and ethanol by thyrotropin-releasing hormone. Peptides. 1984;5:809–813

PII: S0741-8329(99)00061-0

Alcohol
Volume 20, Issue 1 , Pages 87-91 , January 2000