Alcohol
Volume 20, Issue 3 , Pages 223-225 , April 2000

Safety and tolerability of gamma-hydroxybutyric acid in the treatment of alcohol-dependent patients

Received 4 May 1998 ,Revised 9 October 1998 ,Accepted 22 October 1998.

References 

  1. Addolorato G, Castelli E, Stefanini GF, Casella G, Caputo F, Marsigli L, et al. GHB Study Group (an open multicentric study evaluating 4-hydroxybutyric acid sodium salt in the medium term treatment of 179 alcohol dependent subjects). Alcohol Alcohol. 1996;31:341–345
  2. Addolorato G, Cibin M, Capristo E, Beghè F, Gessa GL, Stefanini GF, et al. Maintaining abstinence from alcohol with γ-hydroxybutyric acid. Lancet. 1998;351:38
  3. Avanzi M, Bonomini M, Federici F, Spotti R, Bonfà F. Utilità dell'associazione GHB e disulfiram nel trattamento della dipendenza da alcool. Alcologia. 1996;8(suppl. 2):73
  4. Ceccanti M, Attilia ML, Blum K, Cavaleri G, Franzese A, Sasso GF, et al. Gamma-hydroxybutyric acid versus benzodiazepines (a clinical study in chronic alcoholics). Acta Toxicol Ther. 1995;16:231–242
  5. Ceccanti M, Attilia ML, Ceccanti B, Sebastiani G, Cavaleri G, Devito R, et al. Efficacia di vari protocolli terapeutici nel trattamento della sindrome da astinenza alcolica (SSA). Alcologia. 1996;8(suppl. 2):72
  6. Centers for Disease Control . Multistate outbrake of poisonings associated with illicit use of gamma hydroxybutyrate. J Am Med Ass. 1991;265:447–448
  7. Cibin M, Zavan V. GHB e trattamento multimodale dell'alcoldipendenza (un'esperienza clinica). Alcologia. 1995;7(suppl. 2):43
  8. Chin MY, Kreutzer RA, Dyer JE. Acute poisoning from γ-hydroxybutyrate in California. West J Med. 1992;156:380–384
  9. Di Bello MG, Gambassi F, Mugnai L, Masini E, Mannaioni PF. Gamma-hydroxybutyric acid induced suppression and prevention of alcohol withdrawal syndrome and relief of craving in alcohol dependent patients. Alcologia. 1995;7:9–16
  10. Dyer JE. γ-hydroxybutyrate (a health-food product producing coma and seizure like activity). Am J Emerg Med. 1991;9:321–324
  11. Fattore L, Martellotta MC, Cossu G, Fratta W. Gamma-hydroxybutyrate (an evaluation of its rewarding properties in rats and mice). Alcohol. 2000;20:247–256
  12. Ferrara SD, Tedeschi L, Frison G, Rossi A. Fatality due to gamma-hydroxybutyric acid (GHB) and heroin intoxication. J Forensic Sci. 1995;40:501–504
  13. Food and Drug Administration . Warning about GHB. J Am Med Ass. 1991;265:1802
  14. Friedman J, Wstlake R, Furnam M. “Grevious bodily harm” (gamma hydroxybutyrate abuse leading to a Wernicke-Korsakoff syndrome). Neurology. 1996;46:469–471
  15. Gallimberti L, Canton G, Gentile N, Ferri M, Cibin M, Ferrara SD, et al. Gamma-hydroxybutyric acid for treatment of alcohol withdrawal syndrome. Lancet. 1989;2:787–789
  16. Gallimberti L, Ferri M, Ferrara SD, Fadda F, Gessa GL. Gamma-hydroxybutyric acid in the treatment of alcohol dependence (a double-blind study). Alcoholism Clin Exp Res. 1992;16:673–676
  17. Galloway GP, Frederick SL, Staggers F. Physical dependence on sodium oxybate. Lancet. 1994;343:51
  18. Galloway GP, Frederick SL, Staggers F, Gonzales M, Stalcup SA, Smith DE. Gamma-hydroxybutyrate (an emerging drug of abuse that causes physical dependence). Addiction. 1997;92:89–96
  19. Gessa GL, Agabio R, Carai MAM, Lobina C, Pani M, Reali R, et al. Mechanism of the anti-alcohol effect of gamma-hydroxybutyric acid (GHB). Alcohol. 2000;20:271–276
  20. Krawczeniuk A. The occurrence of gamma hydroxybutyric acid (GHB) in a steroid seizure. Microgram. 1993;26:160–166
  21. Luby S, Jones J, Zalewski A. GHB use in South Carolina. Am J Publ Health. 1992;82:128
  22. Maitre M. The γ-hydroxybutyrate signaling system in brain (organization and functional implications). Prog Neurobiol. 1997;51:337–361
  23. Manzato E, Cantiero D, Faccini M. Il GHB nel trattamento della dipendenza alcolica in pazienti ambulatoriali. Alcologia. 1995;7(suppl. 2):59
  24. Marwick C. Coma-inducing drug GHB may be reclassified. J Am Med Ass. 1997;277:1505–1506
  25. Montesano F, Montesano S, Mellace V, Battaglia E. L'uso razionale dell'acido gammaidrossibutirrico (GHB) nei soggetti alcolisti secondo la nostra esperienza. Alcologia. 1997;9(suppl. 2):73
  26. Mosti A, Zurla R. L'acido 4-idrossibutirrico (GHB) nella pratica clinica territoriale (analisi preliminare di 100 casi). Alcologia. 1995;7(suppl. 2):63
  27. Nimmerrichter AA, Beckmann E, Gazso E, Mader R, Marx B, Plech A, et al. Double blind controlled trial of GHB in two dosages and chlormethiazole in the treatment of alcohol withdrawal syndrome. Alcohol Alcohol. 1997;32:415
  28. Stell IM, Ryan JM. γ-hydroxybutyrate is a new recreational drug that may lead to loss of consciousness. Br Med J. 1996;313:424
  29. Stephens BG, Baselt RC. Driving under the influence of GHB?. J Anal Toxicol. 1994;18:357–358
  30. Strepparola G, Alietti M, Mascherpa M, Galimberti G, Tosi M, Lucchini A, et al. E' possibile il trattamento del craving? La nostra esperienza con l'acido gamma-idrossibutirrico. Alcologia. 1995;7(suppl. 2):73
  31. Vendramin A, Bertuola C. Contributo del GHB da solo o in associazione con SSRI nel trattamento dell'alcolismo correlato a disturbi psicopatologici. Alcologia. 1995;7(suppl. 2):75
  32. Zolesi O, Daini L, Capone MR, Aglietti M, Raimondi F, Maremmani I. The use of GHB in anticraving therapy. Preliminary experimental data of its use in alcohol and heroin dependence. In:  Tagliamonte A,  Maremmani I editor. Drug Addiction and Related Clinical Problems. Vienna, New York: Springer-Verlag; 1995;p. 57–62

PII: S0741-8329(99)00085-3

Alcohol
Volume 20, Issue 3 , Pages 223-225 , April 2000