Alcohol
Volume 21, Issue 1 , Pages 49-57 , May 2000

Effect of neonatal ethanol exposure on parvalbumin-expressing GABAergic neurons of the rat medial septum and cingulate cortex

  • J.Jean Mitchell

      Affiliations

    • University of Florida Brain Institute, University of Florida College of Medicine, Box 100244, Gainesville, FL 32610-0244, USA
    • Department of Neuroscience, University of Florida College of Medicine, Box 100244, Gainesville, FL 32610-0244, USA
    • Center for Alcohol Research, University of Florida College of Medicine, Box 100244, Gainesville, FL 32610-0244, USA
    • ,
  • Michael Paiva

      Affiliations

    • University of Florida Brain Institute, University of Florida College of Medicine, Box 100244, Gainesville, FL 32610-0244, USA
    • Department of Neuroscience, University of Florida College of Medicine, Box 100244, Gainesville, FL 32610-0244, USA
    • Center for Alcohol Research, University of Florida College of Medicine, Box 100244, Gainesville, FL 32610-0244, USA
    • ,
  • Marieta Barrow Heaton

      Affiliations

    • University of Florida Brain Institute, University of Florida College of Medicine, Box 100244, Gainesville, FL 32610-0244, USA
    • Department of Neuroscience, University of Florida College of Medicine, Box 100244, Gainesville, FL 32610-0244, USA
    • Center for Alcohol Research, University of Florida College of Medicine, Box 100244, Gainesville, FL 32610-0244, USA
    • Corresponding Author InformationCorresponding author. Department of Neuroscience, University of Florida College of Medicine, Box 100244, Gainesville, FL 32610-0244, USA. Tel.: +1-352-392-1185; fax: +1-352-392-8347

Received 1 October 1999 ,Revised 10 December 1999 ,Accepted 12 December 1999.

References 

  1. Abercrombie M. Estimation of nuclear population from microtome sections. Anat Rec. 1946;94:239–247
  2. Alcantara S, Ferrer I, Soriano E. Postnatal development of parvalbumin and calbindin D28K immunoreactivities in the cerebral cortex of the rat. Anat Embryol (Berlin). 1993;188:63–73
  3. Barnes DE, Walker DW. Prenatal ethanol exposure permanently reduces the number of pyramidal neurons in rat hippocampus. Dev Brain Res. 1981;1:333–340
  4. Bauer-Moffett C, Altman J. Ethanol-induced reductions in cerebellar growth of infant rats. Exp Neurol. 1975;48:378–382
  5. Bauer-Moffett C, Altman J. The effect of ethanol chronically administered to preweanling rats on cerebellar development: a morphological study. Brain Res. 1977;119:249–268
  6. Blanchard BA, Riley EP, Hannigan JH. Deficits on a spatial navigation task following prenatal exposure to ethanol. Neurotoxicol Teratol. 1987;9:253–258
  7. Bradley DB, Beaman FD, Moore DB, Kidd K, Heaton MB. Neurotrophic factors BDNF and GDNF protect embryonic chick spinal cord motoneurons from ethanol neurotoxicity in vivo. Dev Brain Res. 1999;112:99–106
  8. Burrows RC, Shetty AK, Phillips DE. Effects of prenatal alcohol exposure on the postnatal morphology of the rat oculomotor nucleus. Teratology. 1995;51:318–328
  9. Cheng KC, Lee J, Khanna M, Qin KN. Distribution and ontogeny of 3 alpha-hydroxysteroid dehydrogenase in the rat brain. J Steroid Biochem Mol Biol. 1994;50:85–89
  10. Clausing P, Ferguson SA, Holson RR, Allen RR, Paule MG. Prenatal ethanol exposure in rats: long-lasting effects on learning. Neurotoxicol Teratol. 1995;17:545–552
  11. Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, et al. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell. 1997;91:231–241
  12. Davies DL, Smith DE. A Golgi study of mouse hippocampal CA1 pyramidal neurons following perinatal ethanol exposure. Neurosci Lett. 1981;26:49–54
  13. de-Lecea L, del-Rio JA, Soriano E. Developmental expression of parvalbumin mRNA in the cerebral cortex and hippocampus of the rat. Mol Brain Res. 1995;32:1–13
  14. Dutar P, Bassant MH, Senut MC, Lamour Y. The septohippocampal pathway: structure and function of a central cholinergic system. Physiol Rev. 1995;75:393–427
  15. Freund TF. GABAergic septohippocampal neurons contain parvalbumin. Brain Res. 1989;478:375–381
  16. Freund TF, Antal M. GABA-containing neurons in the septum control inhibitory interneurons in the hippocampus. Nature. 1988;336:170–173
  17. Goodlett CR, Eilers AT. Alcohol-induced Purkinje cell loss with a single binge exposure in neonatal rats: a stereological study of temporal windows of vulnerability. Alcohol Clin Exp Res. 1997;21:738–744
  18. Goodlett CR, Marcussen BL, West JR. A single day of alcohol exposure during the brain growth spurt induces brain weight restriction and cerebellar Purkinje cell loss. Alcohol. 1990;7:107–114
  19. Greenberg DA, Chan J. Ethanol, calcium channels, and intracellular calcium in cultured neural cells. In:  Watson RR editors. Alcohol and Neurobiology. Boca Raton, FL: CRC Press; 1992;p. 141–160
  20. Hagg T, Van der Zee CEEM, Ross GM, Riopelle RJ. Basal forebrain neuronal loss in mice lacking neurotrophin receptor p75 —technical comment, response. Science. 1997;277:838–839
  21. Heaton MB, Mitchell JJ, Paiva M. Ethanol-induced alterations in neurotrophin expression in developing cerebellum: relationship to periods of temporal susceptibility. Alcohol Clin Exp Res. 1999;23:1637–1642
  22. Heaton MB, Moore DB, Paiva M, Gibbs T, Bernard O. Bcl-2 overexpression protects the neonatal cerebellum from ethanol neurotoxicity. Brain Res. 1999;817:13–18
  23. Heaton MB, Paiva M, Swanson DJ, Walker DW. Modulation of ethanol neurotoxicity by nerve growth factor. Brain Res. 1993;620:78–85
  24. Heaton MB, Paiva M, Swanson DJ, Walker DW. Responsiveness of cultured septal and hippocampal neurons to ethanol and neurotrophic substances. J Neurosci Res. 1994;39:305–318
  25. Heaton MB, Paiva M, Swanson DJ, Walker DW. Alterations in responsiveness to ethanol and neurotrophic substances in fetal septohippocampal neurons following chronic prenatal ethanol exposure. Dev Brain Res. 1995;85:1–13
  26. Katoh S, Mitsui Y, Kitani K, Suzuki T. Nerve growth factor rescues PC12 cells from apoptosis by increasing amount of bcl-2. Biochem Biophys Res Commun. 1996;229:653–657
  27. Katoh S, Mitsui Y, Kitani K, Suzuki T. The rescuing effect of nerve growth factor is the result of up-regulation of bcl-2 in hyperoxia-induced apoptosis of a subclone of pheochromocytoma cells, PC12h. Neurosci Lett. 1997;232:71–74
  28. Kiss J, Patel AJ. Development of cholinergic fibres innervating the cerebral cortex of the rat. Int J Dev Neurosci. 1992;10:153–170
  29. Krzywkowski P, De B-F, Senut MC, Lamour Y. Age-related changes in parvalbumin- and GABA-immunoreactive cells in the rat septum. Neurobiol Aging. 1995;16:29–40
  30. Kupferman I. Hypothalamus and limbic system: peptidergic neurons, homeostasis, and emotional behavior. In:  Kandel ER,  Schwartz JH,  Jessell TM editor. Principles of Neural Science. 3rd edn.. New York: Elsevier; 1991;p. 735–760
  31. Lauder JM, Han VK, Henderson P, Verdoorn T, Towle AC. Prenatal ontogeny of the GABAergic system in the rat brain: an immunocytochemical study. Neuroscience. 1986;19:465–493
  32. Lindvall O, Kokaia Z, Bengzon J, Elmer E, Kokaia M. Neurotrophins and brain insults. Trends Neurosci. 1994;17:490–496
  33. Luo J, West JR, Pantazis NJ. Nerve growth factor and basic fibroblast growth factor protect cerebellar granule cells in culture against ethanol-induced cell death. Alcohol Clin Exp Res. 1997;6:1108–1120
  34. McAlhany RE, West JR, Miranda RC. Glial-derived neurotrophic factor rescues calbindin-D28k-immunoreactive neurons in alcohol-treated cerebellar explant cultures. J Neurobiol. 1997;33:835–847
  35. Michel RP, Cruz O-LM. Application of the Cavalieri principle and vertical sections method to lung estimation of volume and pleural surface area. J Microsc. 1988;150:117–136
  36. Miettinen R, Sirvio J, Riekkinen P, Laasko MP, Riekkinen M, Riekkinen P. Neocortical, hippocampal and septal parvalbumin- and somatostatin-containing neurons in young and aged rats: correlation with passive avoidance and water maze performance. Neuroscience. 1993;53:367–378
  37. Miller MW. Effects of alcohol on the generation and migration of cerebral cortical neurons. Science. 1986;233:1308–1311
  38. Miller MW. Effect of prenatal exposure to ethanol on the development of the cerebral cortex: neuronal generation. Alcohol Clin Exp Res. 1988;12:440–449
  39. Miller MW. Generation of neurons in the rat dentate gyrus and hippocampus: effects of prenatal or postnatal treatment with ethanol. Alcohol Clin Exp Res. 1995;19:1500–1509
  40. Mitchell JJ, Paiva M, Moore DB, Walker DW, Heaton MB. A comparative study of ethanol, hypoglycemia, hypoxia and neurotrophic factor interactions with fetal hippocampal neurons: a multi-factor in vitro model for developmental ethanol effects. Dev Brain Res. 1998;105:241–250
  41. Mitchell JJ, Paiva M, Walker DW, Heaton MB. BDNF and NGF afford in vitro neuroprotection against ethanol combined with acute ischemia and chronic hypoglycemia. Dev Neurosci. 1999;21:68–75
  42. Mocchetti I, Wrathall JR. Neurotrophic factors in central nervous system trauma. J Neurotrauma. 1995;12:853–870
  43. Moore DB, Lee P, Paiva M, Walker DW, Heaton MB. Effects of neonatal ethanol exposure on cholinergic neurons of the rat medial septum. Alcohol. 1998;15:219–226
  44. Moore DB, Quintero MA, Ruygrok AC, Walker DW, Heaton MB. Prenatal ethanol exposure reduces parvalbumin-immunoreactive GABAergic neuronal number in the adult rat cingulate cortex. Neurosci Lett. 1998;249:25–28
  45. Moore DB, Ruygrok AC, Walker DW, Heaton MB. Effects of prenatal ethanol exposure on parvalbumin-expressing GABAergic neurons in the adult rat medial septum. Alcohol Clin Exp Res. 1997;21:849–856
  46. Moore DB, Walker DB, Heaton MB. Neonatal ethanol exposure alters bcl-2 family mRNA levels in the rat cerebellar vermis. Alcohol Clin Exp Res. 1999;23:1251–1261
  47. Muir JL, Everitt BJ, Robbins TW. The cerebral cortex of the rat and visual attentional function dissociable effects of mediofrontal, cingulate, anterior dorsolateral, and parietal cortex lesions on a five-choice serial reaction task. Cereb Cortex. 1996;6:470–481
  48. Muller Y, Tangre K, Clos J. Autocrine regulation of apoptosis and Bcl-2 expression by nerve growth factor in early differentiating cerebellar granule neurons involves low affinity neurotrophin receptor. Neurochem Int. 1997;31:177–191
  49. Pal N, Alkana RL. Use of inhalation to study the effect of ethanol and ethanol dependence on neonatal mouse development without maternal separation: a preliminary study. Life Sci. 1997;61:1269–1281
  50. Paus T, Petrides M, Evans AC, Meyer E. Role of the human anterior cingulate cortex in the control of oculomotor, manual, and speech responses: a positron emission tomography study. J Neurophysiol. 1993;70:453–469
  51. Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates. New York: Academic Press; 1982;
  52. Peterson DA, Leppert JT, Lee KF, Gage FH. Basal forebrain neuronal loss in mice lacking neurotrophin receptor p75 — technical comment. Science. 1997;277:837–838
  53. Picard N, Strick PL. Motor areas of the medial wall: a review of their location and functional activation. Cereb Cortex. 1996;6:342–353
  54. Plogmann D, Celio MR. Intracellular concentration of parvalbumin in nerve cells. Brain Res. 1993;600:273–279
  55. Rabe CS, Weight JF. Effects of ethanol on neurotransmitter release and intracellular free calcium in PC12 cells. J Pharmacol Exp Ther. 1988;244:417–422
  56. Reyes E, Wolfe J, Savage DD. The effects of prenatal ethanol exposure on radial arm maze performance in adult rats. Physiol Behav. 1989;46:45–48
  57. Rogers J, Wiener SG, Bloom FE. Long-term ethanol administration methods for rats: advantages of inhalation over intubation or liquid diets. Behav Neural Biol. 1979;27:466–486
  58. Ryabinin AE, Cole M, Bloom FE, Wilson MC. Exposure of neonatal rats to alcohol by vapor inhalation demonstrates specificity of microcephaly and Purkinje cell loss but not astrogliosis. Alcohol Clin Exp Res. 1995;19:784–791
  59. Solbach S, Celio MR. Ontogeny of the calcium binding protein parvalbumin in the rat nervous system. Anat Embryol (Berlin). 1991;184:103–124
  60. Steinhausen HC, Wilms J, Spohr HL. Long-term psychopathological and cognitive outcome of children with fetal alcohol syndrome. J Am Acad Child Adolesc Psychiatry. 1993;32:990–994
  61. Streissguth AP, Aase JM, Clarren SK, Randels SP, LaDue RA, Smith DF. Fetal alcohol syndrome in adolescents and adults. JAMA. 1991;265:1961–1967
  62. Swanson DJ, King MA, Walker DW, Heaton MB. Chronic prenatal ethanol exposure alters the normal ontogeny of choline acetyltransferase activity in the rat septohippocampal system. Alcohol Clin Exp Res. 1995;19:1252–1260
  63. Swanson DJ, Tonjes L, King MA, Walker DW, Heaton MB. The influence of chronic prenatal ethanol on cholinergic neurons of the septohippocampal system. J Comp Neurol. 1995;364:104–112

PII: S0741-8329(99)00101-9

Alcohol
Volume 21, Issue 1 , Pages 49-57 , May 2000

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